pI: 4.7813 |
Length (AA): 549 |
MW (Da): 59288 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 514 | 5dn6 (A) | 3 | 509 | 56.00 | 0 | 1 | 1.63954 | -0.7 |
20 | 511 | 2r9v (A) | 17 | 501 | 59.00 | 0 | 1 | 1.65927 | -0.96 |
27 | 511 | 1fx0 (A) | 25 | 501 | 59.00 | 0 | 1 | 1.60552 | -0.55 |
30 | 514 | 5ik2 (A) | 27 | 501 | 64.00 | 0 | 1 | 1.64782 | -0.71 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase, Dormant phase. | hasan murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_127165)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | ArthCp007 | ATP synthase CF1 alpha chain |
Arabidopsis thaliana | AT2G07698 | ATPase, F1 complex, alpha subunit protein |
Arabidopsis thaliana | ArthMp100 | ATPase subunit 1 |
Babesia bovis | BBOV_III002130 | ATP synthase F1, alpha subunit family protein |
Brugia malayi | Bm1_47570 | ATP synthase alpha chain, mitochondrial precursor, putative |
Candida albicans | CaO19.14144 | C terminus of mitochondrial F1F0 H+ATPase |
Candida albicans | CaO19.6854 | C terminus of mitochondrial F1F0 H+ATPase |
Caenorhabditis elegans | CELE_H28O16.1 | Protein H28O16.1, isoform B |
Cryptosporidium hominis | Chro.60082 | ATP synthase alpha chain |
Cryptosporidium parvum | cgd6_610 | ATP synthase alpha chain |
Dictyostelium discoideum | DidioMp11 | ATPase subunit 1 |
Drosophila melanogaster | Dmel_CG3612 | bellwether |
Escherichia coli | b3734 | F1 sector of membrane-bound ATP synthase, alpha subunit |
Echinococcus granulosus | EgrG_000720500 | ATP synthase subunit alpha mitochondrial |
Echinococcus multilocularis | EmuJ_000720500 | ATP synthase subunit alpha, mitochondrial |
Homo sapiens | ENSG00000152234 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle |
Leishmania braziliensis | LbrM.05.0520 | ATPase alpha subunit |
Leishmania donovani | LdBPK_050510.1 | ATP synthase F1, alpha subunit, putative |
Leishmania infantum | LinJ.05.0500 | ATPase alpha subunit |
Leishmania infantum | LinJ.05.0510 | ATPase alpha subunit |
Leishmania major | LmjF.05.0500 | ATPase alpha subunit |
Leishmania major | LmjF.05.0510 | ATPase alpha subunit |
Leishmania mexicana | LmxM.05.0510 | ATPase alpha subunit, putative |
Leishmania mexicana | LmxM.05.0500 | ATPase alpha subunit, putative |
Leishmania mexicana | LmxM.05.0510b | |
Mycobacterium leprae | ML1143 | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA |
Mus musculus | ENSMUSG00000025428 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 |
Mycobacterium tuberculosis | Rv1308 | Probable ATP synthase alpha chain AtpA |
Mycobacterium ulcerans | MUL_3956 | F0F1 ATP synthase subunit alpha |
Neospora caninum | NCLIV_020840 | hypothetical protein |
Oryza sativa | 3131390 | ATP synthase CF1 alpha chain |
Oryza sativa | 6450183 | ATP synthase F0 subunit 1 |
Onchocerca volvulus | OVOC1523 | ATP synthase subunit alpha, mitochondrial homolog |
Plasmodium berghei | PBANKA_0313800 | ATP synthase F1, alpha subunit, putative |
Plasmodium falciparum | PF3D7_0217100 | ATP synthase F1, alpha subunit |
Plasmodium knowlesi | PKNH_0403800 | ATP synthase F1, alpha subunit, putative |
Plasmodium vivax | PVX_002685 | ATP synthase alpha chain, putative |
Plasmodium yoelii | PY05971 | ATP synthase F1, alpha subunit |
Saccharomyces cerevisiae | YBL099W | F1F0 ATP synthase subunit alpha |
Schistosoma japonicum | Sjp_0089940 | ko:K02132 F-type H+-transporting ATPase alpha chain, putative |
Schistosoma mansoni | Smp_002880.2 | ATP synthase alpha subunit mitochondrial |
Schmidtea mediterranea | mk4.000367.04 | |
Schmidtea mediterranea | mk4.010027.01 | ATP synthase subunit alpha, mitochondrial |
Schmidtea mediterranea | mk4.000367.03 | ATP synthase subunit alpha, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.7.8720 | ATP synthase alpha chain, mitochondrial precursor, putative |
Trypanosoma brucei | Tb927.7.7430 | ATP synthase F1, alpha subunit |
Trypanosoma brucei | Tb927.7.7420 | ATP synthase F1, alpha subunit |
Trypanosoma congolense | TcIL3000_7_6050 | ATP synthase F1, alpha subunit, putative |
Theileria parva | TP03_0569 | ATP synthase F1, alpha chain, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0314 | ATP synthase F0F1 subunit alpha |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1330 this record | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.7.7420 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.7420 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.7420 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.7420 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3734 | Escherichia coli | non-essential | goodall |
CELE_H28O16.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_H28O16.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_H28O16.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_H28O16.1 | Caenorhabditis elegans | sterile | wormbase |
CELE_H28O16.1 | Caenorhabditis elegans | terminal arrest variable | wormbase |
PBANKA_0313800 | Plasmodium berghei | Slow | plasmo |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.7
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Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 486 aa | 24.5% | 416 aa | Compounds | References |
Target | Type | Source | Notes |
---|---|---|---|
Rv1308 | purified protein | BRENDA | A protein with this EC number or name or sequence has been purified from Mycobacterium phlei ( 1 ) |
15 literature references were collected for this gene.