pI: 6.5025 |
Length (AA): 529 |
MW (Da): 56746 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 529 | 4q0g (A) | 11 | 529 | 99.99 | 0 | 1 | 2.1709 | -0.99 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129211)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G34030 | methylcrotonoyl-CoA carboxylase beta chain |
Caenorhabditis elegans | CELE_F02A9.4 | Protein F02A9.4, isoform A |
Dictyostelium discoideum | DDB_G0271960 | 3-methylcrotonyl-CoA:carbon dioxide ligase beta subunit |
Drosophila melanogaster | Dmel_CG3267 | CG3267 gene product from transcript CG3267-RA |
Homo sapiens | ENSG00000131844 | methylcrotonoyl-CoA carboxylase 2 (beta) |
Leishmania braziliensis | LbrM.11.0370 | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative |
Leishmania donovani | LdBPK_110600.1 | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative |
Leishmania infantum | LinJ.11.0600 | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative |
Leishmania major | LmjF.11.0590 | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative |
Leishmania mexicana | LmxM.11.0590 | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative |
Mus musculus | ENSMUSG00000021646 | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) |
Mycobacterium tuberculosis | Rv2502c | Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1 |
Neospora caninum | NCLIV_036840 | acyl-CoA carboxyltransferase beta chain, putative |
Oryza sativa | 4345605 | Os08g0424200 |
Schmidtea mediterranea | mk4.088796.01 | |
Schmidtea mediterranea | mk4.041435.00 | Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial |
Schmidtea mediterranea | mk4.002162.05 | Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.11.7500 | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative |
Trypanosoma brucei | Tb927.11.6630 | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative |
Trypanosoma congolense | TcIL3000_0_44270 | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative |
Trypanosoma cruzi | TcCLB.508799.170 | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative |
Trypanosoma cruzi | TcCLB.506773.40 | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative |
Toxoplasma gondii | TGME49_269680 | acyl-CoA carboxyltransferase beta chain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.4480 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.4480 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.4480 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.4480 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F02A9.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F02A9.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F02A9.4 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_269680 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.