Detailed view for Rv2882c

Basic information

TDR Targets ID: 6096
Mycobacterium tuberculosis, Ribosome recycling factor Frr (ribosome releasing factor) (RRF)
Source Database / ID:  Tuberculist 

pI: 5.7655 | Length (AA): 185 | MW (Da): 20828 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01765   Ribosome recycling factor

Gene Ontology

Mouse over links to read term descriptions.
GO:0006412   translation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 184 4kdd (A) 1 184 99.99 0 1 2.26399 -1.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1WQF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1WQG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 1WQH:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4KAW:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4KB2:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4KB4:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4KC6:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4KDD:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase. murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_127647)

Species Accession Gene Product
Arabidopsis thaliana AT3G01800   ribosome recycling factor
Arabidopsis thaliana AT3G63190   ribosome-recycling factor
Brugia malayi Bm1_29280   ribosome recycling factor family protein
Candida albicans CaO19.477   similar to S. cerevisiae RRF1 (YHR038W) mitochondrial translation termination and ribosome recycling factor
Candida albicans CaO19.8108   similar to S. cerevisiae RRF1 (YHR038W) mitochondrial translation termination and ribosome recycling factor
Caenorhabditis elegans CELE_T20F5.3   Protein MRRF-1
Chlamydia trachomatis CT_677   ribosome-recycling factor
Dictyostelium discoideum DDB_G0268518   hypothetical protein
Drosophila melanogaster Dmel_CG4447   CG4447 gene product from transcript CG4447-RA
Escherichia coli b0172   ribosome recycling factor
Homo sapiens ENSG00000148187   mitochondrial ribosome recycling factor
Loa Loa (eye worm) LOAG_05261   ribosome recycling factor family protein
Mycobacterium leprae ML1590c   RIBOSOME RECYCLING FACTOR FRR (RIBOSOME RELEASING FACTOR) (RRF)
Mus musculus ENSMUSG00000026887   mitochondrial ribosome recycling factor
Mycobacterium tuberculosis Rv2882c   Ribosome recycling factor Frr (ribosome releasing factor) (RRF)
Mycobacterium ulcerans MUL_2075   ribosome recycling factor
Neospora caninum NCLIV_028380   hypothetical protein, conserved
Oryza sativa 4336241   Os04g0490400
Oryza sativa 4343662   Os07g0570700
Saccharomyces cerevisiae YHR038W   Rrf1p
Toxoplasma gondii TGME49_257980   ribosome recycling factor protein
Treponema pallidum TP0604   ribosome recycling factor
Wolbachia endosymbiont of Brugia malayi Wbm0805   ribosome recycling factor

Essentiality

Rv2882c has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu2929 this record Mycobacterium tuberculosis essential nmpdr
b0172 Escherichia coli essential goodall
TGME49_257980 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2882c (Mycobacterium tuberculosis), Ribosome recycling factor Frr (ribosome releasing factor) (RRF)
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