Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0075 | 0.0403 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0214 | 0.2446 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0588 | 0.7957 | 0.8948 |
Brugia malayi | Pre-SET motif family protein | 0.0211 | 0.2404 | 0.2404 |
Toxoplasma gondii | aminopeptidase N protein | 0.0075 | 0.0403 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0403 | 0.0453 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0214 | 0.2446 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0214 | 0.2446 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0214 | 0.2446 | 1 |
Onchocerca volvulus | 0.0727 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0403 | 0.0453 |
Echinococcus multilocularis | aminopeptidase N | 0.0727 | 1 | 1 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0075 | 0.0403 | 0.5 |
Onchocerca volvulus | 0.024 | 0.2833 | 0.2532 | |
Brugia malayi | Peptidase family M1 containing protein | 0.0075 | 0.0403 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0652 | 0.8892 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0214 | 0.2446 | 0.8407 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0214 | 0.2446 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0075 | 0.0403 | 0.0403 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0214 | 0.2446 | 0.8407 |
Brugia malayi | hypothetical protein | 0.0214 | 0.2446 | 0.2446 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0075 | 0.0403 | 0.1647 |
Loa Loa (eye worm) | aminopeptidase N | 0.0214 | 0.2446 | 0.2751 |
Trichomonas vaginalis | set domain proteins, putative | 0.024 | 0.2833 | 1 |
Onchocerca volvulus | 0.0214 | 0.2446 | 0.2129 | |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0075 | 0.0403 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0214 | 0.2446 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0075 | 0.0403 | 0.0403 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0075 | 0.0403 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0214 | 0.2446 | 0.2446 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0139 | 0.1338 | 0.1338 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0075 | 0.0403 | 0.0403 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0214 | 0.2446 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0214 | 0.2446 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0214 | 0.2446 | 0.2446 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0075 | 0.0403 | 0.1647 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0075 | 0.0403 | 0.1647 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0214 | 0.2446 | 0.2446 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0214 | 0.2446 | 0.2446 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0214 | 0.2446 | 0.2446 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0075 | 0.0403 | 0.0403 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0075 | 0.0403 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0211 | 0.2404 | 0.2703 |
Echinococcus granulosus | aminopeptidase N | 0.0727 | 1 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0075 | 0.0403 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1338 | 0.1505 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0214 | 0.2446 | 0.2446 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0214 | 0.2446 | 0.2446 |
Brugia malayi | Peptidase family M1 containing protein | 0.0214 | 0.2446 | 0.2446 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0139 | 0.1338 | 0.4578 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.6849 | 0.7702 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0214 | 0.2446 | 0.2446 |
Brugia malayi | TATA binding protein associated factor | 0.0075 | 0.0403 | 0.0403 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0075 | 0.0403 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1338 | 0.1505 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0403 | 0.0403 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0214 | 0.2446 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0214 | 0.2446 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0214 | 0.2446 | 0.2446 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0214 | 0.2446 | 0.2446 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0403 | 0.0453 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0214 | 0.2446 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0214 | 0.2446 | 1 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0139 | 0.1338 | 0.5471 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0075 | 0.0403 | 0.0453 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 1.67 umol/min/mg | Activity at human recombinant PON1 assessed as hydrolysis of lactone ring at 1 mM by Ellman's method | ChEMBL. | 18572410 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.