Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melatonin receptor 1B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | melatonin receptor 1B | 362 aa | 329 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0209 | 0.0381 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0209 | 0.0381 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 1 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.5496 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.002 | 0.5496 | 0.4306 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.002 | 0.5496 | 0.4306 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.972 | 0.9714 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0209 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0209 | 0.0000000045414 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.5496 | 0.5 |
Entamoeba histolytica | recQ family helicase, putative | 0.002 | 0.5496 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.002 | 0.5496 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.002 | 0.5496 | 0.4306 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.2902 | 0.2751 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.5496 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1811 | 0.1636 |
Echinococcus granulosus | lamin | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.002 | 0.5496 | 0.54 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.5496 | 0.5 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.5496 | 0.3655 |
Brugia malayi | Bloom's syndrome protein homolog | 0.002 | 0.5496 | 0.3655 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.002 | 0.5496 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0209 | 1 |
Echinococcus multilocularis | lamin | 0.0028 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.002 | 0.5496 | 0.54 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.5496 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.002 | 0.5496 | 0.4306 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.002 | 0.5496 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 1 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.5496 | 0.3655 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.5496 | 0.5 |
Schistosoma mansoni | DNA helicase recq5 | 0.002 | 0.5496 | 0.5496 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.209 | 0.1921 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.002 | 0.5496 | 0.5496 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.002 | 0.5496 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1811 | 0.1636 |
Echinococcus granulosus | bloom syndrome protein | 0.002 | 0.5496 | 0.4306 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0209 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.5496 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.5496 | 0.54 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 1 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.002 | 0.5496 | 0.4306 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as radiolabelled ligand | ChEMBL. | 9207940 |
IC50 (binding) | > 10000 nM | Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as radiolabelled ligand | ChEMBL. | 9207940 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.