Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Phenylethanolamine N-methyltransferase | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0333 | 0.3963 | 0.106 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0333 | 0.3963 | 0.106 |
Loa Loa (eye worm) | glutaminase | 0.0328 | 0.38 | 0.0818 |
Loa Loa (eye worm) | hypothetical protein | 0.0531 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0214 | 0.0334 | 0.0878 |
Loa Loa (eye worm) | glutaminase 2 | 0.0328 | 0.38 | 0.0818 |
Schistosoma mansoni | glutaminase | 0.0328 | 0.38 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.031 | 0.3247 | 0.8546 |
Mycobacterium ulcerans | glutaminase | 0.0328 | 0.38 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.031 | 0.3247 | 0.8546 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.031 | 0.3247 | 0.8546 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.3963 | 0.106 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.031 | 0.3247 | 0.8546 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.3963 | 0.106 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.031 | 0.3247 | 0.8546 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.031 | 0.3247 | 0.8546 |
Echinococcus multilocularis | geminin | 0.0203 | 0.0000077991 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0328 | 0.38 | 0.0818 |
Onchocerca volvulus | 0.0531 | 1 | 1 | |
Trichomonas vaginalis | glutaminase, putative | 0.0328 | 0.38 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0214 | 0.0334 | 0.0878 |
Echinococcus granulosus | geminin | 0.0203 | 0.0000077991 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0531 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6 | Inhibitory activity against bovine adrenal phenylethanolamine N-methyltransferase (PNMT) | ChEMBL. | 10091706 |
Ki (binding) | = 6.31 | Inhibition of [3H]-clonidine binding to the rat alpha2-adrenoceptor | ChEMBL. | 10091706 |
Ki (binding) | = 0.49 uM | In vitro binding affinity towards cortical membranes of male Sprague-Dawley rats alpha-2 adrenergic receptor by replacing [3H]-Clonidine | ChEMBL. | 10354406 |
Ki (binding) | = 0.49 uM | In vitro binding affinity towards cortical membranes of male Sprague-Dawley rats alpha-2 adrenergic receptor by replacing [3H]-Clonidine | ChEMBL. | 10354406 |
Ki (binding) | = 0.52 uM | In vitro for binding affinity against Alpha-2 adrenergic receptor by radioligand [3H]-Clonidine in rat | ChEMBL. | 8784452 |
Ki (binding) | = 0.52 uM | In vitro for binding affinity against Alpha-2 adrenergic receptor by radioligand [3H]-Clonidine in rat | ChEMBL. | 8784452 |
Ki (binding) | = 1 uM | In vitro inhibitory activity against bovine adrenal phenylethanolamine N-methyl transferase | ChEMBL. | 10354406 |
Ki (binding) | = 1 uM | In vitro inhibitory activity against bovine adrenal phenylethanolamine N-methyl transferase | ChEMBL. | 10354406 |
Ki (binding) | = 1.01 uM | In vitro for inhibition of Phenylethanolamine N-Methyltransferase (PNMT) | ChEMBL. | 8784452 |
Ki (binding) | = 1.01 uM | In vitro for inhibition of Phenylethanolamine N-Methyltransferase (PNMT) | ChEMBL. | 8784452 |
Ki (binding) | = 5.7 uM | In vitro inhibition of [3H]-clonidine binding at the alpha-2 adrenergic receptor. | ChEMBL. | 10543879 |
Ki (binding) | = 5.7 uM | In vitro inhibition of [3H]-clonidine binding at the alpha-2 adrenergic receptor. | ChEMBL. | 10543879 |
Ki (binding) | = 38 uM | In vitro inhibition of PNMT (Phenylethanolamine N-Methyltransferase). | ChEMBL. | 10543879 |
Ki (binding) | = 38 uM | In vitro inhibition of PNMT (Phenylethanolamine N-Methyltransferase). | ChEMBL. | 10543879 |
Log Ki (binding) | = 6 | Inhibitory activity against bovine adrenal phenylethanolamine N-methyltransferase (PNMT) | ChEMBL. | 10091706 |
Log Ki (binding) | = 6.31 | Inhibition of [3H]-clonidine binding to the rat alpha2-adrenoceptor | ChEMBL. | 10091706 |
Ratio (binding) | = 0.51 | Seletivity ratio between Ki of alpha-2 adrenoceptor and Ki of PNMT | ChEMBL. | 8784452 |
Selectivity (binding) | = 0.15 | Ratio of binding affinity of PNMT to alpha-2 receptors. | ChEMBL. | 10543879 |
Selectivity (binding) | = 0.49 | Selectivity ratio between PNMT and alpha2 receptors | ChEMBL. | 10354406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.