Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RecQ helicase | 0.0019 | 0.3222 | 0.4631 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0019 | 0.3222 | 1 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0124 | 0.0385 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0124 | 0.0385 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0019 | 0.3222 | 0.3137 |
Echinococcus granulosus | dna polymerase eta | 0.0014 | 0.1517 | 0.1411 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0124 | 0.0385 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0124 | 0.0385 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.3222 | 0.8102 |
Schistosoma mansoni | DNA helicase recq5 | 0.0019 | 0.3222 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0124 | 0.0002 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0014 | 0.1517 | 0.2082 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.29 | 0.8998 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.29 | 0.6567 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0019 | 0.3222 | 0.3137 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0019 | 0.3222 | 0.0455 |
Echinococcus multilocularis | dna polymerase kappa | 0.004 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0014 | 0.1517 | 0.1412 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.2189 | 0.2122 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0123 | 0.0381 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0124 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0124 | 0.0002 |
Onchocerca volvulus | 0.001 | 0.0124 | 0.5 | |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0014 | 0.1517 | 0.4709 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0124 | 0.0385 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0124 | 0.0385 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0124 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0124 | 0.0002 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0124 | 0.0385 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0014 | 0.1517 | 0.1411 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.29 | 0.2811 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.29 | 0.6567 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0019 | 0.3222 | 0.447 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0124 | 0.0385 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0123 | 0.0381 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0124 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 0.6816 | 0.6789 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.2189 | 0.2122 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0014 | 0.1517 | 0.1445 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0124 | 0.5 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0019 | 0.3222 | 0.4631 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0019 | 0.3222 | 0.0455 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0124 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0124 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0124 | 0.0002 |
Brugia malayi | polk-prov protein | 0.003 | 0.6816 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0019 | 0.3222 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.3222 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.29 | 0.4148 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.29 | 0.4149 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0124 | 0.0002 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0014 | 0.1517 | 0.2084 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0019 | 0.3222 | 0.3137 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.3622 | 0.3568 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.3222 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.6816 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0124 | 0.0002 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0123 | 0.0381 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0124 | 0.0385 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0124 | 0.0385 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.29 | 0.8998 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0123 | 0.0000000038949 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.004 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.004 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0014 | 0.1517 | 0.4709 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0011 | 0.0438 | 0.1359 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.29 | 0.8998 |
Mycobacterium ulcerans | DNA polymerase IV | 0.004 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.29 | 0.281 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0014 | 0.1517 | 0.1411 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0124 | 0.0002 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.29 | 0.2839 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0124 | 0.0385 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0033 | 0.7895 | 0.7878 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0124 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0124 | 0.0002 |
Trypanosoma brucei | unspecified product | 0.0033 | 0.7895 | 0.7878 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0019 | 0.3222 | 0.3137 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.003 | 0.6816 | 0.6789 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.3622 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.29 | 0.281 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0124 | 0.0385 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.1517 | 0.2084 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0019 | 0.3222 | 0.0455 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0124 | 0.0002 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.3222 | 0.463 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.3222 | 0.3138 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0019 | 0.3222 | 0.3165 |
Echinococcus granulosus | bloom syndrome protein | 0.0019 | 0.3222 | 0.3137 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0124 | 0.0385 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0124 | 0.0002 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.29 | 0.2811 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0124 | 0.0002 |
Echinococcus multilocularis | bloom syndrome protein | 0.0019 | 0.3222 | 0.3137 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.29 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0014 | 0.1517 | 0.4709 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.3622 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0014 | 0.1517 | 0.2082 |
Mycobacterium ulcerans | DNA polymerase IV | 0.004 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0014 | 0.1517 | 0.1411 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.29 | 0.8998 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.29 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0019 | 0.3222 | 0.463 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0019 | 0.3222 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0014 | 0.1517 | 0.4709 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 1 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0123 | 0.0423 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.3622 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.3622 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0019 | 0.3222 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.29 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.3222 | 0.4631 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0124 | 0.0002 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.2189 | 0.2122 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.3222 | 0.463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.