Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0133 | 0.0138 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.3274 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0133 | 0.0138 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0133 | 0.0138 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0133 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0133 | 0.0133 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0133 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0133 | 0.0138 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0133 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0133 | 0.0133 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.3274 | 0.3432 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0133 | 0.0133 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0133 | 0.0133 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0133 | 0.0138 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0133 | 0.0133 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0133 | 0.0133 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0133 | 0.0138 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0133 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0133 | 0.0138 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0133 | 0.0138 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0466 | 0.0482 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0133 | 0.0133 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0133 | 0.0138 |
Echinococcus granulosus | long chain fatty acid transport protein 4 | 0.0183 | 0.9672 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0466 | 0.0482 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0466 | 0.0466 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0133 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0466 | 0.0482 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.2466 | 0.2466 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0133 | 0.0138 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.3274 | 0.3274 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0189 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2466 | 0.2466 |
Schistosoma mansoni | FFA transport protein | 0.0183 | 0.9672 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0133 | 0.0133 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0189 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0133 | 0.0133 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0133 | 0.0138 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0183 | 0.9672 | 1 |
Leishmania major | fatty acid transporter protein-like protein | 0.0181 | 0.954 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0133 | 0.0138 |
Trypanosoma cruzi | fatty acid transporter protein-like, putative | 0.0183 | 0.9672 | 1 |
Echinococcus multilocularis | long chain fatty acid transport protein 4 | 0.0183 | 0.9672 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0133 | 0.0138 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0181 | 0.954 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0133 | 0.0138 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.3274 | 0.3385 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0133 | 0.0138 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0466 | 0.0466 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0133 | 0.0138 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0133 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.154 | 0.1593 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0133 | 0.0133 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0133 | 0.0138 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.3274 | 0.3432 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0133 | 0.0133 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0133 | 0.0133 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0008 | 0 | 0.5 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.154 | 0.154 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0133 | 0.0133 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.3274 | 0.3274 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0133 | 0.0133 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0133 | 0.0138 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.3274 | 0.3385 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.2466 | 0.2466 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0133 | 0.0133 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0133 | 0.0138 |
Mycobacterium leprae | possible long-chain acyl-CoA synthase | 0.0181 | 0.954 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0133 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0466 | 0.0482 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0133 | 0.0133 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.3274 | 0.3274 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0466 | 0.0466 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0466 | 0.0482 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0466 | 0.0482 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0133 | 0.0133 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0133 | 0.0138 |
Onchocerca volvulus | 0.0011 | 0.0133 | 1 | |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0466 | 0.0482 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0133 | 0.0138 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0133 | 0.0138 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0133 | 0.0133 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0133 | 0.0138 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0133 | 0.0133 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0133 | 0.0133 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.154 | 0.154 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0133 | 0.0133 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0466 | 0.0482 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0133 | 0.0133 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.2466 | 0.2466 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0133 | 0.0133 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.3274 | 0.3385 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0133 | 0.0133 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0133 | 0.0133 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0133 | 0.0138 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0466 | 0.0482 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0133 | 0.0138 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0133 | 0.0133 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0133 | 0.0138 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0133 | 0.0133 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0133 | 0.0133 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0133 | 0.0138 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0133 | 0.0138 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0133 | 0.0133 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0133 | 0.0138 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0133 | 0.0133 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0133 | 0.0133 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0133 | 0.0133 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0466 | 0.0466 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.3274 | 0.3385 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0133 | 0.0133 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0133 | 0.0138 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0466 | 0.0482 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 26 % | Growth inhibition of mouse P388 cells at 0.1 ug/mL after 48 hrs relative to control | ChEMBL. | 1479379 |
GI (functional) | = 65 % | Growth inhibition of mouse P388 cells at 1 ug/mL after 48 hrs relative to control | ChEMBL. | 1479379 |
GI (functional) | = 103 % | Growth inhibition of mouse P388 cells at 10 ug/mL after 48 hrs relative to control | ChEMBL. | 1479379 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.