Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | furin (paired basic amino acid cleaving enzyme) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0111 | 0.1799 | 0.1765 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0042 | 0.0177 | 0.0412 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0041 | 0.024 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0041 | 0.5 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0042 | 0.0177 | 0.053 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.0618 | 0.058 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0177 | 0.3335 | 1 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0108 | 0.1713 | 0.1679 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0618 | 0.1854 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0041 | 0.0123 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0041 | 0.024 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0111 | 0.1799 | 0.1765 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.0618 | 0.1274 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.0618 | 1 |
Echinococcus multilocularis | 0.0143 | 0.2535 | 0.2504 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0041 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0041 | 0.024 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0108 | 0.1713 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0042 | 0.0177 | 0.1032 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0077 | 0.0999 | 0.2995 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0041 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.0618 | 0.058 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0618 | 0.1854 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0042 | 0.0177 | 0.1032 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0462 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0041 | 0.024 |
Onchocerca volvulus | 0.0036 | 0.0041 | 0.5 | |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0042 | 0.0177 | 0.1032 |
Onchocerca volvulus | 0.0036 | 0.0041 | 0.5 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0618 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0822 | 0.2371 |
Giardia lamblia | High cysteine membrane protein Group 2 | 0.0066 | 0.0737 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0042 | 0.0177 | 0.1032 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0462 | 1 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0042 | 0.0177 | 0.1032 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0618 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0041 | 0.0123 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0042 | 0.0177 | 0.1032 |
Echinococcus granulosus | furin | 0.0177 | 0.3335 | 0.3307 |
Onchocerca volvulus | 0.0036 | 0.0041 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0041 | 0.5 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0108 | 0.1713 | 0.1679 |
Echinococcus multilocularis | Furin 1 | 0.0042 | 0.0177 | 0.0136 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0618 | 1 |
Brugia malayi | celfurPC protein | 0.0143 | 0.2535 | 0.7572 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0041 | 0.024 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0041 | 0.5 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.0111 | 0.1799 | 0.5335 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3335 | 1 |
Brugia malayi | proprotein convertase 2 | 0.0111 | 0.1799 | 0.5335 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0041 | 0.5 |
Echinococcus granulosus | Furin 1 | 0.0042 | 0.0177 | 0.0136 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.0618 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0108 | 0.1713 | 1 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0177 | 0.3335 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.023 | 0.4572 | 1 |
Brugia malayi | endoprotease bli-4 precursor | 0.0177 | 0.3335 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0041 | 0.024 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0462 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 0.1 uM | Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage | ChEMBL. | 17537721 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.