Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.328 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0018 | 0.0383 | 0.0383 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.024 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0.0383 | 0.2968 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.024 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.024 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.129 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.024 | 1 | 1 |
Onchocerca volvulus | 0.024 | 1 | 1 | |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.328 | 0.328 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.0383 | 0.0383 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.2601 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.129 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0069 | 0.2601 | 1 |
Onchocerca volvulus | 0.0018 | 0.0383 | 0.0264 | |
Echinococcus granulosus | cathepsin l1 | 0.0018 | 0.0383 | 0.0383 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.129 | 0.129 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.2601 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.024 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Onchocerca volvulus | 0.0018 | 0.0383 | 0.0264 | |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.328 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0012 | 0.0122 | 0.0944 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0143 | 0.578 | 0.578 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.328 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0063 | 0.234 | 0.8997 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Onchocerca volvulus | 0.0018 | 0.0383 | 0.0264 | |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.328 | 0.328 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0018 | 0.0383 | 0.0264 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0056 | 0.201 | 0.201 |
Brugia malayi | Probable ClpP-like protease | 0.0085 | 0.328 | 0.328 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.129 | 0.129 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.129 | 0.129 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.129 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0.0864 | 0.1659 |
Brugia malayi | cathepsin L-like precursor | 0.0012 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.024 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0029 | 0.0864 | 0.2633 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.2601 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0085 | 0.328 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.328 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0012 | 0.0122 | 0.0122 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.129 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.024 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.328 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0018 | 0.0383 | 0.0264 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0085 | 0.328 | 0.328 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0029 | 0.0864 | 0.2633 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0018 | 0.0383 | 0.1167 |
Onchocerca volvulus | 0.0018 | 0.0383 | 0.0264 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.2601 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.328 | 0.3197 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0383 | 0.0383 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0018 | 0.0383 | 0.0383 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.0383 | 0.0383 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0018 | 0.0383 | 0.0383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0018 | 0.0383 | 0.0264 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0018 | 0.0383 | 0.1167 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.328 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0383 | 0.0383 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0056 | 0.201 | 0.201 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0085 | 0.328 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0018 | 0.0383 | 0.0264 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0055 | 0.1957 | 0.7525 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0383 | 0.0383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0122 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0383 | 0.0264 |
Echinococcus granulosus | cathepsin l1 | 0.0012 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0018 | 0.0383 | 0.0264 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0018 | 0.0383 | 0.2968 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.0383 | 0.0383 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0012 | 0.0122 | 0.0122 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0056 | 0.201 | 0.4744 |
Onchocerca volvulus | 0.0018 | 0.0383 | 0.0264 | |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.2601 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0018 | 0.0383 | 0.0264 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0122 | 0.0122 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0018 | 0.0383 | 0.0383 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0056 | 0.201 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.328 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0.0383 | 0.1167 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0018 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.2601 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0018 | 0.0383 | 0.0264 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.5222 | 0.5163 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0383 | 0.0383 |
Onchocerca volvulus | 0.0018 | 0.0383 | 0.0264 | |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0056 | 0.201 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.0383 | 0.0383 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.328 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0012 | 0.0122 | 0.3182 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0018 | 0.0383 | 0.1167 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.5222 | 0.5222 |
Entamoeba histolytica | cysteine protease, putative | 0.0018 | 0.0383 | 0.2968 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0383 | 0.0383 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.129 | 0.129 |
Onchocerca volvulus | Cathepsin F homolog | 0.0018 | 0.0383 | 0.0264 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0018 | 0.0383 | 0.1472 |
Brugia malayi | Cathepsin L-like precursor | 0.0012 | 0.0122 | 0.0122 |
Brugia malayi | hypothetical protein | 0.0039 | 0.129 | 0.129 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0018 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.5222 | 0.5163 |
Onchocerca volvulus | 0.0018 | 0.0383 | 0.0264 | |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0097 | 0.3813 | 0.3813 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0018 | 0.0383 | 0.0383 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.328 | 1 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0.0383 | 0.1167 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0018 | 0.0383 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.2601 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0018 | 0.0383 | 0.0383 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.