Detailed information for compound 1015828

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.563 | Formula: C24H31FO6S
  • H donors: 3 H acceptors: 4 LogP: 3.06 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCOCc1sc(c(c1c1ccc(cc1)F)/C=C/[C@H](C[C@H](CC(=O)O)O)O)C(C)C
  • InChi: 1S/C24H31FO6S/c1-15(2)24-20(9-8-18(26)12-19(27)13-22(28)29)23(16-4-6-17(25)7-5-16)21(32-24)14-31-11-10-30-3/h4-9,15,18-19,26-27H,10-14H2,1-3H3,(H,28,29)/b9-8+/t18-,19-/m1/s1
  • InChiKey: RPTBVDQITSDSED-TYFAACHXSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0061 0.1534 0.1772
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0131 0.0151
Trypanosoma brucei glucose transporter, putative 0.0027 0.0585 0.2302
Echinococcus granulosus General substrate transporter 0.0074 0.1899 0.2192
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.1821 0.2103
Brugia malayi transcription factor E74 isoform 0.001 0.0131 0.0223
Brugia malayi Sugar transporter family protein 0.0012 0.018 0.0308
Leishmania major glucose transporter, lmgt3 0.0027 0.0585 0.2302
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Plasmodium falciparum protein kinase 7 0.0243 0.6608 0.6608
Schistosoma mansoni protein kinase 0.0027 0.0585 0.0675
Schistosoma mansoni lysyl-tRNA synthetase 0.0019 0.0377 0.0436
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0452 0.0521
Trypanosoma brucei glucose transporter, putative 0.0027 0.0585 0.2302
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0131 0.0151
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0012 0.018 0.0208
Echinococcus granulosus snurportin 1 0.0317 0.866 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1116 0.1289
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0017 0.0312 0.1226
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0585 0.0675
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0012 0.018 0.2954
Echinococcus multilocularis solute carrier family 22 0.0012 0.018 0.0208
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0027 0.0585 0.0585
Trichomonas vaginalis glucose transporter, putative 0.0012 0.018 0.0708
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0131 0.0151
Echinococcus granulosus solute carrier family 22 0.0012 0.018 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1116 0.1289
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1116 0.1289
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Echinococcus granulosus importin subunit beta 1 0.003 0.067 0.0773
Schistosoma mansoni lysyl-tRNA synthetase 0.0019 0.0377 0.0436
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0027 0.0585 0.2299
Schistosoma mansoni protein kinase 0.0027 0.0585 0.0675
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0012 0.018 0.0208
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.2543 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0027 0.0585 0.0585
Trypanosoma brucei glucose transporter, putative 0.0027 0.0585 0.2302
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.2543 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0585 0.2302
Entamoeba histolytica protein kinase, putative 0.0027 0.0585 0.2299
Plasmodium vivax sugar transporter, putative 0.0012 0.018 0.018
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0012 0.018 0.5
Schistosoma mansoni importin beta-1 0.003 0.067 0.0773
Brugia malayi Importin beta-1 subunit 0.003 0.067 0.1145
Entamoeba histolytica Ran family GTPase 0.0022 0.0452 0.1776
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Schistosoma mansoni protein kinase 0.0027 0.0585 0.0675
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0027 0.0585 0.0675
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.2543 0.2936
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1116 0.1289
Plasmodium falciparum calcium-dependent protein kinase 3 0.0027 0.0585 0.0585
Trichomonas vaginalis glucose transporter, putative 0.0027 0.0585 0.2302
Loa Loa (eye worm) hypothetical protein 0.0026 0.0561 0.0648
Toxoplasma gondii facilitative glucose transporter GT1 0.0086 0.2235 0.3382
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0086 0.2235 0.258
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0026 0.0561 0.2206
Plasmodium vivax CDK-related protein kinase 6, putative 0.0365 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.018 0.0708
Schistosoma mansoni ets-related 0.001 0.0131 0.0151
Echinococcus granulosus solute carrier family 22 0.0012 0.018 0.0208
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0513 0.2019
Leishmania major protein kinase, putative 0.0027 0.0585 0.2299
Trypanosoma brucei sugar transporter, putative 0.0012 0.018 0.0708
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Toxoplasma gondii transporter, major facilitator family protein 0.0012 0.018 0.0272
Plasmodium falciparum lysine--tRNA ligase 0.0019 0.0377 0.0377
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.2543 1
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0131 0.0151
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0139 0.3716 0.3716
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.2543 0.2936
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0585 0.0675
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.067 0.1013
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Schistosoma mansoni sugar transporter 0.0012 0.018 0.0208
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0452 0.0521
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0026 0.0561 0.0648
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.2543 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2543 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0027 0.0585 0.0585
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.018 0.0308
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Entamoeba histolytica protein kinase, putative 0.0027 0.0585 0.2299
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0026 0.0561 0.0648
Echinococcus multilocularis lysyl tRNA synthetase 0.0019 0.0377 0.0436
Brugia malayi Sugar transporter family protein 0.0086 0.2235 0.3822
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0026 0.0561 0.096
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.067 0.2633
Toxoplasma gondii protein kinase, putative 0.0243 0.6608 1
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.1203 0.4731
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Trypanosoma brucei glucose transporter, putative 0.0027 0.0585 0.2302
Mycobacterium ulcerans integral membrane transport protein 0.0012 0.018 0.2954
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0026 0.0561 0.2206
Schistosoma mansoni elf1 0.001 0.0131 0.0151
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0012 0.018 0.2954
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Echinococcus multilocularis synaptic vesicle 2 protein 0.0012 0.018 0.0208
Toxoplasma gondii sugar transporter ST1 0.0012 0.018 0.0272
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0086 0.2235 0.258
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0054 0.0214
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.2543 0.2936
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0086 0.2235 0.258
Brugia malayi Fli-1 protein 0.0216 0.5847 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0027 0.0585 0.2302
Loa Loa (eye worm) hypothetical protein 0.003 0.067 0.0773
Echinococcus multilocularis protein C ets 2 0.001 0.0131 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0131 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0513 0.2019
Echinococcus granulosus lysyl tRNA synthetase 0.0019 0.0377 0.0436
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.2543 0.4349
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Brugia malayi lysyl-tRNA synthetase 0.0019 0.0377 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.018 0.0708
Toxoplasma gondii sugar transporter ST3 0.0012 0.018 0.0272
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Trichomonas vaginalis sugar transporter, putative 0.0027 0.0585 0.2302
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.018 0.0708
Plasmodium falciparum hexose transporter 0.0086 0.2235 0.2235
Loa Loa (eye worm) hypothetical protein 0.0027 0.0585 0.0675
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0019 0.0377 1
Trichomonas vaginalis CAMK family protein kinase 0.0027 0.0585 0.2299
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.018 0.0708
Echinococcus multilocularis snurportin 1 0.0317 0.866 1
Echinococcus granulosus solute carrier family 22 0.0012 0.018 0.0208
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0086 0.2235 0.258
Plasmodium vivax importin-beta 2, putative 0.003 0.067 0.067
Chlamydia trachomatis lysine--tRNA ligase 0.0019 0.0377 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0427 0.0493
Trypanosoma brucei glucose transporter, putative 0.0027 0.0585 0.2302
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0131 0.0151
Leishmania major glucose transporter, lmgt1 0.0027 0.0585 0.2302
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0019 0.0377 0.1484
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Trypanosoma brucei glucose transporter 2A 0.0027 0.0585 0.2302
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.003 0.068 0.2674
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0452 0.0452
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0131 0.0151
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0026 0.0561 1
Loa Loa (eye worm) fli-1 protein 0.0216 0.5847 0.6751
Trypanosoma brucei glucose transporter 1E 0.0027 0.0585 0.2302
Plasmodium falciparum mitogen-activated protein kinase 2 0.0139 0.3716 0.3716
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0027 0.0585 0.0675
Schistosoma mansoni ets 0.001 0.0131 0.0151
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0131 0.0151
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0027 0.0585 0.0885
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0027 0.0585 0.0675
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.018 0.0308
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0585 0.0675
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0452 0.1776
Trypanosoma brucei THT1 - hexose transporter, putative 0.0027 0.0585 0.2302
Trichomonas vaginalis sugar transporter, putative 0.0027 0.0585 0.2302
Toxoplasma gondii sugar transporter ST2 0.0012 0.018 0.0272
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0452 0.0772
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0139 0.3716 0.5624
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.003 0.068 0.1029
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Brugia malayi RNA, U transporter 1 0.0084 0.2192 0.375
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.2543 0.2936
Echinococcus granulosus Sugar transporter ERD6 protein 0.0012 0.018 0.0208
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.866 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2543 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0019 0.0377 0.0836
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.1821 0.2103
Leishmania major lysyl-tRNA synthetase, putative 0.0019 0.0377 0.1484
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0452 0.0683
Echinococcus granulosus calcium dependent protein kinase 0.0025 0.0531 0.0613
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0027 0.0585 0.0675
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Schistosoma mansoni hypothetical protein 0.0317 0.866 1
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0131 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Schistosoma mansoni glucose transport protein 0.0086 0.2235 0.258
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0131 0.0151
Trypanosoma brucei glucose transporter, putative 0.0027 0.0585 0.2302
Brugia malayi Major Facilitator Superfamily protein 0.0012 0.018 0.0308
Brugia malayi Ets-domain containing protein 0.0071 0.1821 0.3115
Plasmodium falciparum calcium-dependent protein kinase 4 0.0027 0.0585 0.0585
Brugia malayi major facilitator superfamily protein 0.0012 0.018 0.0308
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0131 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0027 0.0585 0.0675
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0452 0.115
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.1203 0.4731
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0027 0.0585 0.0675
Brugia malayi Sugar transporter family protein 0.0012 0.018 0.0308
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0019 0.0377 0.1484
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Brugia malayi major facilitator superfamily protein 0.0012 0.018 0.0308
Echinococcus multilocularis importin subunit beta 1 0.003 0.067 0.0773
Loa Loa (eye worm) hypothetical protein 0.0019 0.0377 0.0436
Giardia lamblia Kinase, PLK 0.0097 0.2543 1
Trypanosoma cruzi hexose transporter, putative 0.0027 0.0585 0.1715
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0131 0.0151
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0026 0.0561 0.0648
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0027 0.0585 0.1
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Giardia lamblia Prolyl-tRNA synthetase 0.0026 0.0561 0.1613
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0086 0.2235 0.258
Trichomonas vaginalis sugar transport protein, putative 0.0012 0.018 0.0708
Leishmania major hypothetical protein, conserved 0.0012 0.018 0.0708
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2543 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0027 0.0585 0.0585
Schistosoma mansoni gabp alpha 0.0071 0.1821 0.2103
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1116 0.1289
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0012 0.018 0.0708
Echinococcus multilocularis calcium dependent protein kinase 0.0025 0.0531 0.0613
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1116 0.1289
Echinococcus multilocularis ets variant gene 4 0.001 0.0131 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Plasmodium falciparum calcium-dependent protein kinase 1 0.0027 0.0585 0.0585
Schistosoma mansoni hypothetical protein 0.0086 0.2235 0.258
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Plasmodium vivax proline--tRNA ligase, putative 0.003 0.068 0.068
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0131 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Brugia malayi Cam kinase protein 1 0.0027 0.0585 0.1
Plasmodium vivax hexose transporter 0.0086 0.2235 0.2235
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0027 0.0585 0.0885
Schistosoma mansoni glucose transport protein 0.0086 0.2235 0.258
Brugia malayi Ets-domain containing protein 0.001 0.0131 0.0223
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0131 0.0223
Loa Loa (eye worm) hypothetical protein 0.0026 0.0561 0.0648
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.003 0.068 0.2116
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.2543 1
Trichomonas vaginalis sugar transporter, putative 0.0027 0.0585 0.2302
Plasmodium vivax lysine--tRNA ligase, putative 0.0019 0.0377 0.0377
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0019 0.0377 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0585 0.2302
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0086 0.2235 0.258
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0016 0.0297 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0513 0.1411
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Giardia lamblia Lysyl-tRNA synthetase 0.0019 0.0377 0.0836
Leishmania major glucose transporter/membrane transporter D2, putative 0.0027 0.0585 0.2302
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.067 0.2633
Trypanosoma brucei glucose transporter, putative 0.0027 0.0585 0.2302
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2543 1
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.1821 0.2103
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0131 0.0151
Plasmodium falciparum importin beta, putative 0.003 0.067 0.067
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0086 0.2235 0.258
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.018 0.0708
Echinococcus granulosus synaptic vesicle 2 protein 0.0012 0.018 0.0208
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0585 0.0675
Schistosoma mansoni hypothetical protein 0.001 0.0131 0.0151
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.003 0.068 0.2674
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0026 0.0561 0.096
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2543 1
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0452 0.115
Trichomonas vaginalis myo-inositol transporter, putative 0.0012 0.018 0.0708
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.018 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.2235 0.8788
Loa Loa (eye worm) hypothetical protein 0.001 0.0131 0.0151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1116 0.191
Leishmania major glucose transporter, lmgt2 0.0027 0.0585 0.2302
Echinococcus multilocularis General substrate transporter 0.0074 0.1899 0.2192
Entamoeba histolytica hypothetical protein 0.0019 0.0377 0.1484
Trypanosoma cruzi hexose transporter 0.0027 0.0585 0.1715
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0027 0.0585 0.0585
Echinococcus granulosus solute carrier family 22 0.0012 0.018 0.0208
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1116 0.1289
Schistosoma mansoni sugar transporter 0.0012 0.018 0.0208
Trypanosoma cruzi hexose transporter, putative 0.0027 0.0585 0.1715
Loa Loa (eye worm) major facilitator superfamily transporter 0.0012 0.018 0.0208
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0513 0.2019
Schistosoma mansoni ran 0.0022 0.0452 0.0521
Loa Loa (eye worm) sugar transporter 0.0086 0.2235 0.258
Loa Loa (eye worm) hypothetical protein 0.0012 0.018 0.0208
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0452 0.0521
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0012 0.018 0.018
Echinococcus multilocularis solute carrier family 22 0.0012 0.018 0.0208
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0086 0.2235 0.258
Leishmania major importin beta-1 subunit, putative 0.0024 0.0513 0.2019
Entamoeba histolytica hypothetical protein 0.0024 0.0513 0.2019
Schistosoma mansoni ran 0.0022 0.0452 0.0521
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0026 0.0561 0.0648
Trypanosoma brucei THT1 - hexose transporter, putative 0.0027 0.0585 0.2302
Schistosoma mansoni kinase 0.005 0.1238 0.143
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0131 0.0151
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0131 0.0151
Echinococcus multilocularis solute carrier family 22 0.0012 0.018 0.0208
Echinococcus multilocularis solute carrier family 22 0.0012 0.018 0.0208
Schistosoma mansoni sugar transporter 0.0012 0.018 0.0208
Loa Loa (eye worm) hypothetical protein 0.001 0.0131 0.0151
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0016 0.0297 1
Schistosoma mansoni glucose transport protein 0.0086 0.2235 0.258
Toxoplasma gondii lysine-tRNA ligase 0.0019 0.0377 0.0571
Plasmodium falciparum proline--tRNA ligase 0.003 0.068 0.068
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0131 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Trichomonas vaginalis glucose transporter, putative 0.0027 0.0585 0.2302
Schistosoma mansoni sugar transporter 0.0012 0.018 0.0208
Loa Loa (eye worm) sugar transporter 0.0012 0.018 0.0208
Treponema pallidum prolyl-tRNA synthetase 0.0009 0.0097 0.5
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0027 0.0585 0.0675
Brugia malayi Ets-domain containing protein 0.0071 0.1821 0.3115
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.003 0.068 0.2116
Brugia malayi hypothetical protein 0.0012 0.018 0.0308
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Trypanosoma brucei polo-like protein kinase 0.0097 0.2543 1
Brugia malayi hypothetical protein 0.0012 0.018 0.0308
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.003 0.068 0.2674
Leishmania major myo-inositol/proton symporter (MIT) 0.0012 0.018 0.0708
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Schistosoma mansoni hypothetical protein 0.001 0.0131 0.0151
Trichomonas vaginalis ran, putative 0.0022 0.0452 0.1776
Schistosoma mansoni glucose transporter 0.0012 0.018 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1116 0.1289
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Trypanosoma brucei glucose transporter, putative 0.0027 0.0585 0.2302
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0027 0.0585 0.0885
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0011 0.0138 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2543 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2543 1
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Schistosoma mansoni ets-related 0.0216 0.5847 0.6751
Leishmania major GTP-binding protein, putative 0.0022 0.0452 0.1776
Brugia malayi hypothetical protein 0.0012 0.018 0.0308
Echinococcus granulosus protein C ets 2 0.001 0.0131 0.0151
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0452 0.115
Trichomonas vaginalis sugar transporter, putative 0.0012 0.018 0.0708
Mycobacterium ulcerans sugar transporter 0.0012 0.018 0.2954
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0452 0.0452
Trypanosoma cruzi hexose transporter, putative 0.0027 0.0585 0.1715
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0249 0.0293
Plasmodium falciparum calcium-dependent protein kinase 2 0.0027 0.0585 0.0585
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0019 0.0377 0.3046

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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