TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 289.335 | Formula: C17H15N5
H donors: 1 H acceptors: 3 LogP: 3.05 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CCn1nc(c2c1ncnc2N)c1ccc2c(c1)cccc2
InChi: 1S/C17H15N5/c1-2-22-17-14(16(18)19-10-20-17)15(21-22)13-8-7-11-5-3-4-6-12(11)9-13/h3-10H,2H2,1H3,(H2,18,19,20)
InChiKey: PCPZDHWQPMHSIG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	Starlite/ChEMBL	References
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0025	0.0193	0.0277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Plasmodium falciparum	glutathione reductase	0.0037	0.0599	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0095	0.2531	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0085	0.2213	0.6399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0122	0.3459	0.97
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0093	0.2482	0.4036
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2482	0.7176
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2482	0.7176
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.2482	0.3565
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.096	0.096
Loa Loa (eye worm)	transcription factor SMAD2	0.0126	0.3566	0.5799
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.3459	1
Trypanosoma brucei	trypanothione reductase	0.0037	0.0599	0.2412
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0812	0.2278
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0025	0.0193	0.0557
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0025	0.0193	0.0193
Loa Loa (eye worm)	phosphatidylinositol 3	0.0025	0.0193	0.0313
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0025	0.0193	0.0587
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0122	0.3459	1
Brugia malayi	MH2 domain containing protein	0.0126	0.3566	1
Brugia malayi	glutathione reductase	0.0037	0.0599	0.1679
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.096	0.096
Schistosoma mansoni	hypothetical protein	0.0165	0.4881	0.701
Schistosoma mansoni	kinase	0.0047	0.0937	0.1346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0599	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0122	0.3459	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.0615	0.0615
Giardia lamblia	Kinase, PLK	0.0093	0.2482	1
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2482	0.7176
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0095	0.2531	1
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0599	0.0974
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2482	0.7176
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Loa Loa (eye worm)	phosphatidylinositol 3	0.0025	0.0193	0.0313
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0044	0.0812	0.2348
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0025	0.0193	0.0777
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0025	0.0193	0.0587
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0025	0.0193	0.0557
Echinococcus multilocularis	geminin	0.0165	0.4881	0.4881
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0093	0.2482	0.7552
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0093	0.2482	0.2482
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0098	0.2647	0.7652
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0553	0.09
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.096	0.156
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0742	0.1206
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0081	0.2058	0.2058
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0044	0.0812	0.1167
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0025	0.0193	0.0277
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0227	0.6962	0.6962
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0085	0.221	0.8342
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0025	0.0193	0.0587
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.096	0.1378
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0057	0.1245	0.3601
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0599	0.1731
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0036	0.0553	0.1599
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.096	0.096
Loa Loa (eye worm)	MH2 domain-containing protein	0.0126	0.3566	0.5799
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0599	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.096	0.1378
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2482	0.7176
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0193	0.0541
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0025	0.0193	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0081	0.2058	0.3346
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2482	0.7176
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.096	0.096
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0227	0.6962	0.6962
Trypanosoma cruzi	target of rapamycin kinase 3	0.0025	0.0193	0.0557
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0085	0.221	0.8342
Echinococcus granulosus	geminin	0.0165	0.4881	0.4881
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0896	0.259
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.2844	0.7974
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0025	0.0193	0.0193
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.2482	0.7176
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0025	0.0193	0.0587
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0025	0.0193	0.0557
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0081	0.2058	0.2058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Schistosoma mansoni	hypothetical protein	0.0165	0.4881	0.701
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0025	0.0193	0.322
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0122	0.3459	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0044	0.0812	0.2348
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0081	0.2058	0.577
Trypanosoma brucei	polo-like protein kinase	0.0093	0.2482	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.32	0.9251
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0025	0.0193	0.0557
Brugia malayi	Thioredoxin reductase	0.0037	0.0599	0.1679
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0896	0.259
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0044	0.0812	0.2348
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Loa Loa (eye worm)	phosphatidylinositol 3	0.0202	0.615	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Mycobacterium tuberculosis	Probable oxidoreductase	0.0095	0.2531	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0032	0.0412	0.0957
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.2482	0.7176
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0025	0.0193	0.0777
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.2482	0.7176
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.0615	0.0615
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0025	0.0193	0.0193
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0095	0.2531	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.3459	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0025	0.0193	0.0557
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0044	0.0812	0.2348
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.3028	0.8753
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0599	0.0974
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0193	0.0541
Leishmania major	trypanothione reductase	0.0037	0.0599	0.1822
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0093	0.2482	0.5
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0599	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Leishmania major	hypothetical protein, conserved	0.0117	0.3287	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0093	0.2482	0.2482
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0025	0.0193	0.0193
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0025	0.0193	0.0777
Brugia malayi	serine/threonine-protein kinase plk-2	0.0093	0.2482	0.696
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0093	0.2482	0.7176
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0061	0.1401	0.5278
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0085	0.221	0.8342
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0085	0.2213	0.6399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0122	0.3459	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0044	0.0812	0.3272
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0025	0.0193	0.0557
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0025	0.0193	0.0777
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.096	0.1378
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0317	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0025	0.0193	0.0777
Mycobacterium tuberculosis	Probable reductase	0.0085	0.221	0.8342
Mycobacterium tuberculosis	Probable dehydrogenase	0.0085	0.221	0.8342
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0599	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0193	0.0557
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0044	0.0812	0.2348
Entamoeba histolytica	hypothetical protein	0.0098	0.2647	0.7652
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0227	0.6962	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.096	0.2691
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0044	0.0812	0.2348
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0085	0.221	0.8342

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Inhibition of recombinant c-Abl by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)		Inhibition of recombinant PI3Kgamma by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)		Inhibition of recombinant VEGFR2 by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)		Inhibition of recombinant c-Src by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)		Inhibition of recombinant PI4Kbeta by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)		Inhibition of recombinant PI3Kbeta by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)		Inhibition of recombinant EphB4R by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)		Inhibition of recombinant HCK by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)		Inhibition of recombinant EGFR by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)		Inhibition of recombinant PI3Kalpha by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)	= 0.21 uM	Inhibition of DNA-PK by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971
IC50 (binding)	= 0.75 uM	Inhibition of recombinant PI3Kdelta by radioactive phosphotransfer assay in presence of 10 uM ATP	ChEMBL.	18849971

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1242851

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1016996