Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.00958295 | 0.0722194 | 0.0600431 |
Schistosoma mansoni | hypothetical protein | 0.0913727 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0139869 | 0.122175 | 0.0398 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0123251 | 0.103325 | 0.165896 |
Echinococcus granulosus | chromobox protein 2 | 0.0187575 | 0.176291 | 0.299841 |
Loa Loa (eye worm) | hypothetical protein | 0.0540783 | 0.576952 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0123251 | 0.103325 | 0.165896 |
Toxoplasma gondii | PLU-1 family protein | 0.00440392 | 0.0134712 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0523809 | 0.557698 | 1 |
Echinococcus multilocularis | chromobox protein 2 | 0.0187575 | 0.176291 | 0.299841 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0413981 | 0.433114 | 0.771299 |
Brugia malayi | jmjC domain containing protein | 0.0139869 | 0.122175 | 0.0398 |
Brugia malayi | mbt repeat family protein | 0.0313008 | 0.318575 | 0.454472 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0290821 | 0.293408 | 0.514836 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0450066 | 0.474047 | 0.467144 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0117883 | 0.0972359 | 0.154718 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0290821 | 0.293408 | 0.284135 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0523809 | 0.557698 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0540783 | 0.576952 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0450066 | 0.474047 | 0.84644 |
Brugia malayi | mbt repeat family protein | 0.0540783 | 0.576952 | 1 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0413981 | 0.433114 | 0.771299 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.00958295 | 0.0722194 | 0.108795 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.00764007 | 0.0501805 | 0.0683375 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0123251 | 0.103325 | 0.165896 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0450066 | 0.474047 | 0.84644 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.00958295 | 0.0722194 | 0.0600431 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0290821 | 0.293408 | 0.284135 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0313008 | 0.318575 | 0.454472 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0123251 | 0.103325 | 0.0915568 |
Schistosoma mansoni | hypothetical protein | 0.0413981 | 0.433114 | 0.425674 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0123251 | 0.103325 | 0.165896 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0290821 | 0.293408 | 0.514836 |
Schistosoma mansoni | chromobox protein | 0.0187575 | 0.176291 | 0.16548 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0117883 | 0.0972359 | 0.154718 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 48.6 nM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 as LDH reporter activity | ChEMBL. | 18562202 |
IC50 (functional) | = 255.2 nM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 as LDH activity | ChEMBL. | 18562202 |
Ratio IC50 (functional) | = 0.3 | Relative selectivity against Plasmodium falciparum D10 as IC50 ratio compared to chloroquine | ChEMBL. | 18562202 |
Ratio IC50 (functional) | = 0.9 | Relative selectivity against Plasmodium falciparum W2 as IC50 ratio compared to chloroquine | ChEMBL. | 18562202 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18562202 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.