TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 400.855 | Formula: C21H21ClN2O4
H donors: 1 H acceptors: 2 LogP: 2.87 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1/C(=C(\C(=O)N1CCOCC1)/NC(=O)c1ccccc1)/Cl
InChi: 1S/C21H21ClN2O4/c1-27-17-10-6-5-9-16(17)18(22)19(21(26)24-11-13-28-14-12-24)23-20(25)15-7-3-2-4-8-15/h2-10H,11-14H2,1H3,(H,23,25)/b19-18-
InChiKey: PJOZOAFHTRHVHJ-HNENSFHCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2075	0.9756
Echinococcus granulosus	geminin	0.0198	0.4402	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0451	0.2123
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Leishmania major	hypothetical protein, conserved	0.0026	0.0313	0.133
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0042	0.0058
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0452	0.0411
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0453	0.2022
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2126	0.481
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2126	0.481
Leishmania major	protein kinase, putative	0.0032	0.0451	0.2012
Echinococcus multilocularis	musashi	0.0028	0.0356	0.0772
Echinococcus multilocularis	General substrate transporter	0.0088	0.1785	0.4032
Plasmodium falciparum	hexose transporter	0.0102	0.2126	0.2093
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0549	0.2494
Schistosoma mansoni	protein kinase	0.0032	0.0451	0.0938
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0451	0.0991
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2075	0.9756
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0223	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0429	0.2017
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0243	1
Brugia malayi	hypothetical protein	0.0017	0.0096	0.0258
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0453	0.2022
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0453	0.2022
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0452	0.0628
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.2075	1
Schistosoma mansoni	kinase	0.0052	0.0931	0.2038
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0451	0.1963
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0452	0.0411
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0453	0.1973
Schistosoma mansoni	ap endonuclease	0.0022	0.0223	0.0415
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0223	0.9026
Trypanosoma cruzi	polo-like protein kinase, putative	0.01	0.2075	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0166	0.3627	0.55
Plasmodium falciparum	protein kinase 7	0.0289	0.656	0.6545
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2075	0.9756
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.097	0.4453
Echinococcus granulosus	solute carrier family 22	0.0014	0.0042	0.0058
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0166	0.3627	0.36
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2126	0.481
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0647	0.2901
Trypanosoma brucei	polo-like protein kinase	0.01	0.2075	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0243	0.3046
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2075	0.9756
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0243	1
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0042	0.0058
Brugia malayi	serine/threonine-protein kinase plk-2	0.01	0.2075	0.9756
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0429	0.1855
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0139	0.0278
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0042	0.0058
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.09	0.4115
Plasmodium vivax	hexose transporter	0.0102	0.2126	0.2093
Entamoeba histolytica	protein kinase, putative	0.0032	0.0451	0.1233
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.097	0.2174
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0453	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Echinococcus multilocularis	lamin	0.0028	0.0356	0.0772
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.2126	0.481
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0429	0.1901
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0549	0.2494
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0139	0.0464
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0243	0.0961
Leishmania major	glucose transporter, lmgt1	0.0032	0.0453	0.2022
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0549	0.2494
Echinococcus multilocularis	lamin dm0	0.0028	0.0356	0.0772
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0223	1
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0139	0.0464
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0052	0.0046
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0356	0.0718
Brugia malayi	Cam kinase protein 1	0.0032	0.0451	0.1963
Loa Loa (eye worm)	hypothetical protein	0.004	0.0647	0.3042
Loa Loa (eye worm)	sugar transporter	0.0102	0.2126	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0549	0.0778
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0451	0.0938
Echinococcus granulosus	solute carrier family 22	0.0014	0.0042	0.0058
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0139	0.0278
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0451	0.2123
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0452	0.0411
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0452	0.0411
Entamoeba histolytica	protein kinase, putative	0.0032	0.0451	0.1233
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0313	0.133
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0451	0.2123
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0429	0.1855
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0452	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0356	0.1672
Schistosoma mansoni	hypothetical protein	0.0018	0.0139	0.0222
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2126	0.481
Schistosoma mansoni	protein kinase	0.0032	0.0451	0.0938
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0453	0.2022
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0453	0.1973
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.0985
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0223	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0139	0.0278
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0429	0.0887
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0429	0.0939
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0223	0.0889
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.0985
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0453	0.2022
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0042	0.0058
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.09	0.4115
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0398	0.0869
Loa Loa (eye worm)	sugar transporter	0.0014	0.0042	0.0199
Onchocerca volvulus	Serine\/threonine kinase homolog	0.01	0.2075	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0344	0.1616
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Giardia lamblia	Kinase, PLK	0.01	0.2075	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0139	0.0278
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0453	0.2022
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0042	0.0058
Leishmania major	glucose transporter, lmgt2	0.0032	0.0453	0.2022
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0452	0.0411
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.097	0.2174
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.0961
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0549	0.0509
Echinococcus granulosus	solute carrier family 22	0.0014	0.0042	0.0058
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0243	0.0307
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0223	0.0889
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.01	0.2075	0.9761
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0452	0.0628
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0052	0.0244
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.01	0.2075	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2126	0.481
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.1084	0.5
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0243	0.0201
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.097	0.2129
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0452	0.0411
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0223	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Echinococcus granulosus	lamin	0.0028	0.0356	0.0772
Echinococcus granulosus	intermediate filament protein	0.0028	0.0356	0.0772
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0453	0.2022
Schistosoma mansoni	hypothetical protein	0.0018	0.0139	0.0222
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0398	0.0869
Leishmania major	glucose transporter, lmgt3	0.0032	0.0453	0.2022
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0452	0.0411
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0042	0.0199
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0313	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.1084	0.51
Echinococcus granulosus	GPCR family 2	0.0018	0.0139	0.0278
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.097	0.2129
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0313	0.1471
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0223	0.1049
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.2126	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0429	0.0939
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0161	0.6566
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0453	0.1973
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0451	0.1963
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0549	0.2494
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0313	0.133
Schistosoma mansoni	hypothetical protein	0.0198	0.4402	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0223	0.047
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1084	0.51
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.2075	0.4663
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0991
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0223	0.047
Echinococcus granulosus	lamin dm0	0.0028	0.0356	0.0772
Schistosoma mansoni	lamin	0.0028	0.0356	0.0718
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0991
Echinococcus granulosus	solute carrier family 22	0.0014	0.0042	0.0058
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.01	0.2075	0.4694
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0453	0.2022
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0453	0.2022
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.097	0.4564
Entamoeba histolytica	serine/threonine protein kinase, putative	0.01	0.2075	1
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2075	0.9756
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0453	0.2022
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2075	0.9756
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0549	0.2494
Echinococcus multilocularis	geminin	0.0198	0.4402	1
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0453	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0005	0.0024
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0243	0.0514
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0356	0.1503
Brugia malayi	intermediate filament protein	0.0028	0.0356	0.1503
Schistosoma mansoni	glucose transport protein	0.0102	0.2126	0.478
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.1141
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0166	0.3627	0.36
Schistosoma mansoni	protein kinase	0.0032	0.0451	0.0938
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0356	0.1672
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0453	0.2022
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0223	0.0182
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0429	1
Schistosoma mansoni	ap endonuclease	0.0022	0.0223	0.0415
Schistosoma mansoni	hypothetical protein	0.0102	0.2126	0.478
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0161	0.6566
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0005	0.0024
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0313	0.0272
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0549	0.0509
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.01	0.2075	0.4694
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0429	0.2017
Entamoeba histolytica	hypothetical protein	0.0023	0.0243	0.0105
Toxoplasma gondii	protein kinase, putative	0.0289	0.656	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0991
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0223	0.0868
Brugia malayi	Sugar transporter family protein	0.0102	0.2126	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0243	0.0201
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0453	0.1973
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0243	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0991
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0356	0.1672
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.008
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2126	0.481
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0452	0.0628
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0223	0.0889
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0991
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0313	0.0272
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0453	0.2022
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0991
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0453	0.2022
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0453	0.2022
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0453	0.2022
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0313	0.133
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0243	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0139	0.0654
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0452	0.0411
Schistosoma mansoni	hypothetical protein	0.004	0.0647	0.1386
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0243	0.0985
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0429	0.0887
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.097	0.2174
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0243	0.0514
Echinococcus granulosus	General substrate transporter	0.0088	0.1785	0.4032
Brugia malayi	hypothetical protein	0.0026	0.0313	0.1298
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.1084	0.5
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0429	0.1111
Schistosoma mansoni	hypothetical protein	0.0018	0.0139	0.0222
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0451	0.2012
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0243	0.0459
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0042	0.0058
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0042	0.0058
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0223	0.0889
Schistosoma mansoni	glucose transport protein	0.0102	0.2126	0.478
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0451	0.0991
Trypanosoma cruzi	hexose transporter	0.0032	0.0453	0.2022
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0176	0.0641
Toxoplasma gondii	exonuclease III APE	0.0022	0.0223	0.0277
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.2075	0.9756
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0435	1	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0313	0.0415
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0042	0.0058
Schistosoma mansoni	glucose transport protein	0.0102	0.2126	0.478
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0139	0.0654
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.097	0.2174
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2126	0.481
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0223	0.0868
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0453	0.2022
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0453	0.1973
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.097	0.2129
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Onchocerca volvulus		0.0028	0.0356	0.1541
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0453	0.2022
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0112	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0292	0.1375
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.2126	0.3197
Schistosoma mansoni	lamin	0.0028	0.0356	0.0718
Onchocerca volvulus		0.0028	0.0356	0.1541
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0223	0.5
Schistosoma mansoni	hypothetical protein	0.0018	0.0139	0.0222
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0223	0.0889
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0429	0.1855
Schistosoma mansoni	hypothetical protein	0.0198	0.4402	1
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0139	0.0278

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1807427

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1027136