Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium channel, voltage-dependent, N type, alpha 1B subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | transporter, cation channel family protein | 0.0024 | 0.0108 | 0.0306 |
Onchocerca volvulus | 0.0293 | 1 | 0.5 | |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0117 | 0.353 | 1 |
Echinococcus multilocularis | General substrate transporter | 0.0101 | 0.2923 | 0.7574 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0116 | 0.3491 | 0.9844 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 1 | 1 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0071 | 0.1815 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0117 | 0.353 | 1 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0117 | 0.353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0108 | 0.0108 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0116 | 0.3491 | 0.9844 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0117 | 0.353 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0116 | 0.3491 | 0.9886 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0116 | 0.3491 | 0.9886 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0117 | 0.353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3491 | 0.3491 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0117 | 0.353 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0117 | 0.353 | 1 |
Leishmania major | glucose transporter, lmgt3 | 0.0036 | 0.0551 | 0.5 |
Schistosoma mansoni | glucose transport protein | 0.0117 | 0.353 | 1 |
Echinococcus granulosus | General substrate transporter | 0.0101 | 0.2923 | 0.8226 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0036 | 0.0551 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0116 | 0.3491 | 0.9844 |
Brugia malayi | Sugar transporter family protein | 0.0117 | 0.353 | 0.006 |
Plasmodium falciparum | hexose transporter | 0.0117 | 0.353 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0116 | 0.3491 | 0.9844 |
Plasmodium vivax | hexose transporter | 0.0117 | 0.353 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0116 | 0.3491 | 0.9886 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0071 | 0.1815 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0049 | 0.1027 | 0.2686 |
Loa Loa (eye worm) | calcium channel | 0.0116 | 0.3491 | 0.3491 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0117 | 0.353 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.353 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0116 | 0.3491 | 0.9886 |
Loa Loa (eye worm) | sugar transporter | 0.0117 | 0.353 | 0.353 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0117 | 0.353 | 1 |
Leishmania major | glucose transporter, lmgt1 | 0.0036 | 0.0551 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0117 | 0.353 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0116 | 0.3491 | 0.9844 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0116 | 0.3491 | 0.9844 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0024 | 0.0108 | 0.0108 |
Schistosoma mansoni | glucose transport protein | 0.0117 | 0.353 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0117 | 0.353 | 1 |
Leishmania major | glucose transporter, lmgt2 | 0.0036 | 0.0551 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.3 uM | In vitro inhibition against N-type calcium influx in IMR-32 cells | ChEMBL. | 11514140 |
IC50 (functional) | = 3.3 uM | In vitro inhibition against N-type calcium influx in IMR-32 cells | ChEMBL. | 11514140 |
IC50 (functional) | = 16 uM | In vitro inhibition against L-type calcium influx in mouse pituitary tumor derived cells (AtT-20) | ChEMBL. | 11514140 |
Selectivity ratio (functional) | = 4.8 | Selectivity ratio between the L-type to N-type calcium influx | ChEMBL. | 11514140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.