Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human herpesvirus 2 | Thymidine kinase | Starlite/ChEMBL | References |
Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) | Thymidine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Giardia lamblia | Deoxynucleoside kinase | Get druggable targets OG5_131626 | All targets in OG5_131626 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0569 | 0.0752 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0065 | 0.0847 | 0.5 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0065 | 0.0847 | 0.5 |
Onchocerca volvulus | 0.0053 | 0.0569 | 1 | |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0065 | 0.0847 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0836 | 0.1104 |
Echinococcus granulosus | hypothetical protein | 0.0065 | 0.0836 | 0.1063 |
Echinococcus granulosus | tumor protein p63 | 0.0364 | 0.7863 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0569 | 0.0752 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0065 | 0.0847 | 0.112 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0065 | 0.0847 | 0.1077 |
Leishmania major | protein kinase, putative | 0.0065 | 0.0847 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0065 | 0.0847 | 0.5 |
Schistosoma mansoni | ubiquitin ligase sina (ec 6.3.2.-) (seven in absentia homolog)(smsina) | 0.0351 | 0.7567 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0364 | 0.7863 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0065 | 0.0847 | 0.112 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0065 | 0.0847 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.7567 | 1 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0065 | 0.0847 | 0.5 |
Echinococcus granulosus | e3 ubiquitin protein ligase siah1 | 0.0351 | 0.7567 | 0.9624 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.0069 | 0.0091 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0065 | 0.0847 | 0.5 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0065 | 0.0847 | 0.5 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0065 | 0.0847 | 0.5 |
Echinococcus multilocularis | 0.0065 | 0.0836 | 0.1063 | |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0065 | 0.0847 | 0.112 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0065 | 0.0847 | 0.5 |
Echinococcus multilocularis | e3 ubiquitin protein ligase siah1 | 0.0351 | 0.7567 | 0.9624 |
Leishmania major | protein kinase, putative | 0.0065 | 0.0847 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0065 | 0.0847 | 0.112 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0065 | 0.0847 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.0069 | 0.0091 |
Brugia malayi | Ubiquitin ligase sia-1 | 0.0351 | 0.7567 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.34 uM | Inhibitory concentration against herpes simplex virus type 2 thymidine kinase | ChEMBL. | 15916444 |
IC50 (binding) | = 5.2 uM | Inhibitory concentration against herpes simplex virus type 1 thymidine kinase | ChEMBL. | 15916444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.