Detailed view for Bm1_36670

Basic information

TDR Targets ID: 233762
Brugia malayi, Ubiquitin ligase sia-1
Source Database / ID:  GenBank

pI: 6.8319 | Length (AA): 323 | MW (Da): 35438 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03145   Seven in absentia protein family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0005515   protein binding  
GO:0004842   ubiquitin-protein ligase activity  
GO:0008270   zinc ion binding  
GO:0006511   ubiquitin-dependent protein catabolic process  
GO:0016567   protein ubiquitination  
GO:0007275   multicellular organismal development  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
62 135 4ayc (A) 384 461 23.00 0 0.61 0.480302 -0.69
131 322 4ca1 (A) 91 281 78.00 0 1 1.50223 -0.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130260)

Species Accession Gene Product
Arabidopsis thaliana AT4G27880   E3 ubiquitin-protein ligase SINAT4
Arabidopsis thaliana AT2G41980   putative E3 ubiquitin-protein ligase SINAT1
Arabidopsis thaliana AT3G58040   E3 ubiquitin-protein ligase SINAT2
Arabidopsis thaliana AT3G61790   E3 ubiquitin-protein ligase SINAT3
Brugia malayi Bm1_36670   Ubiquitin ligase sia-1
Caenorhabditis elegans CELE_Y37E11AR.2   Protein SIAH-1
Drosophila melanogaster Dmel_CG9949   seven in absentia
Drosophila melanogaster Dmel_CG13030   sina homologue
Echinococcus granulosus EgrG_001011300   e3 ubiquitin protein ligase siah1
Echinococcus multilocularis EmuJ_001011300   e3 ubiquitin protein ligase siah1
Homo sapiens ENSG00000181788   siah E3 ubiquitin protein ligase 2
Homo sapiens ENSG00000196470   siah E3 ubiquitin protein ligase 1
Loa Loa (eye worm) LOAG_09726   hypothetical protein
Mus musculus ENSMUSG00000036840   seven in absentia 1A
Mus musculus ENSMUSG00000040749   seven in absentia 1B
Mus musculus ENSMUSG00000036432   seven in absentia 2
Oryza sativa 4327774   Os01g0234900
Oryza sativa 4338181   Os05g0238200
Oryza sativa 4328179   Os02g0128800
Oryza sativa 4329066   Os02g0293400
Schistosoma japonicum Sjp_0118050   E3 ubiquitin-protein ligase sina, putative
Schistosoma japonicum Sjp_0107880   E3 ubiquitin-protein ligase sina, putative
Schistosoma japonicum Sjp_0310480   ko:K04506 E3 ubiquitin-protein ligase SIAH1, putative
Schistosoma mansoni Smp_000650   ubiquitin ligase sina (ec 6.3.2.-) (seven in absentia homolog)(smsina)
Schmidtea mediterranea mk4.000565.00   E3 ubiquitin-protein ligase siah-1
Schmidtea mediterranea mk4.000565.01   E3 ubiquitin-protein ligase siah-1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human Blymphotropic virus) Human herpesvirus 6 protease Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1382 0.3081 0.4843
0.1653 0.7822 1
0.0101 0.4698 0.4904
0.061 0.466 1
0.0351 0.7567 1
0.1382 0.3081 0.4843
0.061 0.466 1
0.0351 0.7567 1
0.0915 0.339 1
0.1693 0.9736 1
0.1653 0.7822 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_36670 (Brugia malayi), Ubiquitin ligase sia-1
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