Detailed information for compound 1033634

Basic information

Technical information
  • TDR Targets ID: 1033634
  • Name: 5-butyl-2-(furan-2-yl)-1-methylimidazo[4,5-c] quinolin-4-one hydrochloride
  • MW: 357.834 | Formula: C19H20ClN3O2
  • H donors: 0 H acceptors: 2 LogP: 3.92 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCn1c(=O)c2nc(n(c2c2c1cccc2)C)c1ccco1.Cl
  • InChi: 1S/C19H19N3O2.ClH/c1-3-4-11-22-14-9-6-5-8-13(14)17-16(19(22)23)20-18(21(17)2)15-10-7-12-24-15;/h5-10,12H,3-4,11H2,1-2H3;1H
  • InChiKey: NJFPOIFTGQHLEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-butyl-2-(2-furyl)-1-methyl-imidazo[4,5-c]quinolin-4-one hydrochloride
  • 5-butyl-2-(2-furyl)-1-methyl-4-imidazo[4,5-c]quinolinone hydrochloride
  • 5-butyl-2-(furan-2-yl)-1-methyl-imidazo[4,5-c]quinolin-4-one hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0083 0.0315
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0104 0.0397
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0018 0.0013
Schistosoma mansoni protein kinase 0.0061 0.0167 0.0162
Schistosoma mansoni lamin 0.003 0.0053 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0018 0.0038
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0061 0.0167 0.0572
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.3537
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0018 0.0069
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.5545
Onchocerca volvulus 0.003 0.0053 0.0132
Schistosoma mansoni lamin 0.003 0.0053 0.0047
Brugia malayi steroid hormone receptor 0.0021 0.0018 0.0069
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0018 0.0048
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0018 0.0048
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0018 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0053 0.3537
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0018 0.0038
Schistosoma mansoni phosphoglucomutase 0.0719 0.2622 0.2618
Echinococcus granulosus lamin dm0 0.003 0.0053 0.018
Schistosoma mansoni hypothetical protein 0.0038 0.0083 0.0077
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Toxoplasma gondii ribonuclease HI protein 0.0719 0.2622 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0104 0.0099
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0018 0.0038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0018 0.0048
Echinococcus granulosus geminin 0.0191 0.0652 0.2469
Loa Loa (eye worm) intermediate filament protein 0.003 0.0053 0.3537
Leishmania major ribonuclease H1, putative 0.0719 0.2622 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0018 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0104 0.0099
Onchocerca volvulus 0.003 0.0053 0.0132
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Trypanosoma brucei ribonuclease H1 0.0719 0.2622 0.2497
Schistosoma mansoni hypothetical protein 0.0061 0.0167 0.0162
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0061 0.0167 0.0483
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0018 0.0069
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0061 0.0167 0.0618
Echinococcus multilocularis RNA directed DNA polymerase 0.0061 0.0167 0.0483
Trypanosoma cruzi ribonuclease H1, putative 0.0719 0.2622 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0018 0.0038
Schistosoma mansoni coup transcription factor 0.0021 0.0018 0.0013
Schistosoma mansoni phosphoglucomutase 0.0719 0.2622 0.2618
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0149 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0018 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0018 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0018 0.0069
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0018 0.0048
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0061 0.0167 0.0483
Brugia malayi hypothetical protein 0.0061 0.0167 0.0638
Brugia malayi nuclear hormone receptor 0.0021 0.0018 0.0069
Trypanosoma cruzi ribonuclease H1, putative 0.0719 0.2622 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0018 0.1221
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0018 0.0069
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0018 0.1221
Schistosoma mansoni hypothetical protein 0.0191 0.0652 0.0646
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0018 0.1221
Brugia malayi hypothetical protein 0.0061 0.0167 0.0638
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0018 0.0013
Brugia malayi ecdysteroid receptor 0.0021 0.0018 0.0069
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0018 0.0048
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Brugia malayi intermediate filament protein 0.003 0.0053 0.0201
Brugia malayi reverse transcriptase 0.0061 0.0167 0.0638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0104 0.0376
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0018 0.0013
Brugia malayi RNase H family protein 0.0719 0.2622 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0018 0.0069
Treponema pallidum ribonuclease H (rnhA) 0.0719 0.2622 0.5
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0061 0.0167 0.0618
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0018 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.078 0.285 0.2728
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0018 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0018 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0018 0.0069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.1221
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Brugia malayi reverse transcriptase 0.0061 0.0167 0.0638
Onchocerca volvulus 0.0061 0.0167 0.0572
Onchocerca volvulus Ribonuclease H1 homolog 0.0719 0.2622 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0018 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0018 0.0048
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0061 0.0167 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0018 0.0069
Echinococcus granulosus lamin 0.003 0.0053 0.018
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0719 0.2622 0.5
Schistosoma mansoni hypothetical protein 0.0191 0.0652 0.0646
Schistosoma mansoni phosphoglucomutase 0.0719 0.2622 0.2618
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.1221
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0018 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0018 0.0069
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0018 0.0013
Echinococcus multilocularis lamin 0.003 0.0053 0.0141
Echinococcus multilocularis ribonuclease H1 0.0719 0.2622 0.7829
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0375
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0018 0.0048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0149 0.0568
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.1221
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.1221
Brugia malayi RNase H family protein 0.0719 0.2622 1
Echinococcus granulosus RNA directed DNA polymerase 0.0061 0.0167 0.0618
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0018 0.1221
Echinococcus multilocularis geminin 0.0191 0.0652 0.1933
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0104 0.0099
Loa Loa (eye worm) hypothetical protein 0.0056 0.0149 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0061 0.0167 0.0618
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0061 0.0167 0.0483
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0018 0.0013
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0018 0.0013
Echinococcus multilocularis lamin dm0 0.003 0.0053 0.0141
Trypanosoma brucei unspecified product 0.078 0.285 0.2728
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0061 0.0167 0.0483
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0006 0.0021
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0018 0.0013
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0061 0.0167 0.0483
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0167 0.0162
Trypanosoma brucei RNA helicase, putative 0.2698 1 1
Brugia malayi hypothetical protein 0.0061 0.0167 0.0638
Brugia malayi Zinc knuckle family protein 0.0061 0.0167 0.0638
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0061 0.0167 0.0483
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.1221
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0149 0.0568
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0061 0.0167 0.0618
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0018 0.0048
Schistosoma mansoni intermediate filament proteins 0.003 0.0053 0.0047
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.078 0.285 0.2728
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.1221
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Trypanosoma brucei ingi protein (ORF1) 0.078 0.285 0.2728
Brugia malayi RNase H family protein 0.0719 0.2622 1
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0053 0.0201
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.1221
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0018 0.0038
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0018 0.0038
Giardia lamblia Ribonuclease H 0.0719 0.2622 1
Brugia malayi Zinc knuckle family protein 0.0061 0.0167 0.0638
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0018 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0104 0.0376
Echinococcus granulosus intermediate filament protein 0.003 0.0053 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0018 0.1221
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0018 0.0069
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0006 0.0375
Loa Loa (eye worm) hypothetical protein 0.003 0.0051 0.3397
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0018 0.1221
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0018 0.0069
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0018 0.0069
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0006 0.0021
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0061 0.0167 0.0483
Brugia malayi Pao retrotransposon peptidase family protein 0.0061 0.0167 0.0638
Mycobacterium tuberculosis Possible maturase 0.0061 0.0167 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0104 0.6994
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0104 0.0295
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0914 0.3348 1
Brugia malayi reverse transcriptase 0.0061 0.0167 0.0638
Onchocerca volvulus 0.0061 0.0167 0.0572
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0061 0.0167 0.0483
Brugia malayi hypothetical protein 0.0061 0.0167 0.0638
Trichomonas vaginalis ribonuclease H1, putative 0.0719 0.2622 1
Echinococcus granulosus ribonuclease H1 0.0719 0.2622 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0018 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0104 0.0295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0018 0.1221
Schistosoma mansoni hypothetical protein 0.0061 0.0167 0.0162
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0018 0.0013
Trypanosoma brucei ingi protein (ORF1) 0.078 0.285 0.2728
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0018 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0018 0.1221
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0061 0.0167 0.0162
Echinococcus granulosus KRAB A domain containing protein 0.0061 0.0167 0.0618
Echinococcus multilocularis musashi 0.003 0.0053 0.0141
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0061 0.0167 0.0483
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.1221

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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