Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | 5-hydroxytryptamine (serotonin) receptor 2A | References | |
Mus musculus | dopamine receptor D2 | Starlite/ChEMBL | References |
Mus musculus | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Mus musculus | 5-hydroxytryptamine (serotonin) receptor 2C | References | |
Mus musculus | 5-hydroxytryptamine (serotonin) receptor 2B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0697 | 0.392 | 1 | |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0342 | 0.0885 | 0.0885 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.1761 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.1761 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0709 | 0.403 | 0.403 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0342 | 0.0885 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.1064 | 0.7065 | 0.7065 |
Echinococcus granulosus | hypothetical protein | 0.0845 | 0.519 | 0.519 |
Loa Loa (eye worm) | hypothetical protein | 0.1064 | 0.7065 | 0.7065 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0709 | 0.403 | 0.403 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.1039 | 0.6855 | 0.6855 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0342 | 0.0885 | 0.0885 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0709 | 0.403 | 0.403 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.5092 | 0.5092 |
Brugia malayi | peptidase family M13 containing protein | 0.0342 | 0.0885 | 0.0885 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.1095 | 0.1095 |
Toxoplasma gondii | peptidase family M13 protein | 0.1406 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1064 | 0.7065 | 0.7065 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.1095 | 0.1095 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.1095 | 0.1095 |
Loa Loa (eye worm) | hypothetical protein | 0.1406 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1039 | 0.6855 | 0.6855 |
Loa Loa (eye worm) | hypothetical protein | 0.1064 | 0.7065 | 0.7065 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0342 | 0.0885 | 0.0885 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.1406 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0367 | 0.1095 | 0.1095 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.1039 | 0.6855 | 0.6855 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0239 | 0 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.1761 | 0.1761 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.1406 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1039 | 0.6855 | 0.6855 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.1406 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.1095 | 0.1095 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0709 | 0.403 | 0.403 |
Mycobacterium ulcerans | zinc metalloprotease | 0.1406 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0697 | 0.392 | 0.392 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0709 | 0.403 | 0.403 |
Mycobacterium leprae | probable zinc metalloprotease | 0.1406 | 1 | 0.5 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0342 | 0.0885 | 0.0885 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.1095 | 0.1095 |
Loa Loa (eye worm) | hypothetical protein | 0.1406 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0342 | 0.0885 | 0.0885 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1406 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0567 | 0.281 | 0.281 |
Loa Loa (eye worm) | hypothetical protein | 0.1039 | 0.6855 | 0.6855 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.1761 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1406 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1064 | 0.7065 | 0.7065 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0342 | 0.0885 | 0.0885 |
Schistosoma mansoni | neprilysin | 0.0367 | 0.1095 | 0.1095 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.1761 | 0.1761 |
Loa Loa (eye worm) | hypothetical protein | 0.1064 | 0.7065 | 0.7065 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 0.1095 | 0.1095 |
Loa Loa (eye worm) | hypothetical protein | 0.1039 | 0.6855 | 0.6855 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.1406 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 26.2 mg kg-1 | Oral potency tested by using anti-mescaline test | ChEMBL. | 1360026 |
IC50 (binding) | = 5684 nM | In vitro binding affinity towards dopamine receptor D2 | ChEMBL. | 1360026 |
Ki (binding) | = 10 nM | In vitro binding affinity for the mouse sigma opioid receptor | ChEMBL. | 1360026 |
Ki (binding) | = 3356 nM | In vitro binding affinity for serotonin 5-hydroxytryptamine (5-HT) 2 receptors | ChEMBL. | 1360026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.