Detailed view for Smp_157440

Basic information

TDR Targets ID: 294144
Schistosoma mansoni, family M13 unassigned peptidase (M13 family)
Source Database / ID:  GeneDB

pI: 8.1165 | Length (AA): 515 | MW (Da): 58946 | Paralog Number: 9

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01431   Peptidase family M13
PF05649   Peptidase family M13

Gene Ontology

Mouse over links to read term descriptions.
GO:0004222   metalloendopeptidase activity  
GO:0008237   metallopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 515 3zuk (A) 191 662 18.00 0 0.95 1.03267 0.71
91 515 3dwb (A) 310 770 24.00 0 1 1.00734 0.49
307 515 6gid (A) 540 749 34.00 0 1 0.637625 0.21
311 515 6gid (A) 544 749 28.00 0.000000063 1 0.742658 -0.11

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_137112)

Species Accession Gene Product
Caenorhabditis elegans CELE_ZK20.6   Protein NEP-1
Schistosoma japonicum Sjp_0030770   Neprilysin-1, putative
Schistosoma japonicum Sjp_0079080   Endothelin-converting enzyme 1, putative
Schistosoma japonicum Sjp_0030750   IPR000718,Peptidase M13, neprilysin,domain-containing
Schistosoma japonicum Sjp_0039370   Neprilysin, putative
Schistosoma japonicum Sjp_0203330   Endothelin-converting enzyme-like 1, putative
Schistosoma japonicum Sjp_0030730   expressed protein
Schistosoma japonicum Sjp_0059900   Neprilysin-1, putative
Schistosoma japonicum Sjp_0084660   expressed protein
Schistosoma japonicum Sjp_0094970   expressed protein
Schistosoma japonicum Sjp_0100950   IPR000718,Peptidase M13, neprilysin,domain-containing
Schistosoma japonicum Sjp_0208230   Endothelin-converting enzyme 2, putative
Schistosoma japonicum Sjp_0095430   expressed protein
Schistosoma japonicum Sjp_0099570   IPR000718,Peptidase M13, neprilysin,domain-containing
Schistosoma japonicum Sjp_0103880   Endothelin-converting enzyme 2, putative
Schistosoma mansoni Smp_157440   family M13 unassigned peptidase (M13 family)
Schistosoma mansoni Smp_170480   family M13 unassigned peptidase (M13 family)
Schistosoma mansoni Smp_189930   hypothetical protein
Schistosoma mansoni Smp_194190   Nep2 peptidase (M13 family)
Schistosoma mansoni Smp_170500   family M13 unassigned peptidase (M13 family)
Schistosoma mansoni Smp_170470   hypothetical protein
Schistosoma mansoni Smp_170460   hypothetical protein
Schistosoma mansoni Smp_170490   hypothetical protein
Schistosoma mansoni Smp_191120   hypothetical protein
Schistosoma mansoni Smp_173370   family M13 unassigned peptidase (M13 family)

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.076 0.345 0.345
0.0599 0.4671 0.345
0.0111 0.2865 0.2865
0.0149 0.458 0.458
0.0272 0.493 0.4959
0.1209 0.4074 0.5023
0.0154 0.3741 0.4381
0.0574 0.4962 0.4962
0.0344 0.4422 0.4855
0.0992 0.5029 0.5029
0.1697 0.2879 0.501
0.0096 0.292 0.4541
0.0333 0.3891 0.3891
0.0093 0.3051 0.4673
0.1387 0.5017 0.5017
0.0534 0.2777 0.345
0.0058 0.268 0.268
0.0951 0.3296 0.3296
0.0195 0.2564 0.2564
0.1241 0.5015 0.5015
0.1623 0.3187 0.4618
0.0642 0.4966 0.4965
0.1403 0.4936 0.4931
0.0926 0.3296 0.3296
0.0251 0.2977 0.5003
0.0058 0.4304 0.4299
0.0377 0.3646 0.4989
0.0292 0.385 0.384
0.0058 0.345 0.345
0.0095 0.3248 0.4187
0.014 0.273 0.4234
0.1529 0.2993 0.4628
0.0445 0.345 0.345
0.136 0.4964 0.4964
0.0058 0.3296 0.3296
0.0099 0.4188 0.4188
0.0058 0.4836 0.4836
0.0094 0.3158 0.3908
0.0207 0.2765 0.2765
0.0326 0.3296 0.3296
0.0589 0.4499 0.4888
0.0264 0.3296 0.3296
0.0438 0.4967 0.4967
0.0546 0.4065 0.4996
0.0143 0.4737 0.4737
0.0779 0.5028 0.5028
0.0327 0.2726 0.4909
0.0424 0.4036 0.4036
0.0359 0.2508 0.2508
0.0709 0.403 0.403
0.0292 0.385 0.384
0.0479 0.2997 0.3722
0.1159 0.5014 0.501
0.0304 0.3296 0.3296
0.0262 0.4419 0.4419
0.0158 0.4705 0.4657
0.0919 0.299 0.299
0.0244 0.3679 0.3679
0.0047 0.3288 0.3288
0.0783 0.2845 0.4978
0.0048 0.2721 0.2721
0.0357 0.3617 0.3617
0.0255 0.3296 0.3296
0.0058 0.345 0.345
0.0366 0.4968 0.4968
0.0143 0.2748 0.2618
0.0342 0.4663 0.4663
0.0364 0.4772 0.4772
0.0355 0.345 0.345
0.0553 0.4254 0.4254
0.0581 0.4347 0.4323
0.0058 0.3296 0.3296
0.0294 0.388 0.3878
0.0186 0.4645 0.4775
0.0536 0.4985 0.4979
0.1071 0.4669 0.4669
0.0793 0.3362 0.3296
0.0208 0.4942 0.4942
0.0614 0.4708 0.345
0.0266 0.4639 0.4587
0.1095 0.2665 0.4886
0.0315 0.3296 0.3296
0.0156 0.3296 0.3296
0.0273 0.345 0.345
0.0115 0.4075 0.3759
0.01 0.3072 0.3072
0.0098 0.4046 0.345
0.023 0.397 0.4565
0.1408 0.5005 0.4843
0.0314 0.44 0.4362
0.0201 0.2634 0.2634
0.0146 0.4094 0.4094
0.1039 0.3354 0.3296
0.0706 0.433 0.5032
0.0371887 0.363351 0.363351
0.0151 0.348 0.3714
0.0149 0.306 0.3226
0.0438 0.3602 0.345
0.0121 0.4834 0.4834
0.0591 0.5015 0.501
0.0316 0.4612 0.4612
0.0047 0.2693 0.2693
0.1275 0.4443 0.345
0.1387 0.5017 0.5017
0.042 0.345 0.345
0.0387 0.2588 0.4429
0.0102 0.345 0.345
0.0578 0.3461 0.345
0.0251 0.2977 0.5003
0.0484 0.4772 0.4634
0.046 0.5024 0.502
0.0058 0.345 0.345
0.0553 0.4254 0.4254
0.0058 0.2562 0.2763
0.0256 0.345 0.345
0.0244 0.491 0.491
0.1408 0.5005 0.4843
0.0095 0.345 0.345
0.0197 0.4758 0.4622
0.0155 0.365 0.365
0.0158 0.345 0.345
0.0314 0.3296 0.3296
0.0491 0.4914 0.4914
0.0247 0.3296 0.3296
0.0799 0.4985 0.4985
0.0099 0.4296 0.345
0.0146 0.4386 0.4386
0.0098 0.29 0.29
0.1281 0.4986 0.4983
0.0591 0.5015 0.501
0.023 0.397 0.4565
0.0101 0.345 0.345
0.0824 0.5034 0.5034
0.0109 0.322 0
0.0567 0.4675 0.4779
0.0292 0.385 0.384
0.0164 0.4558 0.4558
0.0793 0.3069 0.3535
0.0355 0.3001 0.3001
0.0093 0.345 0.345
0.02 0.4161 0.4824
0.1209 0.4074 0.5023
0.0347 0.4883 0.4883
0.0058 0.2562 0.2763
0.0706 0.433 0.5032
0.1619 0.4961 0.4915
0.0383 0.294 0.2937
0.0299 0.4831 0.4831
0.0213 0.27 0.4196
0.0919 0.299 0.299
0.0115 0.4819 0.4819
0.02 0.4772 0.4725
0.026 0.3909 0.345
0.0352 0.3296 0.3296
0.0106 0.4359 0.4359
0.0544 0.4804 0.4682
0.1777 0.3715 0.345
0.1075 0.4876 0.4876
0.0484 0.4773 0.4757
0.0217 0.4851 0.4851
0.0609 0.3267 0.3267
0.0255 0.468 0.468
0.0594 0.3342 0.3568
0.0589 0.4499 0.4888
0.0175 0.3296 0.3296
0.0162 0.4687 0.4687
0.0217 0.4823 0.4823
0.0367 0.4562 0.4939
0.1239 0.4468 0.345
0.0157 0.3903 0.3903
0.0642 0.4966 0.4965
0.0329 0.2734 0.4909
0.0184 0.2978 0.4256
0.0299 0.4896 0.4758
0.0162 0.4687 0.4687
0.0528 0.345 0.345
0.0372 0.4631 0.4631
0.0364 0.4772 0.4772
0.0108 0.345 0.345
0.0314 0.3296 0.3296
0.1387 0.5017 0.5017
0.0536 0.4985 0.4979
0.1244 0.3973 0.3973
0.0093 0.2553 0.2493
0.0384 0.4627 0.345
0.0455 0.4957 0.4957
0.0597 0.4481 0.4481
0.148 0.345 0.345
0.0391 0.3868 0.4768
0.015 0.469 0.4605
0.1452 0.345 0.345
0.0793 0.3069 0.3535
0.0058 0.3296 0.3296
0.0555 0.256 0.4453
0.1209 0.4074 0.5023
0.0189 0.4907 0.4907
0.0653 0.3757 0.3757
0.024 0.341 0.341
0.0237 0.3027 0.3027
0.0326 0.3296 0.3296
0.1403 0.4936 0.4931
0.0866 0.4855 0.4471
0.0106 0.3519 0.4741
0.0048 0.2861 0.2861
0.0095 0.345 0.345
0.0161 0.4776 0.4687
0.1689 0.2653 0.2653
0.0996 0.4741 0.4741
0.0504 0.4219 0.4219
0.0101 0.3012 0
0.0364 0.4772 0.4772
0.0162 0.4687 0.4687
0.024 0.341 0.341
0.0566 0.4965 0.4965
0.0411 0.3261 0.3255
0.0115 0.3296 0.3296
0.0058 0.4823 0.4823
0.1431 0.4753 0.4609
0.0372 0.4631 0.4631
0.0272 0.4196 0.4196
0.0144 0.3296 0.3296
0.0058 0.4836 0.4836
0.0056 0.3296 0.3296
0.0337 0.4517 0.4517
0.0411 0.345 0.345
0.3049 0.2973 0.5032
0.0803 0.4685 0.4685
0.0242 0.4788 0.4788
0.0314 0.44 0.4362
0.0584 0.2732 0.4113
0.0264 0.3296 0.3296
0.0508 0.4534 0.492
0.0111 0.3296 0.3296
0.0115 0.3296 0.3296
0.0189 0.4272 0.4688
0.0566 0.4965 0.4965
0.0139 0.2721 0.4454
0.0358 0.4308 0.345
0.02 0.2834 0.2834
0.015 0.345 0.345
0.0589 0.305 0.4646
0.0527 0.2558 0.4651
0.0678 0.4505 0.4646
0.0058 0.3296 0.3296
0.0709 0.403 0.403
0.0367 0.4562 0.4939
0.0451 0.4983 0.4983
0.005 0.4868 0.4868
0.0144 0.3296 0.3296
0.0099 0.4296 0.345
0.02 0.2834 0.2834
0.0338 0.4676 0.4676
0.1689 0.2653 0.2653
0.0102 0.4262 0.409
0.0301 0.4335 0.4335
0.0346 0.4956 0.4956
0.0793 0.3069 0.3535
0.0058 0.345 0.345
0.0111 0.3296 0.3296
0.0201 0.2634 0.2634
0.113 0.5033 0.5033
0.0533 0.3118 0.3118
0.0058 0.3962 0.3962
0.0793 0.3069 0.3535
0.0574 0.4962 0.4962
0.0235 0.3022 0.3296
0.0109 0.3135 0.3118
0.0575 0.4903 0.345
0.0106 0.3156 0
0.0372 0.4631 0.4631
0.0251 0.2977 0.5003
0.0411 0.3261 0.3255
0.0349 0.4986 0.4986
0.0094 0.3296 0.3296
0.111 0.4489 0.4489
0.0099 0.4296 0.345
0.0047 0.2693 0.2693
0.047 0.345 0.345
0.0207 0.2765 0.2765
0.0058 0.4172 0.4172
0.0094 0.2529 0.37
0.0058 0.3296 0.3296
0.131 0.2516 0.4755
0.0591 0.5015 0.501
0.0115 0.399 0.399
0.0205 0.2714 0.345
0.027 0.2842 0.4919
0.0115 0.3921 0.3921
0.0303 0.4957 0.4742
0.0978 0.345 0.345
0.0232 0.318 0.4935
0.0793 0.3069 0.3535
0.0144 0.3296 0.3296
0.0688 0.4682 0.4682
0.0388 0.463 0.4738
0.0115 0.3886 0.3612
0.0058 0.345 0.345
0.0095 0.2697 0.2676
0.0115 0.345 0.345
0.0377 0.302 0.4917
0.0327 0.497 0.4969
0.0498 0.3015 0.3015
0.0217 0.4389 0.4019
0.0334 0.3296 0.3296
0.1307 0.504 0.504
0.0245 0.4423 0.4423
0.0115 0.3681 0.3681
0.1075 0.4876 0.4876
0.0115 0.3251 0
0.047 0.4924 0.4924
0.0694 0.5015 0.5015
0.0736 0.3296 0.3296
0.0579 0.468 0.345
0.031 0.345 0.345
0.0228 0.4568 0.4568
0.0105 0.345 0.345
0.0255 0.468 0.468
0.0455 0.4957 0.4957
0.0458 0.4991 0.4983
0.0115 0.3251 0
0.0651 0.345 0.345
0.0109 0.4568 0.4568
0.0656 0.4826 0.4826
0.0546 0.4065 0.4996
0.0292 0.385 0.384
0.0121 0.4834 0.4834
0.1689 0.2653 0.2653
0.1403 0.4936 0.4931
0.0297 0.3368 0.4938
0.1429 0.4754 0.4611
0.0392 0.2818 0.3053
0.0162 0.4687 0.4687
0.067 0.3644 0.345
0.0245 0.2715 0.4215
0.0411 0.3261 0.3255
0.0143 0.396 0.345
0.143 0.5029 0.5029
0.0139 0.2721 0.4454
0.0211 0.3499 0.3499
0.1091 0.3251 0.4759
0.0102 0.4636 0.4262
0.1209 0.4074 0.5023
0.0115 0.345 0.345
0.0927 0.3677 0.3677
0.1209 0.4703 0.4533
0.0106 0.3519 0.4741
0.0408 0.345 0.345
0.0573 0.316 0.345

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_157440 (Schistosoma mansoni), family M13 unassigned peptidase (M13 family)
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