Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Sigma-1 receptor | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Abnormal catecholamine distribution protein 1 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | 532 aa | 504 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0047 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0047 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.5028 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0047 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0047 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0047 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.286 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.286 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.286 | 0.2826 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.5028 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.5028 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.286 | 0.5647 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.286 | 0.5647 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.5028 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0047 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.286 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.5028 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.2375 | 0.4674 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 107 nM | Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 A123.7 cells after 20 hrs | ChEMBL. | 21732626 |
Ki (binding) | = 2225 nM | Displacement of (+)-[3H]pentazocine from sigma 1 receptor in guinea pig brain membrane homogenates after 90 mins by liquid scintillation counting | ChEMBL. | 21732626 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.