Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0027 | 0.0266 | 0.0667 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0081 | 0.1512 | 0.3786 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.0933 | 0.1697 |
Brugia malayi | TAR-binding protein | 0.007 | 0.1246 | 0.2265 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0081 | 0.1512 | 0.3786 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.1512 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0243 | 0.0442 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.045 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0266 | 0.0484 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.045 | 1 | 0.5 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0081 | 0.1512 | 0.3786 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.1246 | 0.2265 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.0933 | 0.1697 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0111 | 0.0202 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0111 | 0.0202 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0255 | 0.5499 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0111 | 0.0278 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.002 | 0.0111 | 0.0278 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0172 | 0.3596 | 1 |
Onchocerca volvulus | 0.0056 | 0.0933 | 1 | |
Mycobacterium ulcerans | peptide deformylase | 0.045 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.045 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.045 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.002 | 0.0111 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0111 | 0.0202 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.002 | 0.0111 | 0.0278 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.002 | 0.0111 | 0.0278 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0081 | 0.1512 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0933 | 0.1697 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.002 | 0.0111 | 0.0202 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0081 | 0.1512 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0255 | 0.5499 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.002 | 0.0111 | 0.0278 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0172 | 0.3596 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0172 | 0.3596 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.002 | 0.0111 | 0.0202 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.002 | 0.0111 | 0.0278 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.1246 | 0.312 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0674 | 0.1689 |
Plasmodium falciparum | peptide deformylase | 0.045 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0111 | 0.0278 |
Onchocerca volvulus | 0.0056 | 0.0933 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.002 | 0.0111 | 0.0202 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1246 | 0.312 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0172 | 0.3596 | 1 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0081 | 0.1512 | 0.2749 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0768 | 0.1397 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1246 | 0.312 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.0933 | 0.1697 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0172 | 0.3596 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.002 | 0.0111 | 0.0278 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.1246 | 0.2265 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0081 | 0.1512 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.1246 | 0.2265 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0768 | 0.1397 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.091 | 0.1654 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0111 | 0.0278 |
Echinococcus multilocularis | musashi | 0.0056 | 0.0933 | 0.2337 |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 0.0933 | 0.2337 |
Schistosoma mansoni | lamin | 0.0056 | 0.0933 | 0.2337 |
Plasmodium vivax | peptide deformylase, putative | 0.045 | 1 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.002 | 0.0111 | 0.0278 |
Schistosoma mansoni | coup transcription factor | 0.002 | 0.0111 | 0.0278 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.002 | 0.0111 | 0.0278 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.002 | 0.0111 | 0.0278 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.002 | 0.0111 | 0.0202 |
Brugia malayi | ecdysteroid receptor | 0.002 | 0.0111 | 0.0202 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0081 | 0.1512 | 0.3786 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.002 | 0.0111 | 0.0278 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0674 | 0.1689 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0768 | 0.1397 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0111 | 0.0278 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.1246 | 0.2265 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0674 | 0.1689 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.002 | 0.0111 | 0.0202 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0111 | 0.0278 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.0335 | 0.0609 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0081 | 0.1512 | 0.3786 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.002 | 0.0111 | 0.0278 |
Schistosoma mansoni | thyroid hormone receptor | 0.002 | 0.0111 | 0.0278 |
Echinococcus granulosus | FTZ F1 alpha | 0.002 | 0.0111 | 0.0278 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0768 | 0.1397 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.002 | 0.0111 | 0.0202 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0111 | 0.0278 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0674 | 0.1226 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0111 | 0.0202 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.1246 | 0.312 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.002 | 0.0111 | 0.0278 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0172 | 0.3596 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.002 | 0.0111 | 0.0202 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 0.0933 | 0.2337 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0081 | 0.1512 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.002 | 0.0111 | 0.0202 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.002 | 0.0111 | 0.0202 |
Echinococcus granulosus | lamin | 0.0056 | 0.0933 | 0.2337 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0674 | 0.1689 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.002 | 0.0111 | 0.0278 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.002 | 0.0111 | 0.0278 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0413 | 0.075 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0081 | 0.1512 | 0.3786 |
Schistosoma mansoni | nuclear hormone receptor | 0.002 | 0.0111 | 0.0278 |
Brugia malayi | RNA binding protein | 0.007 | 0.1246 | 0.2265 |
Schistosoma mansoni | lamin | 0.0056 | 0.0933 | 0.2337 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0674 | 0.1689 |
Toxoplasma gondii | hypothetical protein | 0.045 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.002 | 0.0111 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0111 | 0.0202 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0172 | 0.3596 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.002 | 0.0111 | 0.0202 |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 0.0933 | 0.2337 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0111 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0111 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0413 | 0.075 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.002 | 0.0111 | 0.0278 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1246 | 0.312 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0674 | 0.1689 |
Brugia malayi | nuclear hormone receptor | 0.002 | 0.0111 | 0.0202 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1246 | 0.312 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.002 | 0.0111 | 0.0278 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.002 | 0.0111 | 0.0202 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.002 | 0.0111 | 0.0278 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.002 | 0.0111 | 0.0202 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0674 | 0.1689 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0111 | 0.0202 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0081 | 0.1512 | 0.3786 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0027 | 0.0266 | 0.0667 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 0.0933 | 0.2337 |
Brugia malayi | nuclear receptor NHR-88 | 0.002 | 0.0111 | 0.0202 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.002 | 0.0111 | 0.0202 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.002 | 0.0111 | 0.0202 |
Echinococcus multilocularis | FTZ F1 alpha | 0.002 | 0.0111 | 0.0278 |
Echinococcus granulosus | geminin | 0.0189 | 0.3992 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.002 | 0.0111 | 0.0278 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.002 | 0.0111 | 0.0278 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.3992 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0111 | 0.0202 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.1246 | 0.312 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.003 | 0.0335 | 0.0609 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.002 | 0.0111 | 0.0202 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.3992 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0111 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0243 | 0.0442 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0413 | 0.1034 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.0933 | 0.1697 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0081 | 0.1512 | 0.3786 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.002 | 0.0111 | 0.0202 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.002 | 0.0111 | 0.0278 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.002 | 0.0111 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1512 | 0.2749 |
Echinococcus multilocularis | geminin | 0.0189 | 0.3992 | 1 |
Brugia malayi | steroid hormone receptor | 0.002 | 0.0111 | 0.0202 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0674 | 0.1226 |
Echinococcus multilocularis | lamin | 0.0056 | 0.0933 | 0.2337 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0111 | 0.0202 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.002 | 0.0111 | 0.0202 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.002 | 0.0111 | 0.0202 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.