Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | Starlite/ChEMBL | References |
Cavia porcellus | Sigma-1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Abnormal catecholamine distribution protein 1 | solute carrier family 18 (vesicular acetylcholine transporter), member 3 | 532 aa | 504 aa | 34.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0161 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0161 | 0.0139 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.585 | 0.5782 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0022 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0161 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0022 | 0.139 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0267 | 0.585 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0161 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0267 | 0.585 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.4922 | 0.4911 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0161 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0161 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0161 | 0.0139 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0161 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0161 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0161 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0161 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0267 | 0.585 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0161 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0161 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0267 | 0.585 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0022 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0267 | 0.585 | 0.584 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0022 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0161 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0161 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0161 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0161 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0161 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3144 nM | Displacement of (+)-[3H]pentazocine from sigma 1 receptor in guinea pig brain membrane homogenates after 90 mins by liquid scintillation counting | ChEMBL. | 21732626 |
Ki (binding) | = 3600 nM | Displacement of (-)-[3H]vesamicol from human VAChT expressed in rat PC12 A123.7 cells after 20 hrs | ChEMBL. | 21732626 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.