Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | renin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | aspartyl proteinase, putative | 0.0059 | 0.2146 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0059 | 0.2146 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0059 | 0.2146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2146 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0026 | 0.0365 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.8562 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0059 | 0.2146 | 0.2506 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.8417 | 0.9832 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0059 | 0.2146 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0203 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0 | 0.5 |
Giardia lamblia | Kinesin-5 | 0.0026 | 0.0365 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0026 | 0.0365 | 0.0427 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1537 | 0.7163 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 0.8417 | 0.9832 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1537 | 0.1795 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1537 | 0.1795 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1537 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0059 | 0.2146 | 0.2146 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1537 | 0.1537 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0059 | 0.2146 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1537 | 0.1537 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0026 | 0.0365 | 0.1703 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0059 | 0.2146 | 0.2146 |
Plasmodium falciparum | plasmepsin I | 0.0059 | 0.2146 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1537 | 0.1795 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0 | 0.5 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0026 | 0.0365 | 0.1703 |
Plasmodium vivax | kinesin-5 | 0.0026 | 0.0365 | 0.1703 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0059 | 0.2146 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0026 | 0.0365 | 0.1703 |
Brugia malayi | Kinesin motor domain containing protein | 0.0026 | 0.0365 | 0.2377 |
Plasmodium falciparum | plasmepsin VI | 0.0059 | 0.2146 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0059 | 0.2146 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1537 | 0.1537 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1537 | 0.1537 |
Plasmodium falciparum | plasmepsin II | 0.0059 | 0.2146 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.011 uM | Inhibition of recombinant human renin using Dabcyl-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 2 hrs by spectrofluorometry | ChEMBL. | 21840215 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.