Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | smoothened, frizzled class receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | smoothened | Get druggable targets OG5_134998 | All targets in OG5_134998 |
Echinococcus multilocularis | smoothened | Get druggable targets OG5_134998 | All targets in OG5_134998 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134998 | All targets in OG5_134998 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.077 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0.077 | 0.5 |
Echinococcus multilocularis | protein kinase shaggy | 0.0058 | 0.077 | 0.077 |
Onchocerca volvulus | 0.0534 | 1 | 1 | |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.077 | 0.077 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0534 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 0.7438 | 0.7438 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.077 | 0.5 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0058 | 0.077 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0534 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0534 | 1 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0058 | 0.077 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0534 | 1 | 1 |
Giardia lamblia | Kinase, CDC7 | 0.0534 | 1 | 1 |
Echinococcus granulosus | protein kinase shaggy | 0.0058 | 0.077 | 0.077 |
Brugia malayi | intracellular kinase | 0.0058 | 0.077 | 0.077 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0058 | 0.077 | 0.5 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0058 | 0.077 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0534 | 1 | 1 |
Echinococcus multilocularis | smoothened | 0.041 | 0.7602 | 0.7602 |
Onchocerca volvulus | 0.0534 | 1 | 1 | |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0.077 | 0.5 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0058 | 0.077 | 0.077 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.077 | 0.077 |
Echinococcus granulosus | smoothened | 0.041 | 0.7602 | 0.7602 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0058 | 0.077 | 0.5 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0534 | 1 | 1 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0058 | 0.077 | 0.077 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0534 | 1 | 1 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0058 | 0.077 | 0.077 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 44 nM | Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assay | ChEMBL. | 21840217 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.