Detailed information for compound 104422

Basic information

Technical information
  • TDR Targets ID: 104422
  • Name: 2-(2,3-dihydro-1H-inden-2-yl)-1-[(2R)-2-(pyrr olidine-1-carbonyl)pyrrolidin-1-yl]ethanone
  • MW: 326.433 | Formula: C20H26N2O2
  • H donors: 0 H acceptors: 2 LogP: 2.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC[C@@H]1C(=O)N1CCCC1)CC1Cc2c(C1)cccc2
  • InChi: 1S/C20H26N2O2/c23-19(14-15-12-16-6-1-2-7-17(16)13-15)22-11-5-8-18(22)20(24)21-9-3-4-10-21/h1-2,6-7,15,18H,3-5,8-14H2/t18-/m1/s1
  • InChiKey: SUPHKXCIZNFXDF-GOSISDBHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-indan-2-yl-1-[(2R)-2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl]ethanone
  • 2-(2-indanyl)-1-[(2R)-2-[oxo(1-pyrrolidinyl)methyl]-1-pyrrolidinyl]ethanone
  • 2-(2,3-dihydro-1H-inden-2-yl)-1-[(2R)-2-pyrrolidin-1-ylcarbonylpyrrolidin-1-yl]ethanone
  • 2-indan-2-yl-1-[(2R)-2-(pyrrolidine-1-carbonyl)pyrrolidino]ethanone
  • 2-(2-indanyl)-1-[(2R)-2-(oxo-1-pyrrolidinylmethyl)-1-pyrrolidinyl]ethanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prolyl endopeptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_129295 All targets in OG5_129295
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus granulosus prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Neospora caninum Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
Toxoplasma gondii prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum Prolyl endopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania mexicana prolyl oligopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania infantum prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania donovani prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Onchocerca volvulus Prolyl endopeptidase homolog Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma congolense prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma cruzi prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus multilocularis prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei gambiense prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei oligopeptidase b prolyl endopeptidase 710 aa 630 aa 27.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Trypsin family protein 0.0138 0.0525 0.1137
Loa Loa (eye worm) PAN domain-containing protein 0.0153 0.0616 0.1334
Loa Loa (eye worm) TK/ROR protein kinase 0.0182 0.0784 0.1702
Toxoplasma gondii PAN domain-containing protein 0.0153 0.0616 0.0618
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0065 0.0106 0.0347
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0138 0.0525 0.1775
Brugia malayi excitatory GABA receptor EXP-1A 0.0065 0.0106 0.0222
Onchocerca volvulus 0.0138 0.0525 0.0936
Onchocerca volvulus 0.0153 0.0616 0.1138
Loa Loa (eye worm) hypothetical protein 0.0176 0.0747 0.1622
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0204 0.091 0.0907
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0301 0.1011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0106 0.0222
Schistosoma mansoni pyruvate dehydrogenase 0.0109 0.0359 0.0356
Onchocerca volvulus 0.0176 0.0747 0.1432
Trypanosoma brucei developmentally regulated phosphoprotein 0.0115 0.0396 0.5504
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0158 0.0644 0.064
Brugia malayi PAN domain containing protein 0.0153 0.0616 0.1334
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0065 0.0106 0.0222
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0115 0.0396 0.1336
Brugia malayi PAN domain containing protein 0.0153 0.0616 0.1334
Loa Loa (eye worm) hypothetical protein 0.0153 0.0616 0.1334
Loa Loa (eye worm) hypothetical protein 0.0138 0.0525 0.1137
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0065 0.0106 0.0222
Loa Loa (eye worm) ACC-1 protein 0.0065 0.0106 0.0222
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.009 0.0187
Schistosoma mansoni pyruvate dehydrogenase 0.0115 0.0396 0.0393
Echinococcus granulosus nAChR subunit 0.0065 0.0106 0.0347
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0115 0.0396 0.1336
Loa Loa (eye worm) hypothetical protein 0.0204 0.091 0.1977
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0078 0.0183 0.1296
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0138 0.0525 0.1775
Plasmodium falciparum cysteine repeat modular protein 1 0.0182 0.0784 0.5
Loa Loa (eye worm) calcium channel 0.0115 0.0397 0.0857
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0106 0.0222
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Toxoplasma gondii kringle domain-containing protein 0.0182 0.0784 0.0787
Loa Loa (eye worm) hypothetical protein 0.0153 0.0616 0.1334
Schistosoma mansoni voltage-gated potassium channel 0.0555 0.2941 0.2938
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0106 0.0102
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0065 0.0106 0.0222
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0065 0.0106 0.0222
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0142 0.0548 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0065 0.0106 0.0347
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0106 0.0222
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Toxoplasma gondii PAN domain-containing protein 0.0153 0.0616 0.0618
Onchocerca volvulus 0.0703 0.3792 0.8225
Echinococcus granulosus glycine receptor subunit beta 0.0065 0.0106 0.0347
Onchocerca volvulus 0.0153 0.0616 0.1138
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0115 0.0397 0.1338
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0115 0.0397 0.0857
Toxoplasma gondii PAN domain-containing protein 0.0153 0.0616 0.0618
Onchocerca volvulus 0.0153 0.0616 0.1138
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0078 0.0183 0.1625
Brugia malayi CUB domain containing protein 0.006 0.0077 0.016
Loa Loa (eye worm) hypothetical protein 0.0153 0.0616 0.1334
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0106 0.0222
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0182 0.0784 0.5
Brugia malayi Kringle domain containing protein 0.0182 0.0784 0.1702
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0106 0.0347
Brugia malayi PAN domain containing protein 0.0153 0.0616 0.1334
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0106 0.0347
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0106 0.0222
Echinococcus granulosus glycoprotein Antigen 5 0.0138 0.0525 0.1775
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0065 0.0106 0.0347
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0115 0.0397 0.0393
Brugia malayi Cation transporter family protein 0.0204 0.091 0.1977
Brugia malayi PAN domain containing protein 0.0153 0.0616 0.1334
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0115 0.0397 0.1338
Brugia malayi PAN domain containing protein 0.0153 0.0616 0.1334
Loa Loa (eye worm) hypothetical protein 0.0204 0.091 0.1977
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Brugia malayi Trypsin family protein 0.0138 0.0525 0.1137
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0106 0.0347
Echinococcus multilocularis glycine receptor subunit beta 0.0065 0.0106 0.0347
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0063 0.0093 0.5
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0555 0.2941 0.6408
Loa Loa (eye worm) trypsin family protein 0.0138 0.0525 0.1137
Mycobacterium ulcerans hypothetical protein 0.0138 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0644 0.1396
Leishmania major hypothetical protein, conserved 0.0182 0.0784 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0065 0.0106 0.0222
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0065 0.0106 0.0347
Schistosoma mansoni serine-type protease inhibitor 0.1776 1 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Loa Loa (eye worm) ACC-1 protein 0.0065 0.0106 0.0222
Loa Loa (eye worm) hypothetical protein 0.0138 0.0525 0.1137
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0166 0.0687 0.0684
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0065 0.0106 0.0222
Brugia malayi prolyl oligopeptidase family protein 0.0158 0.0644 0.1396
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0065 0.0106 0.0222
Echinococcus multilocularis glycoprotein Antigen 5 0.0138 0.0525 0.1775
Schistosoma mansoni nAChR subunit 0.0065 0.0106 0.0102
Brugia malayi hypothetical protein 0.0138 0.0525 0.1137
Onchocerca volvulus 0.0204 0.091 0.1795
Brugia malayi Trypsin family protein 0.0138 0.0525 0.1137
Loa Loa (eye worm) hypothetical protein 0.0153 0.0616 0.1334
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0158 0.0644 0.064
Echinococcus granulosus tissue type plasminogen activator 0.0182 0.0784 0.2655
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0065 0.0106 0.0347
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0115 0.0397 0.1338
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0106 0.0222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0138 0.0525 0.0522
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0106 0.0222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0138 0.0525 0.0522
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0065 0.0106 0.0222
Toxoplasma gondii PAN domain-containing protein 0.1769 0.9958 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Loa Loa (eye worm) hypothetical protein 0.084 0.4588 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0106 0.0102
Onchocerca volvulus Prolyl endopeptidase homolog 0.0158 0.0644 0.1201
Echinococcus multilocularis transmembrane protease serine 3 0.0138 0.0525 0.1775
Onchocerca volvulus 0.0138 0.0525 0.0936
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0065 0.0106 0.0102
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0065 0.0106 0.0347
Onchocerca volvulus 0.0204 0.091 0.1795
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0138 0.0525 0.0522
Brugia malayi SEA domain containing protein 0.0176 0.0747 0.1622
Schistosoma mansoni nAChR subunit 0.0065 0.0106 0.0102
Onchocerca volvulus 0.0176 0.0747 0.1432
Loa Loa (eye worm) hypothetical protein 0.0138 0.0525 0.1137
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0065 0.0106 0.0347
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0012 0.0018
Brugia malayi PAN domain containing protein 0.0153 0.0616 0.1334
Trypanosoma brucei prolyl endopeptidase 0.0158 0.0644 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.084 0.4588 0.4586
Loa Loa (eye worm) hypothetical protein 0.0138 0.0525 0.1137
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0115 0.0397 0.0393
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0138 0.0525 0.0522
Loa Loa (eye worm) PAN domain-containing protein 0.0153 0.0616 0.1334
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Brugia malayi kinase, mitochondrial precursor 0.0115 0.0396 0.0856
Echinococcus multilocularis glycine receptor subunit beta 0.0065 0.0106 0.0347
Loa Loa (eye worm) hypothetical protein 0.006 0.0077 0.016
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0065 0.0106 0.0347
Toxoplasma gondii subtilisin SUB12 0.0153 0.0616 0.0618
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0065 0.0106 0.0347
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0065 0.0106 0.0222
Echinococcus multilocularis sodium channel protein 0.0061 0.0082 0.0267
Toxoplasma gondii PAN domain-containing protein 0.0153 0.0616 0.0618
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0115 0.0396 0.1336
Loa Loa (eye worm) hypothetical protein 0.0049 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.084 0.4588 1
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0183 0.018
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Onchocerca volvulus 0.0153 0.0616 0.1138
Loa Loa (eye worm) hypothetical protein 0.0153 0.0616 0.1334
Echinococcus granulosus voltage dependent calcium channel 0.0115 0.0397 0.1338
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Echinococcus granulosus transmembrane protease serine 3 0.0138 0.0525 0.1775
Toxoplasma gondii PAN domain-containing protein 0.1769 0.9958 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0077 0.016
Onchocerca volvulus 0.0138 0.0525 0.0936
Schistosoma mansoni nAChR subunit 0.0065 0.0106 0.0102
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0138 0.0525 0.0522
Echinococcus granulosus prolyl endopeptidase 0.0158 0.0644 0.2179
Schistosoma mansoni hypothetical protein 0.0176 0.0747 0.0744
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0115 0.0397 0.1338
Echinococcus multilocularis voltage dependent calcium channel 0.0115 0.0397 0.1338
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0138 0.0525 0.1137
Schistosoma mansoni voltage-gated potassium channel 0.0555 0.2941 0.2938
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0106 0.0347
Toxoplasma gondii prolyl endopeptidase 0.0158 0.0644 0.0647
Toxoplasma gondii microneme protein MIC17B 0.0153 0.0616 0.0618
Onchocerca volvulus 0.0176 0.0747 0.1432
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Brugia malayi PAN domain containing protein 0.0153 0.0616 0.1334
Echinococcus granulosus potassium voltage gated channel protein 0.0555 0.2941 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0115 0.0397 0.1338
Onchocerca volvulus 0.0176 0.0747 0.1432
Schistosoma mansoni voltage-gated cation channel 0.0115 0.0397 0.0393
Brugia malayi Protein kinase domain containing protein 0.0182 0.0784 0.1702
Onchocerca volvulus 0.0204 0.091 0.1795
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0106 0.0347
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0065 0.0106 0.0222
Loa Loa (eye worm) PAN domain-containing protein 0.0153 0.0616 0.1334
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0115 0.0396 0.4389
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0153 0.0616 0.0618
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0012 0.0018
Echinococcus multilocularis potassium voltage gated channel protein 0.0555 0.2941 1
Onchocerca volvulus 0.0138 0.0525 0.0936
Schistosoma mansoni hypothetical protein 0.0138 0.0525 0.0522
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0138 0.0525 0.1775
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.0115 0.0396 0.0856
Brugia malayi Trypsin family protein 0.084 0.4588 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0065 0.0106 0.0347
Brugia malayi PAN domain containing protein 0.0153 0.0616 0.1334
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Brugia malayi jmjC domain containing protein 0.0099 0.0301 0.0648
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0531 0.2801 0.9524
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0065 0.0106 0.0222
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0106 0.0222
Schistosoma mansoni hypothetical protein 0.0182 0.0784 0.078
Loa Loa (eye worm) hypothetical protein 0.0555 0.2941 0.6408
Brugia malayi Cation transporter family protein 0.0065 0.0106 0.0222
Schistosoma mansoni nAChR subunit 0.0065 0.0106 0.0102
Loa Loa (eye worm) hypothetical protein 0.0182 0.0784 0.1702
Onchocerca volvulus 0.0153 0.0616 0.1138
Brugia malayi Muscle positioning protein 4 0.0176 0.0747 0.1622
Onchocerca volvulus 0.0153 0.0616 0.1138
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0065 0.0106 0.0347
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0065 0.0106 0.0347
Schistosoma mansoni nAChR subunit 0.0065 0.0106 0.0102
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0065 0.0106 0.0347
Onchocerca volvulus 0.0153 0.0616 0.1138
Echinococcus multilocularis enteropeptidase 0.0138 0.0525 0.1775
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0115 0.0397 0.1338
Toxoplasma gondii microneme protein MIC17A 0.0153 0.0616 0.0618
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Toxoplasma gondii hypothetical protein 0.0153 0.0616 0.0618
Trypanosoma cruzi hypothetical protein, conserved 0.0182 0.0784 1
Onchocerca volvulus 0.0153 0.0616 0.1138
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0065 0.0106 0.0347
Toxoplasma gondii microneme protein MIC4 0.0153 0.0616 0.0618
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0138 0.0525 0.1775
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0065 0.0106 0.0222
Loa Loa (eye worm) hypothetical protein 0.0176 0.0747 0.1622
Loa Loa (eye worm) hypothetical protein 0.0179 0.0763 0.1656
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0115 0.0397 0.1338
Loa Loa (eye worm) LGC-31 protein 0.0065 0.0106 0.0222
Loa Loa (eye worm) hypothetical protein 0.0138 0.0525 0.1137
Loa Loa (eye worm) PAN domain-containing protein 0.0153 0.0616 0.1334
Echinococcus granulosus glycine receptor subunit beta 0.0065 0.0106 0.0347
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0158 0.0644 0.7975
Loa Loa (eye worm) DOMON domain-containing protein 0.0176 0.0747 0.1622
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Onchocerca volvulus 0.0153 0.0616 0.1138
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Echinococcus multilocularis voltage dependent calcium channel 0.0115 0.0397 0.1338
Echinococcus multilocularis nAChR subunit 0.0065 0.0106 0.0347
Echinococcus multilocularis Mastin 0.0138 0.0525 0.1775
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Schistosoma mansoni nAChR subunit 0.0065 0.0106 0.0102
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0106 0.0347
Toxoplasma gondii PAN/Apple domain-containing protein 0.0153 0.0616 0.0618
Leishmania major developmentally regulated phosphoprotein-like protein 0.0115 0.0396 0.4389
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0012 0.0018
Onchocerca volvulus 0.0153 0.0616 0.1138
Schistosoma mansoni pyruvate dehydrogenase 0.0109 0.0359 0.0356
Trypanosoma cruzi prolyl endopeptidase 0.0158 0.0644 0.7975
Loa Loa (eye worm) hypothetical protein 0.0153 0.0616 0.1334
Schistosoma mansoni nAChR subunit 0.0065 0.0106 0.0102
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.09 0.4935 0.4933
Echinococcus granulosus enteropeptidase 0.0138 0.0525 0.1775
Brugia malayi Cation transporter family protein 0.0065 0.0106 0.0222
Toxoplasma gondii microneme protein, putative 0.0153 0.0616 0.0618
Toxoplasma gondii microneme protein MIC17C 0.0153 0.0616 0.0618
Brugia malayi PAN domain containing protein 0.0153 0.0616 0.1334
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0065 0.0106 0.0347
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0061 0.0082 0.0267
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0065 0.0106 0.0222
Onchocerca volvulus 0.0182 0.0784 0.1513
Toxoplasma gondii hypothetical protein 0.0153 0.0616 0.0618
Echinococcus granulosus Mastin 0.0138 0.0525 0.1775
Loa Loa (eye worm) PAN domain-containing protein 0.0153 0.0616 0.1334
Loa Loa (eye worm) hypothetical protein 0.0052 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0115 0.0397 0.0857
Onchocerca volvulus 0.0138 0.0525 0.0936
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Brugia malayi Trypsin-like protease protein 5 0.0138 0.0525 0.1137
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Loa Loa (eye worm) hypothetical protein 0.0065 0.0106 0.0222
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0301 0.1011
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0555 0.2941 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Echinococcus multilocularis prolyl endopeptidase 0.0158 0.0644 0.2179
Schistosoma mansoni hypothetical protein 0.0138 0.0525 0.0522
Onchocerca volvulus 0.084 0.4588 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0106 0.0222
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0204 0.091 0.0907
Schistosoma mansoni cercarial elastase (S01 family) 0.0138 0.0525 0.0522
Onchocerca volvulus 0.0153 0.0616 0.1138
Echinococcus multilocularis tissue type plasminogen activator 0.0182 0.0784 0.2655
Onchocerca volvulus 0.0176 0.0747 0.1432
Brugia malayi PAN domain containing protein 0.0153 0.0616 0.1334
Loa Loa (eye worm) hypothetical protein 0.0153 0.0616 0.1334

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17 nM In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain. ChEMBL. 8027988
IC50 (binding) = 17 nM In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain. ChEMBL. 8027988

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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