Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin D (A01 family) | 0.0575 | 0.2657 | 1 |
Brugia malayi | Trypsin family protein | 0.0115 | 0.0018 | 0.0018 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.012 | 0.0046 | 0.0104 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0372 | 0.1493 | 0.3331 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.012 | 0.0046 | 0.0104 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.012 | 0.0046 | 0.0104 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.012 | 0.0046 | 0.0046 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0196 | 0.048 | 0.3172 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0018 | 0.0018 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.012 | 0.0046 | 0.0104 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0196 | 0.048 | 0.0999 |
Brugia malayi | Pepsin A precursor | 0.012 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0372 | 0.1493 | 0.1493 |
Plasmodium vivax | aspartyl protease, putative | 0.028 | 0.0963 | 0.2112 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0196 | 0.048 | 0.1186 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0372 | 0.1493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1854 | 1 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0196 | 0.048 | 0.048 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0196 | 0.048 | 0.1186 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.012 | 0.0046 | 0.0046 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0115 | 0.0018 | 0.0064 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.012 | 0.0046 | 0.0104 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0228 | 0.0667 | 0.0667 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0115 | 0.0018 | 0.0064 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0303 | 0.1097 | 0.1097 |
Plasmodium falciparum | plasmepsin I | 0.0196 | 0.048 | 0.0999 |
Plasmodium falciparum | plasmepsin X | 0.028 | 0.0963 | 0.2112 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0536 | 0.0536 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0115 | 0.0018 | 0.0018 |
Plasmodium falciparum | plasmepsin VI | 0.0196 | 0.048 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.0024 | 0.0024 |
Brugia malayi | hypothetical protein | 0.0115 | 0.0018 | 0.0018 |
Echinococcus multilocularis | Mastin | 0.0115 | 0.0018 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0046 | 0.0046 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.012 | 0.0046 | 0.0104 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0205 | 0.0536 | 0.1962 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0115 | 0.0018 | 0.0018 |
Brugia malayi | Protein kinase domain containing protein | 0.0372 | 0.1493 | 0.1493 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0115 | 0.0018 | 0.0064 |
Plasmodium falciparum | plasmepsin IX | 0.028 | 0.0963 | 0.2112 |
Loa Loa (eye worm) | trypsin family protein | 0.0115 | 0.0018 | 0.0018 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0115 | 0.0018 | 0.0064 |
Echinococcus granulosus | Mastin | 0.0115 | 0.0018 | 0.0064 |
Onchocerca volvulus | 0.0372 | 0.1493 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0536 | 0.0536 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.012 | 0.0046 | 0.0104 |
Onchocerca volvulus | 0.012 | 0.0046 | 0.0187 | |
Brugia malayi | Kringle domain containing protein | 0.0372 | 0.1493 | 0.1493 |
Plasmodium falciparum | plasmepsin V | 0.0877 | 0.4391 | 1 |
Brugia malayi | hypothetical protein | 0.012 | 0.0046 | 0.0046 |
Toxoplasma gondii | aspartyl protease ASP5 | 0.0757 | 0.3703 | 1 |
Brugia malayi | hypothetical protein | 0.012 | 0.0046 | 0.0046 |
Schistosoma mansoni | integrin beta subunit | 0.0179 | 0.0382 | 0.1379 |
Leishmania major | hypothetical protein, conserved | 0.0372 | 0.1493 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0372 | 0.1493 | 0.3331 |
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.1493 | 0.1493 |
Echinococcus granulosus | integrin beta 2 | 0.0225 | 0.0646 | 0.4297 |
Plasmodium falciparum | plasmepsin IV | 0.0196 | 0.048 | 0.0999 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0575 | 0.2657 | 1 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0115 | 0.0018 | 0.0064 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0196 | 0.048 | 0.3172 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0018 | 0.0018 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.012 | 0.0046 | 0.0104 |
Plasmodium falciparum | plasmepsin II | 0.0196 | 0.048 | 0.0999 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.012 | 0.0046 | 0.0046 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.012 | 0.0046 | 0.0046 |
Brugia malayi | Trypsin family protein | 0.0205 | 0.0536 | 0.0536 |
Mycobacterium ulcerans | hypothetical protein | 0.0115 | 0.0018 | 0.5 |
Plasmodium vivax | plasmepsin V, putative | 0.0877 | 0.4391 | 1 |
Onchocerca volvulus | 0.0205 | 0.0536 | 0.3511 | |
Toxoplasma gondii | aspartyl protease ASP3 | 0.028 | 0.0963 | 0.2509 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0115 | 0.0018 | 0.0064 |
Brugia malayi | Trypsin family protein | 0.0115 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.048 | 0.048 |
Echinococcus granulosus | enteropeptidase | 0.0115 | 0.0018 | 0.0064 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.012 | 0.0046 | 0.0104 |
Loa Loa (eye worm) | integrin beta-2 | 0.0303 | 0.1097 | 0.1097 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0196 | 0.048 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0115 | 0.0018 | 0.0064 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0196 | 0.048 | 0.1748 |
Echinococcus multilocularis | integrin beta 2 | 0.0225 | 0.0646 | 0.4297 |
Toxoplasma gondii | kringle domain-containing protein | 0.0372 | 0.1493 | 0.3958 |
Schistosoma mansoni | hypothetical protein | 0.0372 | 0.1493 | 0.5588 |
Brugia malayi | Trypsin family protein | 0.0115 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0018 | 0.0018 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0372 | 0.1493 | 0.5 |
Schistosoma mansoni | integrin alpha | 0.0148 | 0.0207 | 0.0715 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0115 | 0.0018 | 0.0064 |
Plasmodium vivax | aspartyl protease, putative | 0.028 | 0.0963 | 0.2112 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0372 | 0.1493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0018 | 0.0018 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0148 | 0.0207 | 0.0207 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0205 | 0.0536 | 0.1962 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0115 | 0.0018 | 0.0064 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.012 | 0.0046 | 0.0046 |
Onchocerca volvulus | 0.012 | 0.0046 | 0.0187 | |
Plasmodium vivax | plasmepsin IV, putative | 0.0196 | 0.048 | 0.0999 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.098 ug ml-1 | Cytotoxic activity against murine P388 leukemia cells | ChEMBL. | 15056007 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 15056007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.