Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.002 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.011 | 0.0061 | 0.0085 |
Echinococcus multilocularis | expressed conserved protein | 0.0103 | 0.0057 | 0.0964 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0007 | 0.0009 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0002 | 0.0282 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0007 | 0.0741 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0012 | 0.0016 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0015 | 0.2156 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0012 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0039 | 0.4906 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0007 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0007 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.0012 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0062 | 0.7863 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0007 | 0.0009 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0002 | 0.3377 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0002 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0111 | 0.0063 | 0.993 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0015 | 0.0409 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0002 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0063 | 0.7944 |
Brugia malayi | CHE-14 protein | 0.0047 | 0.002 | 0.0027 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.0002 | 0.0007 |
Echinococcus granulosus | expressed conserved protein | 0.0103 | 0.0057 | 0.1553 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0002 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0002 | 0.0249 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0111 | 0.0062 | 0.0086 |
Echinococcus multilocularis | tumor protein p63 | 0.0392 | 0.025 | 0.423 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0007 | 0.0835 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.002 | 0.2479 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0015 | 0.238 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0111 | 0.0062 | 0.0086 |
Brugia malayi | hypothetical protein | 0.004 | 0.0015 | 0.0021 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0007 | 0.0741 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0007 | 0.0024 |
Echinococcus multilocularis | protein patched | 0.0047 | 0.002 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0079 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0002 | 0.0003 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0002 | 0.0008 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0063 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0027 | 0.337 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.0007 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0061 | 0.7745 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0002 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0079 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0007 | 0.0009 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0001 | 0.1856 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.4095 | 0.2723 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.4095 | 0.2723 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0001 | 0.1856 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0012 | 0.1476 |
Brugia malayi | Telomerase reverse transcriptase | 1.0897 | 0.7265 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0012 | 0.1858 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.4095 | 0.2723 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.0077 | 0.9707 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0157 | 0.0093 | 0.1571 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0002 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0063 | 0.7944 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.011 | 0.0061 | 0.104 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0047 | 0.002 | 0.0333 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0002 | 0.0038 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0012 | 0.0319 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.0007 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.0007 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.0079 | 0.0073 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0002 | 0.0008 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0027 | 0.3349 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0007 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0002 | 0.0249 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0019 | 0.2941 |
Echinococcus granulosus | tumor protein p63 | 0.0392 | 0.025 | 0.6812 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0002 | 0.0249 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0001 | 0.1856 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0007 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0012 | 0.0198 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0002 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0012 | 0.0319 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0007 | 0.0835 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0015 | 0.0254 |
Echinococcus granulosus | protection of telomeres protein 1 | 0.0567 | 0.0367 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.0007 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0012 | 0.1858 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.0079 | 0.0073 |
Echinococcus multilocularis | protein dispatched 1 | 0.0054 | 0.0024 | 0.0408 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0002 | 0.2988 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0057 | 0.0027 | 0.4216 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0019 | 0.2941 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0007 | 0.0024 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0012 | 0.1858 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.0012 | 0.0319 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0015 | 0.2156 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0007 | 0.5 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.011 | 0.0061 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.011 | 0.0061 | 0.1674 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.4095 | 0.2723 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0019 | 0.2941 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0002 | 0.0554 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.0077 | 0.0106 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0157 | 0.0093 | 0.253 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0002 | 0.0008 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0002 | 0.0061 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0063 | 0.0087 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0007 | 1 |
Echinococcus multilocularis | protection of telomeres protein 1 | 0.0567 | 0.0367 | 0.6209 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0047 | 0.002 | 0.0536 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0002 | 0.0008 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0039 | 0.6176 |
Schistosoma mansoni | patched 1 | 0.0047 | 0.002 | 0.312 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0007 | 0.0835 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0903 | 0.0591 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.0007 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0002 | 0.0249 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.4095 | 0.2723 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.4095 | 0.2723 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0002 | 0.0249 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0019 | 0.2941 |
Giardia lamblia | Telomerase catalytic subunit | 0.4095 | 0.2723 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0002 | 0.0355 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.0077 | 0.9707 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0111 | 0.0062 | 0.7863 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0015 | 0.2156 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0047 | 0.002 | 0.2479 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0007 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0012 | 0.1476 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.4095 | 0.2723 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0063 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0007 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0012 | 0.0016 |
Onchocerca volvulus | 0.0057 | 0.0027 | 0.002 | |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0012 | 0.1858 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0047 | 0.002 | 0.0536 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.0007 | 0.0741 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0015 | 0.2156 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.0002 | 0.0007 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0015 | 0.238 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.0039 | 0.0054 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0001 | 0.1856 |
Brugia malayi | hypothetical protein | 0.0136 | 0.0079 | 0.0109 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.