Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.095 | 0.1005 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.095 | 0.1005 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0232 | 0.9456 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1575 | 0.1666 |
Mycobacterium leprae | conserved hypothetical protein | 0.0038 | 0.095 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.095 | 0.1005 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0846 | 0.0895 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.095 | 0.1005 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.4839 | 0.5118 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.095 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.095 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0846 | 0.0895 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0232 | 0.9456 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0038 | 0.095 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.095 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1575 | 0.1666 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.095 | 0.1005 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.4839 | 0.5118 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1575 | 0.1666 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0232 | 0.9456 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0846 | 0.0895 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.4839 | 0.5118 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0038 | 0.095 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0038 | 0.095 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1575 | 0.1666 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0232 | 0.9456 | 1 |
Giardia lamblia | Kinase, CDC7 | 0.0232 | 0.9456 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0232 | 0.9456 | 1 |
Onchocerca volvulus | 0.0232 | 0.9456 | 1 | |
Onchocerca volvulus | 0.0232 | 0.9456 | 1 | |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.095 | 0.1005 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.095 | 0.1005 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.095 | 0.1005 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.095 | 0.1005 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.095 | 0.1005 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.095 | 0.1005 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.095 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0038 | 0.095 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.095 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.095 | 0.1005 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0232 | 0.9456 | 1 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0232 | 0.9456 | 1 |
Brugia malayi | beta-lactamase | 0.0038 | 0.095 | 0.1005 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.095 | 0.1005 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.095 | 0.1005 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.095 | 0.1005 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.095 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0038 | 0.095 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0232 | 0.9456 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.095 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.