Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0114 | 0.36 | 1 |
Echinococcus multilocularis | adam | 0.0078 | 0.2159 | 0.5999 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2478 | 0.2085 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0213 | 0.7619 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0213 | 0.7619 | 1 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0037 | 0.0498 | 0.1383 |
Mycobacterium tuberculosis | Conserved protein | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0025 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0213 | 0.7619 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0114 | 0.36 | 1 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0078 | 0.2159 | 0.5357 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2159 | 0.1749 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0037 | 0.0498 | 0.1383 |
Echinococcus granulosus | adam | 0.0078 | 0.2159 | 0.5999 |
Loa Loa (eye worm) | angiogenesis inhibito | 0.0042 | 0.0718 | 0.0232 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.3841 | 0.3518 |
Mycobacterium ulcerans | citrate (pro-3S)-lyase subunit beta | 0.0025 | 0 | 0.5 |
Brugia malayi | ADAMTS-like protease | 0.0084 | 0.238 | 0.1981 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0213 | 0.7619 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.3841 | 0.3518 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.067 | 0.0181 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0078 | 0.2159 | 0.1749 |
Brugia malayi | angiogenesis inhibito | 0.0084 | 0.238 | 0.1981 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0114 | 0.36 | 1 |
Trichomonas vaginalis | Citrate lyase beta chain, putative | 0.0025 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0025 | 0 | 0.5 |
Onchocerca volvulus | Papilin homolog | 0.0086 | 0.2478 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.3841 | 0.3518 |
Mycobacterium ulcerans | citrate lyase beta subunit, CitE_2 | 0.0025 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.22 ug/ml | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro | ChEMBL. | No reference |
IC50 | = 3.75 ug/ml | DNDI: Cytotoxicity against L929 mouse fibroblasts, 72 hour. | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei | ChEMBL23 | ||
Mus musculus | ChEMBL23 | ||
Trypanosoma brucei gambiense |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.