Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Starlite/ChEMBL | References |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | uM | Inhibitory activity of compound was evaluated against the inosine monophosphate dehydrogenase -II (IMPDH-II) enzyme; NA : Not active | ChEMBL. | 12270168 |
IC50 (binding) | 0 uM | Inhibitory activity of compound was evaluated against the inosine monophosphate dehydrogenase -II (IMPDH-II) enzyme; NA : Not active | ChEMBL. | 12270168 |
IC50 (binding) | = 0.019 uM | Inhibition of human inosine monophosphate dehydrogenase IMPDH II | ChEMBL. | 12565968 |
IC50 (binding) | = 0.019 uM | Inhibition of inosine-5'-monophosphate dehydrogenase 2. | ChEMBL. | 12781195 |
IC50 (binding) | = 0.019 uM | In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2. | ChEMBL. | 12270177 |
IC50 (binding) | = 0.019 uM | Inhibition of human inosine monophosphate dehydrogenase IMPDH II | ChEMBL. | 12565968 |
IC50 (binding) | = 0.019 uM | Inhibition of inosine-5'-monophosphate dehydrogenase 2. | ChEMBL. | 12781195 |
IC50 (binding) | = 0.019 uM | In vitro inhibition of Inosine-5'-monophosphate dehydrogenase 2. | ChEMBL. | 12270177 |
IC50 (binding) | = 0.055 uM | Inhibitory activity of the compound against inosine monophosphate dehydrogenase IMPDH type I | ChEMBL. | 12565968 |
IC50 (binding) | = 0.055 uM | Inhibitory activity of the compound against inosine monophosphate dehydrogenase IMPDH type I | ChEMBL. | 12565968 |
IC50 (functional) | = 0.32 uM | Inhibitory activity of the compound against CEM cell proliferation | ChEMBL. | 12565968 |
IC50 (functional) | = 0.32 uM | Inhibitory activity of the compound against CEM cell proliferation | ChEMBL. | 12565968 |
IC50 (functional) | = 1 uM | Inhibitory concentration against T-cell proliferation response in a CEM cell line (BMS-337197,CEM) | ChEMBL. | 12392738 |
IC50 (functional) | = 1 uM | Inhibition of CEM (human leukaemia) cell proliferation. | ChEMBL. | 14505670 |
IC50 (functional) | < 1 uM | Inhibition of human T-lymphoblast CEM cell (ATCC) proliferation; At this concentration no inhibition was observed | ChEMBL. | 12270168 |
IC50 (functional) | = 1 uM | Inhibitory concentration against T-cell proliferation response in a CEM cell line (BMS-337197,CEM) | ChEMBL. | 12392738 |
IC50 (functional) | = 1 uM | Inhibition of CEM (human leukaemia) cell proliferation. | ChEMBL. | 14505670 |
IC50 (functional) | < 1 uM | Inhibition of human T-lymphoblast CEM cell (ATCC) proliferation; At this concentration no inhibition was observed | ChEMBL. | 12270168 |
IC50 (functional) | = 2.3 uM | Inhibition of CEM cell proliferation. | ChEMBL. | 12781195 |
IC50 (functional) | = 2.3 uM | Inhibition of CEM cell proliferation. | ChEMBL. | 12781195 |
IC50 (binding) | = 19 uM | Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determined | ChEMBL. | 12392738 |
IC50 (binding) | = 19 uM | Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme | ChEMBL. | 14505670 |
IC50 (binding) | = 19 uM | Inhibitory concentration against Inosine-5'-monophosphate dehydrogenase 2 was determined | ChEMBL. | 12392738 |
IC50 (binding) | = 19 uM | Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme | ChEMBL. | 14505670 |
Ratio (binding) | = 2.9 | Ratio of IC50(Type I) to IC50(Type II) | ChEMBL. | 12565968 |
Ratio (binding) | = 2.9 | Ratio of IC50(Type I) to IC50(Type II) | ChEMBL. | 12565968 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12270168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
6 literature references were collected for this gene.