Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical alanine rich protein | 0.0003 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0003 | 0 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0005 | 0.0129 | 0.1955 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0881 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0026 | 0.1426 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0005 | 0.0129 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 1 | 1 |
Plasmodium vivax | ATP-dependent DNA helicase Q1, putative | 0.0005 | 0.0116 | 0.1298 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0011 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 1 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0461 | 0.0461 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0011 | 0.0461 | 0.0461 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0661 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0026 | 0.1426 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0026 | 0.1426 | 0.1426 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0005 | 0.0129 | 0.1955 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0017 | 0.0894 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0161 | 1 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0026 | 0.1426 | 0.1426 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0005 | 0.0129 | 0.1196 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0011 | 0.0461 | 0.0461 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0661 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0461 | 0.524 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0011 | 0.0461 | 0.0461 |
Mycobacterium leprae | conserved hypothetical protein | 0.0003 | 0 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0661 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0014 | 0.0661 | 0.4636 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0461 | 0.4273 |
Echinococcus granulosus | bloom syndrome protein | 0.0026 | 0.1426 | 0.1426 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0661 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.108 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0461 | 0.4273 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0005 | 0.0129 | 0.1467 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0011 | 0.0461 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0161 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.8048 | 0.8048 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0461 | 0.524 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0129 | 0.0129 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0011 | 0.0461 | 0.0461 |
Echinococcus multilocularis | bloom syndrome protein | 0.0026 | 0.1426 | 0.1426 |
Entamoeba histolytica | recQ family helicase, putative | 0.0005 | 0.0116 | 0.1756 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0461 | 0.0461 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.1226 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0005 | 0.0129 | 0.1955 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 29 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.