Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Thromboxane A2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | opsin-like receptor | Thromboxane A2 receptor | 341 aa | 313 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0144 | 0.0811 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.1903 | 0.3407 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0144 | 0.0811 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0144 | 0.0811 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0306 | 0.1903 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0323 | 0.2019 | 0.3723 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0144 | 0.0811 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0144 | 0.0811 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0144 | 0.0811 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0811 | 0.1452 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0306 | 0.1903 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0144 | 0.0811 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0144 | 0.0811 | 0.5 |
Echinococcus multilocularis | 0.0144 | 0.0811 | 0.4263 | |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0144 | 0.0811 | 0.4263 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0144 | 0.0811 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0144 | 0.0811 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0144 | 0.0811 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0144 | 0.0811 | 0.4263 |
Onchocerca volvulus | CoRest homolog | 0.0852 | 0.5587 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0144 | 0.0811 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0144 | 0.0811 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1506 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0144 | 0.0811 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0144 | 0.0811 | 0.4263 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0811 | 0.1452 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.1903 | 0.3407 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0144 | 0.0811 | 0.4263 |
Schistosoma mansoni | amine oxidase | 0.0144 | 0.0811 | 0.4263 |
Loa Loa (eye worm) | hypothetical protein | 0.0828 | 0.5424 | 0.9708 |
Brugia malayi | hypothetical protein | 0.0144 | 0.0811 | 0.1496 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0162 | 0.0927 | 0.171 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.0927 | 0.166 |
Loa Loa (eye worm) | hypothetical protein | 0.0323 | 0.2019 | 0.3614 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0306 | 0.1903 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0852 | 0.5587 | 1 |
Brugia malayi | Myb-like DNA-binding domain containing protein | 0.0828 | 0.5424 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1362 | 0.9025 | 1 |
Onchocerca volvulus | 0.0323 | 0.2019 | 0.3614 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 10.8 | In vitro Thromboxane A2 (TXA2) receptor antagonism was tested by its ability to inhibit the contraction of rat aorta induced by the stable thromboxane agonist U-46,619 | ChEMBL. | 9873486 |
pA2 (functional) | = 10.8 | In vitro Thromboxane A2 (TXA2) receptor antagonism was tested by its ability to inhibit the contraction of rat aorta induced by the stable thromboxane agonist U-46,619 | ChEMBL. | 9873486 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.