Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.7651 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0431 | 0.0431 | 0.0418 |
Chlamydia trachomatis | dihydrofolate reductase | 0.7651 | 1 | 0.5 |
Onchocerca volvulus | 0.0117 | 0.0014 | 0.013 | |
Echinococcus granulosus | dihydrofolate reductase | 0.7651 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.7651 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4061 | 0.5241 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.7651 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4061 | 0.5241 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0907 | 0.1061 | 0.1049 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4061 | 0.5241 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0907 | 0.1061 | 0.0659 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4061 | 0.5241 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.7651 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0907 | 0.1061 | 0.1049 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0431 | 0.0431 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.7651 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4061 | 0.5241 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0907 | 0.1061 | 0.1049 |
Onchocerca volvulus | 0.0907 | 0.1061 | 1 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4061 | 0.5241 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.7651 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.7651 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 14 nM | Inhibition of Thrombin | ChEMBL. | 9357536 |
Ki (binding) | = 2500 nM | In vitro inhibition of human trypsin. | ChEMBL. | 9357536 |
Ki (binding) | = 2.5 uM | In vitro inhibition of human trypsin. | ChEMBL. | 9357536 |
Ki (binding) | = 84 uM | Inhibitory activity against serine protease TPA | ChEMBL. | 9357536 |
Ki (binding) | = 170 uM | Inhibitory activity against serine protease plasma kallikrein | ChEMBL. | 9357536 |
Ki (binding) | = 176 uM | Inhibitory activity against serine protease plasmin | ChEMBL. | 9357536 |
Ki (binding) | = 220 uM | Inhibitory activity against serine protease Coagulation factor X | ChEMBL. | 9357536 |
k_on (binding) | = 0.0000023 M-1 s-1 | Second-order constant of inactivation against thrombin | ChEMBL. | 9357536 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.