Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0714 | 1 | 1 |
Schistosoma mansoni | fatty acid desaturase | 0.0278 | 0.1805 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0714 | 1 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0618 | 0.8195 | 1 |
Loa Loa (eye worm) | FAT-3 protein | 0.0277 | 0.1793 | 0.2188 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1793 | 0.2188 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0618 | 0.8195 | 0.5 |
Onchocerca volvulus | 0.0713 | 0.9988 | 1 | |
Leishmania major | fatty-acid desaturase, putative | 0.0714 | 1 | 1 |
Onchocerca volvulus | 0.0713 | 0.9988 | 1 | |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0618 | 0.8195 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0618 | 0.8195 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.076 g | Antitumor activity against mouse S180 cells xenografted in ICR mouse assessed as tumor weight at 44.64 umol/kg/day, ip administered for 7 consecutive days after 24 hrs of tumor implantation measured after 24 hrs post dose | ChEMBL. | 19631550 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.