Detailed information for compound 105154

Basic information

Technical information
  • TDR Targets ID: 105154
  • Name: 3,4-dihydroxy-N-[(2R,3R,4S,5R)-4-hydroxy-5-(h ydroxymethyl)-2-[6-(naphthalen-1-ylmethylamin o)purin-9-yl]oxolan-3-yl]benzamide
  • MW: 542.543 | Formula: C28H26N6O6
  • H donors: 6 H acceptors: 8 LogP: 2.45 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)NC(=O)c1ccc(c(c1)O)O)n1cnc2c1ncnc2NCc1cccc2c1cccc2
  • InChi: 1S/C28H26N6O6/c35-12-21-24(38)22(33-27(39)16-8-9-19(36)20(37)10-16)28(40-21)34-14-32-23-25(30-13-31-26(23)34)29-11-17-6-3-5-15-4-1-2-7-18(15)17/h1-10,13-14,21-22,24,28,35-38H,11-12H2,(H,33,39)(H,29,30,31)/t21-,22-,24-,28-/m1/s1
  • InChiKey: DXZDIVMKEICYMY-XABBOIKWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dihydroxy-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-(1-naphthylmethylamino)purin-9-yl]tetrahydrofuran-3-yl]benzamide
  • 3,4-dihydroxy-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-(1-naphthalenylmethylamino)-9-purinyl]-3-tetrahydrofuranyl]benzamide
  • 3,4-dihydroxy-N-[(2R,3R,4S,5R)-4-hydroxy-5-methylol-2-[6-(1-naphthylmethylamino)purin-9-yl]tetrahydrofuran-3-yl]benzamide
  • 3,4-dihydroxy-N-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-[6-(1-naphthylmethylamino)-9-purinyl]-3-tetrahydrofuranyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium parvum glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma congolense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Cryptosporidium hominis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, cytosolic Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania braziliensis glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania mexicana glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium yoelii glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania infantum glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma japonicum ko:K00134 glyceraldehyde 3-phosphate dehydrogenase [EC1.2.1.12], putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania donovani glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium berghei glyceraldehyde-3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Plasmodium knowlesi glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Neospora caninum Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12), related Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Babesia bovis glyceraldehyde-3-phosphate dehydrogenase protein Get druggable targets OG5_126628 All targets in OG5_126628
Theileria parva glyceraldehyde-3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative Get druggable targets OG5_126628 All targets in OG5_126628
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase Get druggable targets OG5_126628 All targets in OG5_126628
Candida albicans glyceraldehyde-3-phosphate dehydrogenase (GAPDH), C. albicans cell surface antigen Get druggable targets OG5_126628 All targets in OG5_126628
Trypanosoma brucei gambiense glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative Get druggable targets OG5_126628 All targets in OG5_126628
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal Get druggable targets OG5_126628 All targets in OG5_126628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 331 aa 331 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0177 0.0449
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0121 0.0611 0.0572
Onchocerca volvulus 0.0098 0.043 0.0491
Loa Loa (eye worm) hypothetical protein 0.0735 0.5341 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0065 0.0177 0.0255
Schistosoma mansoni nAChR subunit 0.0065 0.0177 0.0136
Toxoplasma gondii PAN domain-containing protein 0.0909 0.6677 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0078 0.0279 0.2444
Brugia malayi PAN domain containing protein 0.0098 0.043 0.0733
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0177 0.0255
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Toxoplasma gondii PAN domain-containing protein 0.0098 0.043 0.0189
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.031 0.2847
Loa Loa (eye worm) hypothetical protein 0.0051 0.0075 0.0062
Onchocerca volvulus 0.0175 0.1026 0.1646
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0065 0.0177 0.0255
Onchocerca volvulus 0.0121 0.0611 0.0842
Onchocerca volvulus 0.0098 0.043 0.0491
Loa Loa (eye worm) hypothetical protein 0.0121 0.0611 0.1075
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.031 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.043 0.0733
Onchocerca volvulus 0.0735 0.5341 1
Onchocerca volvulus 0.0098 0.043 0.0491
Loa Loa (eye worm) hypothetical protein 0.0098 0.043 0.0733
Echinococcus granulosus transmembrane protease serine 3 0.0121 0.0611 0.1555
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.031 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0065 0.0177 0.0255
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0121 0.0611 0.0572
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0065 0.0177 0.0255
Brugia malayi PAN domain containing protein 0.0098 0.043 0.0733
Echinococcus granulosus tissue type plasminogen activator 0.0153 0.0857 0.218
Loa Loa (eye worm) ACC-1 protein 0.0065 0.0177 0.0255
Onchocerca volvulus 0.0203 0.1242 0.2063
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0435 0.1106
Loa Loa (eye worm) TK/ROR protein kinase 0.0153 0.0857 0.1539
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0177 0.0136
Loa Loa (eye worm) hypothetical protein 0.0098 0.043 0.0733
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0065 0.0177 0.0255
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0177 0.0449
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.031 0.5
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0052 0.002
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0065 0.0177 0.0449
Toxoplasma gondii microneme protein MIC4 0.0098 0.043 0.0189
Loa Loa (eye worm) hypothetical protein 0.0203 0.1242 0.2266
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.031 0.0787
Echinococcus granulosus Mastin 0.0121 0.0611 0.1555
Brugia malayi Cation transporter family protein 0.0203 0.1242 0.2266
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.031 0.2847
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0121 0.0611 0.0572
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.031 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0177 0.0255
Schistosoma mansoni voltage-gated cation channel 0.0115 0.0562 0.0523
Brugia malayi PAN domain containing protein 0.0098 0.043 0.0733
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0098 0.043 0.0189
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0203 0.1242 0.1206
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Toxoplasma gondii PAN domain-containing protein 0.0098 0.043 0.0189
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0177 0.0255
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0065 0.0177 0.0449
Brugia malayi PAN domain containing protein 0.0098 0.043 0.0733
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0121 0.0611 0.0572
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0149 0.0826 0.0787
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0052 0.002
Loa Loa (eye worm) hypothetical protein 0.0098 0.043 0.0733
Echinococcus granulosus glycine receptor subunit beta 0.0065 0.0177 0.0449
Loa Loa (eye worm) hypothetical protein 0.0049 0.0052 0.002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Schistosoma mansoni serine-type protease inhibitor 0.134 1 1
Brugia malayi Cation transporter family protein 0.0065 0.0177 0.0255
Onchocerca volvulus 0.0175 0.1026 0.1646
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0121 0.0611 0.0572
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0552 0.3933 0.7344
Brugia malayi PAN domain containing protein 0.0098 0.043 0.0733
Brugia malayi PAN domain containing protein 0.0098 0.043 0.0733
Schistosoma mansoni nAChR subunit 0.0065 0.0177 0.0136
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0047 0.0042 0.0106
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.031 0.5
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0115 0.0562 0.143
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0177 0.0136
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0065 0.0177 0.0449
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0177 0.0449
Loa Loa (eye worm) calcium channel 0.0115 0.0562 0.0983
Echinococcus granulosus glycine receptor subunit alpha 1 0.0065 0.0177 0.0449
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0121 0.0611 0.1555
Echinococcus granulosus potassium voltage gated channel protein 0.0552 0.3933 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0078 0.0279 0.8584
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Schistosoma mansoni hypothetical protein 0.0175 0.1026 0.0989
Loa Loa (eye worm) hypothetical protein 0.0175 0.1026 0.1858
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0082 0.031 0.5
Toxoplasma gondii hypothetical protein 0.0098 0.043 0.0189
Onchocerca volvulus 0.0098 0.043 0.0491
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.031 0.2847
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.0114 0.0137
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0203 0.1242 0.1206
Brugia malayi PAN domain containing protein 0.0098 0.043 0.0733
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.031 1
Brugia malayi Trypsin family protein 0.0121 0.0611 0.1075
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0065 0.0177 0.0449
Brugia malayi Muscle positioning protein 4 0.0175 0.1026 0.1858
Onchocerca volvulus 0.0175 0.1026 0.1646
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0065 0.0177 0.0449
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.031 0.0787
Brugia malayi Trypsin-like protease protein 5 0.0121 0.0611 0.1075
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0177 0.0255
Echinococcus granulosus voltage gated potassium channel 0.0047 0.0042 0.0106
Onchocerca volvulus 0.0121 0.0611 0.0842
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0121 0.0611 0.1555
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.031 0.2847
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0115 0.0562 0.0983
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.031 0.0269
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Onchocerca volvulus 0.0614 0.4408 0.8194
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.0042 0.0106
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0121 0.0611 0.1555
Echinococcus multilocularis potassium voltage gated channel protein 0.0047 0.0042 0.0106
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0047 0.0042 0.0106
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.031 0.0787
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.0857 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0065 0.0177 0.0449
Schistosoma mansoni hypothetical protein 0.0153 0.0857 0.0819
Onchocerca volvulus 0.0203 0.1242 0.2063
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0047 0.0042 0.0106
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.031 0.2847
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.031 0.0506
Loa Loa (eye worm) hypothetical protein 0.0121 0.0611 0.1075
Loa Loa (eye worm) hypothetical protein 0.0098 0.043 0.0733
Loa Loa (eye worm) LGC-31 protein 0.0065 0.0177 0.0255
Brugia malayi PAN domain containing protein 0.0098 0.043 0.0733
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0177 0.0255
Loa Loa (eye worm) hypothetical protein 0.0175 0.1026 0.1858
Loa Loa (eye worm) trypsin family protein 0.0121 0.0611 0.1075
Toxoplasma gondii hypothetical protein 0.0098 0.043 0.0189
Echinococcus multilocularis voltage dependent calcium channel 0.0115 0.0562 0.143
Brugia malayi PAN domain containing protein 0.0098 0.043 0.0733
Echinococcus granulosus glycine receptor subunit beta 0.0065 0.0177 0.0449
Brugia malayi excitatory GABA receptor EXP-1A 0.0065 0.0177 0.0255
Brugia malayi CUB domain containing protein 0.006 0.0139 0.0183
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0065 0.0177 0.0255
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0115 0.0562 0.0523
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Echinococcus multilocularis Mastin 0.0121 0.0611 0.1555
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Echinococcus granulosus potassium voltage gated channel protein 0.0047 0.0042 0.0106
Onchocerca volvulus 0.0098 0.043 0.0491
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0065 0.0177 0.0255
Echinococcus multilocularis sodium channel protein 0.0061 0.0146 0.037
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0065 0.0177 0.0255
Echinococcus multilocularis transmembrane protease serine 3 0.0121 0.0611 0.1555
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.0092 0.0234
Loa Loa (eye worm) hypothetical protein 0.0098 0.043 0.0733
Leishmania major hypothetical protein, conserved 0.0153 0.0857 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0139 0.0183
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Echinococcus multilocularis nAChR subunit 0.0065 0.0177 0.0449
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Schistosoma mansoni nAChR subunit 0.0065 0.0177 0.0136
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0115 0.0562 0.143
Onchocerca volvulus 0.0121 0.0611 0.0842
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0115 0.0562 0.143
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0065 0.0177 0.0255
Loa Loa (eye worm) hypothetical protein 0.006 0.0139 0.0183
Loa Loa (eye worm) hypothetical protein 0.0121 0.0611 0.1075
Echinococcus multilocularis transfer RNA-Gly 0.0047 0.0042 0.0106
Brugia malayi Protein kinase domain containing protein 0.0153 0.0857 0.1539
Loa Loa (eye worm) hypothetical protein 0.0178 0.1047 0.1898
Echinococcus multilocularis voltage dependent calcium channel 0.0115 0.0562 0.143
Toxoplasma gondii subtilisin SUB12 0.0098 0.043 0.0189
Onchocerca volvulus 0.0121 0.0611 0.0842
Onchocerca volvulus 0.0203 0.1242 0.2063
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Schistosoma mansoni hypothetical protein 0.0121 0.0611 0.0572
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0435 0.1106
Loa Loa (eye worm) PAN domain-containing protein 0.0098 0.043 0.0733
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0735 0.5341 0.5321
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0065 0.0177 0.0255
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0082 0.031 0.0787
Onchocerca volvulus 0.0098 0.043 0.0491
Toxoplasma gondii microneme protein MIC17C 0.0098 0.043 0.0189
Echinococcus multilocularis potassium voltage gated channel protein 0.0552 0.3933 1
Onchocerca volvulus 0.0098 0.043 0.0491
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0082 0.031 0.5
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0115 0.0562 0.0523
Plasmodium falciparum cysteine repeat modular protein 1 0.0153 0.0857 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0082 0.031 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0065 0.0177 0.0449
Loa Loa (eye worm) PAN domain-containing protein 0.0098 0.043 0.0733
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0115 0.0562 0.143
Loa Loa (eye worm) hypothetical protein 0.0115 0.0562 0.0983
Schistosoma mansoni nAChR subunit 0.0065 0.0177 0.0136
Toxoplasma gondii kringle domain-containing protein 0.0153 0.0857 0.086
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0065 0.0177 0.0449
Brugia malayi hypothetical protein 0.0121 0.0611 0.1075
Toxoplasma gondii microneme protein MIC17B 0.0098 0.043 0.0189
Brugia malayi Trypsin family protein 0.0121 0.0611 0.1075
Onchocerca volvulus 0.0175 0.1026 0.1646
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0115 0.0562 0.143
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.0092 0.0095
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.031 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0065 0.0177 0.0449
Echinococcus granulosus nAChR subunit 0.0065 0.0177 0.0449
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0279 0.0239
Brugia malayi PAN domain containing protein 0.0098 0.043 0.0733
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0065 0.0177 0.0136
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0115 0.0562 0.143
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0115 0.0562 0.143
Onchocerca volvulus 0.0153 0.0857 0.1318
Echinococcus granulosus glycoprotein Antigen 5 0.0121 0.0611 0.1555
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0065 0.0177 0.0449
Echinococcus multilocularis glycine receptor subunit beta 0.0065 0.0177 0.0449
Brugia malayi SEA domain containing protein 0.0175 0.1026 0.1858
Echinococcus multilocularis shaker cognate 0.0047 0.0042 0.0106
Schistosoma mansoni voltage-gated potassium channel 0.0552 0.3933 0.3908
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0065 0.0177 0.0449
Echinococcus multilocularis enteropeptidase 0.0121 0.0611 0.1555
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0795 0.5801 0.5783
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0121 0.0611 0.1555
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.031 0.2847
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0155 0.0215
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0082 0.031 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0095
Schistosoma mansoni hypothetical protein 0.0121 0.0611 0.0572
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0065 0.0177 0.0255
Onchocerca volvulus 0.0098 0.043 0.0491
Onchocerca volvulus 0.0098 0.043 0.0491
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0065 0.0177 0.0136
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0065 0.0177 0.0449
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Loa Loa (eye worm) hypothetical protein 0.0121 0.0611 0.1075
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0047 0.0042 0.0106
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0177 0.0255
Loa Loa (eye worm) hypothetical protein 0.0153 0.0857 0.1539
Schistosoma mansoni nAChR subunit 0.0065 0.0177 0.0136
Loa Loa (eye worm) hypothetical protein 0.0121 0.0611 0.1075
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.031 1
Mycobacterium ulcerans hypothetical protein 0.0121 0.0611 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0047 0.0042 0.0106
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0177 0.0449
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Loa Loa (eye worm) hypothetical protein 0.0203 0.1242 0.2266
Echinococcus multilocularis tissue type plasminogen activator 0.0153 0.0857 0.218
Onchocerca volvulus 0.0175 0.1026 0.1646
Toxoplasma gondii microneme protein MIC17A 0.0098 0.043 0.0189
Echinococcus granulosus potassium voltage gated channel protein 0.0047 0.0042 0.0106
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0153 0.0857 1
Loa Loa (eye worm) PAN domain-containing protein 0.0098 0.043 0.0733
Loa Loa (eye worm) hypothetical protein 0.0098 0.043 0.0733
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0082 0.031 0.2847
Loa Loa (eye worm) hypothetical protein 0.0552 0.3933 0.7344
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0047 0.0042 0.0106
Loa Loa (eye worm) DOMON domain-containing protein 0.0175 0.1026 0.1858
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0177 0.0255
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0082 0.031 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0177 0.0255
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0528 0.3748 0.953
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0065 0.0177 0.0449
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Echinococcus granulosus enteropeptidase 0.0121 0.0611 0.1555
Echinococcus granulosus shaker cognate 0.0047 0.0042 0.0106
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0065 0.0177 0.0449
Brugia malayi Trypsin family protein 0.0735 0.5341 1
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0047 0.0042 0.0106
Onchocerca volvulus 0.0098 0.043 0.0491
Toxoplasma gondii microneme protein, putative 0.0098 0.043 0.0189
Loa Loa (eye worm) PAN domain-containing protein 0.0098 0.043 0.0733
Schistosoma mansoni nAChR subunit 0.0065 0.0177 0.0136
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.031 0.0269
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0552 0.3933 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0061 0.0146 0.037
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.031 0.2847
Echinococcus multilocularis potassium voltage gated channel protein 0.0047 0.0042 0.0106
Onchocerca volvulus 0.0121 0.0611 0.0842
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0082 0.031 0.5
Echinococcus multilocularis glycoprotein Antigen 5 0.0121 0.0611 0.1555
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0082 0.031 0.2847
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0065 0.0177 0.0255
Toxoplasma gondii PAN domain-containing protein 0.0098 0.043 0.0189
Loa Loa (eye worm) hypothetical protein 0.0735 0.5341 1
Brugia malayi Trypsin family protein 0.0121 0.0611 0.1075
Loa Loa (eye worm) ACC-1 protein 0.0065 0.0177 0.0255
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0057 0.0114 0.0137
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0082 0.031 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0065 0.0177 0.0255
Echinococcus granulosus voltage dependent calcium channel 0.0115 0.0562 0.143
Echinococcus multilocularis glycine receptor subunit beta 0.0065 0.0177 0.0449
Toxoplasma gondii PAN domain-containing protein 0.0098 0.043 0.0189
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0065 0.0177 0.0449
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0121 0.0611 0.1075
Brugia malayi jmjC domain containing protein 0.0098 0.0435 0.0742
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0065 0.0177 0.0255
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0054 0.0092 0.0234
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Schistosoma mansoni voltage-gated potassium channel 0.0552 0.3933 0.3908
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0054 0.0092 0.0095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0052 0.002
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.031 0.0269
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0065 0.0177 0.0449
Brugia malayi Kringle domain containing protein 0.0153 0.0857 0.1539
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0082 0.031 0.0269
Schistosoma mansoni nAChR subunit 0.0065 0.0177 0.0136
Schistosoma mansoni cercarial elastase (S01 family) 0.0121 0.0611 0.0572
Onchocerca volvulus 0.0098 0.043 0.0491
Loa Loa (eye worm) PAN domain-containing protein 0.0098 0.043 0.0733
Toxoplasma gondii PAN/Apple domain-containing protein 0.0098 0.043 0.0189
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0255
Brugia malayi Cation transporter family protein 0.0065 0.0177 0.0255
Toxoplasma gondii PAN domain-containing protein 0.0909 0.6677 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 18 uM Inhibitory activity against Leishmania mexicana GAPDH ChEMBL. 11405646
IC50 (binding) = 18 uM Inhibitory activity against Leishmania mexicana GAPDH ChEMBL. 11405646

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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