TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 400.476 | Formula: C23H24N6O
H donors: 2 H acceptors: 4 LogP: 2.66 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc(cc1)C(c1cccnc1)N1CCC(CC1)NC(=O)c1[nH]nc(c1)C
InChi: 1S/C23H24N6O/c1-16-13-21(28-27-16)23(30)26-20-8-11-29(12-9-20)22(19-3-2-10-25-15-19)18-6-4-17(14-24)5-7-18/h2-7,10,13,15,20,22H,8-9,11-12H2,1H3,(H,26,30)(H,27,28)
InChiKey: MRDZWDBRAZYGDD-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	neuropeptide F receptor	0.0039	0.0055	0.0055
Brugia malayi	G-protein coupled receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Mycobacterium tuberculosis	Probable oxidoreductase	0.0109	0.0281	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0055	0.0055
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Echinococcus multilocularis	geminin	0.0198	0.0565	0.0565
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.0063	0.0063
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.0055	0.0055
Brugia malayi	glutathione reductase	0.0043	0.0069	0.0069
Brugia malayi	Dopamine receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.0055	0.0055
Plasmodium falciparum	glutathione reductase	0.0043	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Schistosoma mansoni	amine GPCR	0.0039	0.0055	0.0055
Toxoplasma gondii	isoprenylcysteine carboxyl methyltransferase (icmt) family protein	0.3151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Giardia lamblia	Isoprenylcysteine carboxyl methyltransferase	0.3151	1	1
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.3151	1	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0039	0.0055	0.0055
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.0055	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0055	0.0055
Brugia malayi	hypothetical protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Echinococcus multilocularis	chromobox protein 1	0.0081	0.0192	0.0192
Schistosoma mansoni	neuropeptide receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis		0.3151	1	1
Brugia malayi	GnHR receptor homolog	0.0039	0.0055	0.0055
Echinococcus granulosus	jumonji domain containing protein	0.0047	0.0083	0.0083
Echinococcus granulosus	dro:myosuppressin receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.0055	0.0055
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0098	0.0246	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	chromobox protein 1	0.0081	0.0192	0.0192
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0044	0.0071	0.0071
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0039	0.0055	0.3006
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0039	0.0055	0.0055
Loa Loa (eye worm)	melatonin receptor type 1A	0.0039	0.0055	0.0055
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.0055	0.0055
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0039	0.0055	0.0055
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.0055	0.0055
Brugia malayi	G protein-coupled receptor F59B2.13	0.0039	0.0055	0.0055
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	biogenic amine receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus granulosus	neuropeptide FF receptor 2	0.0039	0.0055	0.0055
Trichomonas vaginalis	chromobox protein, putative	0.0049	0.0089	0.0089
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.0055	0.0055
Echinococcus granulosus	7tm_1 domain containing protein	0.0039	0.0055	0.0055
Brugia malayi	jmjC domain containing protein	0.0112	0.0288	0.0288
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.0055	0.0055
Brugia malayi	ORL1-like opioid receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	jmjC domain-containing protein	0.007	0.0157	0.0157
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.0055	0.0055
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0039	0.0055	0.0055
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.3151	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0039	0.0055	0.0055
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0034	0.0041	0.0041
Echinococcus multilocularis	g-protein coupled receptor	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Schistosoma mansoni	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus multilocularis	somatostatin receptor	0.0039	0.0055	0.0055
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0041	0.0041
Mycobacterium tuberculosis	Probable dehydrogenase	0.0098	0.0246	0.0568
Brugia malayi	follicle stimulating hormone receptor	0.0039	0.0055	0.0055
Brugia malayi	putative neuropeptide receptor	0.0039	0.0055	0.0055
Leishmania major	trypanothione reductase	0.0043	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus granulosus	neuropeptide s receptor	0.0039	0.0055	0.0055
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.0055	0.0055
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0041	0.0041
Brugia malayi	hypothetical protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	biogenic amine receptor	0.0039	0.0055	0.0055
Brugia malayi	hypothetical protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0039	0.0055	0.0055
Brugia malayi	AKH receptor	0.0039	0.0055	0.0055
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.3151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0055	0.0055
Toxoplasma gondii	thioredoxin reductase	0.0043	0.0069	0.0069
Onchocerca volvulus		0.0039	0.0055	0.3006
Brugia malayi	hypothetical protein	0.0039	0.0055	0.0055
Brugia malayi	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0055	0.0055
Echinococcus multilocularis	serotonin receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Brugia malayi	hypothetical protein	0.0039	0.0055	0.0055
Brugia malayi	Bromodomain containing protein	0.0034	0.0041	0.0041
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0039	0.0055	0.0055
Brugia malayi	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.0055	0.0055
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0109	0.0281	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	opsin-like receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Plasmodium falciparum	phd finger protein, putative	0.0034	0.0041	0.0041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus granulosus	orexin receptor type 2	0.0039	0.0055	0.0055
Plasmodium falciparum	protein-S-isoprenylcysteine O-methyltransferase, putative	0.3151	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	TYRA-2 protein	0.0039	0.0055	0.0055
Brugia malayi	Melatonin receptor type 1A	0.0039	0.0055	0.0055
Schistosoma mansoni	neuropeptide receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	hypothetical protein	0.0039	0.0055	0.0055
Trypanosoma brucei	trypanothione reductase	0.0043	0.0069	0.0069
Echinococcus multilocularis	lysine specific demethylase 5A	0.0041	0.0063	0.0063
Loa Loa (eye worm)	heterochromatin protein 1	0.0081	0.0192	0.0192
Echinococcus multilocularis	peregrin	0.0034	0.0041	0.0041
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	protein-S isoprenylcysteine O-methyltransferase	0.3151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	opsin-like receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	hypothetical protein	0.0198	0.0565	0.0565
Onchocerca volvulus		0.0039	0.0055	0.3006
Brugia malayi	G protein-coupled receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	biogenic amine receptor	0.0039	0.0055	0.0055
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0098	0.0246	0.0568
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Schistosoma mansoni	hypothetical protein	0.0198	0.0565	0.0565
Echinococcus granulosus	neuropeptide receptor A26	0.0039	0.0055	0.0055
Schistosoma mansoni	hypothetical protein	0.0039	0.0055	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0078	0.0078
Loa Loa (eye worm)	transcription factor SMAD2	0.0136	0.0366	0.0366
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0034	0.0041	0.0041
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.3151	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0055	0.0055
Brugia malayi	neuropeptide F receptor	0.0039	0.0055	0.0055
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0039	0.0055	0.0055
Echinococcus granulosus	g protein coupled receptor	0.0039	0.0055	0.0055
Brugia malayi	PHD-finger family protein	0.0034	0.0041	0.0041
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0109	0.0281	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.0055	0.0055
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0039	0.0055	0.0055
Schistosoma mansoni	amine GPCR	0.0039	0.0055	0.0055
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.3151	1	1
Echinococcus granulosus	serotonin receptor	0.0039	0.0055	0.0055
Brugia malayi	larval opioid receptor	0.0039	0.0055	0.0055
Echinococcus granulosus	somatostatin receptor	0.0039	0.0055	0.0055
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.0055	0.0055
Trichomonas vaginalis	chromobox protein, putative	0.0049	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0118	0.0118
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0098	0.0246	0.0568
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.0055	0.0055
Echinococcus granulosus	peregrin	0.0034	0.0041	0.0041
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	jumonji domain containing protein	0.0047	0.0083	0.0083
Schistosoma mansoni	hypothetical protein	0.0034	0.0041	0.0041
Echinococcus granulosus	protein S isoprenylcysteine O methyltransferase	0.3151	1	1
Echinococcus granulosus	neuropeptide receptor	0.0039	0.0055	0.0055
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0039	0.0055	0.0055
Brugia malayi	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	neuropeptide receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Trypanosoma cruzi	trypanothione reductase, putative	0.0043	0.0069	0.0069
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0041	0.0041
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0041	0.0041
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.0055	0.0055
Brugia malayi	jmjC domain containing protein	0.0041	0.0063	0.0063
Brugia malayi	RE15519p	0.0039	0.0055	0.0055
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.0055	0.0055
Brugia malayi	Serotonin receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.3151	1	1
Brugia malayi	Serotonin receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	neuropeptide f receptor 76f	0.0039	0.0055	0.0055
Echinococcus granulosus	PHD finger protein rhinoceros	0.0034	0.0041	0.0041
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0039	0.0055	0.3006
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0035	0.0035
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.0063	0.0063
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0039	0.0055	0.0055
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0	0.5
Echinococcus granulosus	hypothetical protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.0055	0.0055
Leishmania major	prenyl protein specific carboxyl methyltransferase, putative	0.3151	1	1
Brugia malayi	hypothetical protein	0.0039	0.0055	0.0055
Brugia malayi	G-protein coupled receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	glutathione reductase	0.0043	0.0069	0.0069
Schistosoma mansoni	amine GPCR	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	neuropeptide receptor	0.0039	0.0055	0.0055
Echinococcus granulosus	g-protein coupled receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	allatostatin A receptor	0.0039	0.0055	0.0055
Echinococcus granulosus	g protein coupled receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	chromobox protein	0.0081	0.0192	0.0192
Echinococcus multilocularis	G protein coupled receptor 139	0.0039	0.0055	0.0055
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0039	0.0055	0.0055
Trichomonas vaginalis	chromobox protein, putative	0.0081	0.0192	0.0192
Echinococcus granulosus	geminin	0.0198	0.0565	0.0565
Onchocerca volvulus		0.0036	0.0046	0.1137
Loa Loa (eye worm)	MH2 domain-containing protein	0.0136	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Brugia malayi	Thioredoxin reductase	0.0043	0.0069	0.0069
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0055	0.0055
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0039	0.0055	0.0055
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0039	0.0055	0.0055
Plasmodium falciparum	thioredoxin reductase	0.0043	0.0069	0.0069
Giardia lamblia	PHD finger protein 15	0.0034	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	growth hormone secretagogue receptor	0.0039	0.0055	0.0055
Plasmodium vivax	glutathione reductase, putative	0.0043	0.0069	0.0069
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.0055	0.0055
Mycobacterium ulcerans	hypothetical protein	0.1376	0.4327	1
Brugia malayi	Dopamine receptor protein 2	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Brugia malayi	Heterochromatin protein 1	0.0081	0.0192	0.0192
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Brugia malayi	sulfakinin receptor protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0039	0.0055	0.0055
Brugia malayi	putative neuropeptide receptor NPR1	0.0039	0.0055	0.0055
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0078	0.0078
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0112	0.0288	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus granulosus	thioredoxin glutathione reductase	0.0044	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	thioredoxin reductase	0.0043	0.0069	0.0069
Onchocerca volvulus		0.0039	0.0055	0.3006
Echinococcus granulosus	fmrfamide receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Brugia malayi	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus multilocularis	dro:myosuppressin receptor	0.0039	0.0055	0.0055
Echinococcus granulosus	chromobox protein 1	0.0081	0.0192	0.0192
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus granulosus	lysine specific demethylase 5A	0.0041	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0039	0.0055	0.0055
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.3151	1	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0112	0.0288	0.0288
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0046	0.0046
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0039	0.0055	0.0055
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0098	0.0246	0.0568
Plasmodium vivax	thioredoxin reductase, putative	0.0043	0.0069	0.0069
Echinococcus granulosus	neuropeptide receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	amine GPCR	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.0055	0.0055
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	chromobox protein	0.0081	0.0192	0.0192
Echinococcus granulosus	g protein coupled receptor	0.0039	0.0055	0.0055
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0109	0.0281	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	opsin-like receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	orexin receptor type 2	0.0039	0.0055	0.0055
Echinococcus multilocularis	sex peptide receptor	0.0039	0.0055	0.0055
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0043	0.0069	0.016
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Trypanosoma brucei	prenyl protein specific carboxyl methyltransferase	0.3151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0039	0.0055	0.0055
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0039	0.0055	0.0055
Brugia malayi	MH2 domain containing protein	0.0136	0.0366	0.0366
Schistosoma mansoni	histamine h1 receptor	0.0039	0.0055	0.0055
Mycobacterium tuberculosis	Probable reductase	0.0098	0.0246	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Schistosoma mansoni	protein-s-isoprenylcysteine o-methyltransferase	0.3151	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Echinococcus multilocularis	neuropeptide s receptor	0.0039	0.0055	0.0055
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0046	0.0078	0.7695
Echinococcus granulosus	sex peptide receptor	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0039	0.0055	0.0055
Trichomonas vaginalis	chromobox protein, putative	0.0081	0.0192	0.0192
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.0055	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0041	0.0041
Brugia malayi	chromobox protein homolog 3	0.0046	0.0078	0.0078
Echinococcus granulosus	allatostatin A receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	jumonji domain containing protein	0.0089	0.0215	0.0215
Echinococcus multilocularis	serotonin receptor	0.0039	0.0055	0.0055
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0039	0.0055	0.0055
Plasmodium vivax	protein-S-isoprenylcysteine O-methyltransferase, putative	0.3151	1	1
Schistosoma mansoni	myosin xvIII	0.0039	0.0055	0.0055
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.1376	0.4327	1
Echinococcus granulosus	G protein coupled receptor 139	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Echinococcus granulosus	chromobox protein 1	0.0081	0.0192	0.0192
Brugia malayi	Dopamine receptor protein 1	0.0039	0.0055	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.0055	0.0055
Schistosoma mansoni	amine GPCR	0.0039	0.0055	0.0055
Echinococcus granulosus	biogenic amine 5HT receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0039	0.0055	0.0055
Loa Loa (eye worm)	jmjC domain-containing protein	0.0041	0.0063	0.0063
Echinococcus granulosus	biogenic amine 5HT receptor	0.0039	0.0055	0.0055
Schistosoma mansoni	adenoreceptor	0.0039	0.0055	0.0055
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.0055	0.0055
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.0055	0.0055
Echinococcus granulosus	7TM GPCR rhodopsin	0.0039	0.0055	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0078	0.0078
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0039	0.0055	0.0055
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0049	0.0089	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0055	0.0055
Onchocerca volvulus		0.0039	0.0055	0.3006

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.2355 uM	DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro.	ChEMBL.	No reference
IC90 (functional)	= 0.67 uM	DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma cruzi	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1863175

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1052235