Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0125 | 0.387 | 0.6084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0232 | 0.0232 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.1295 | 0.1779 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0107 | 0.3261 | 0.3261 |
Trichomonas vaginalis | glutaminase, putative | 0.0299 | 1 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0021 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0675 | 0.0675 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.1295 | 0.1295 |
Loa Loa (eye worm) | glutaminase | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.3261 | 0.3261 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0675 | 0.0741 |
Brugia malayi | nuclear hormone receptor | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0453 | 0.0453 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.4624 | 0.4496 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0435 | 0.0435 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0453 | 0.0369 |
Schistosoma mansoni | lamin | 0.0028 | 0.0453 | 0.0226 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0675 | 0.0741 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.1295 | 0.1779 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.387 | 0.3724 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0021 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0232 | 0.0232 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0453 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0021 | 0.0232 | 0.0232 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0675 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0232 | 0.0232 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.2064 | 0.1875 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0232 | 0.0232 |
Echinococcus granulosus | geminin | 0.0191 | 0.6211 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0453 | 0.0369 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0107 | 0.3261 | 0.3261 |
Echinococcus multilocularis | geminin | 0.0191 | 0.6211 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1295 | 0.1089 |
Brugia malayi | steroid hormone receptor | 0.0021 | 0.0232 | 0.0232 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0453 | 0.0226 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0021 | 0.0232 | 0.0232 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0675 | 0.0453 |
Brugia malayi | ecdysteroid receptor | 0.0021 | 0.0232 | 0.0232 |
Onchocerca volvulus | 0.0028 | 0.0453 | 1 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0232 | 0.0232 |
Schistosoma mansoni | lamin | 0.0028 | 0.0453 | 0.0226 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0232 | 0.0232 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0675 | 0.0741 |
Schistosoma mansoni | glutaminase | 0.0299 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0675 | 0.0675 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.6211 | 0.6121 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1295 | 0.1089 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0675 | 0.0741 |
Loa Loa (eye worm) | glutaminase 2 | 0.0299 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.2064 | 0.2064 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0125 | 0.387 | 0.6084 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0453 | 0.0453 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0021 | 0.0232 | 0.0232 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0675 | 0.0453 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0021 | 0.0232 | 0.0232 |
Onchocerca volvulus | 0.0028 | 0.0453 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0021 | 0.0232 | 0.0232 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0453 | 0.0369 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.6211 | 0.6121 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0146 | 0.4624 | 0.7346 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.1295 | 0.1295 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0232 | 0.0232 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1295 | 0.1089 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0107 | 0.3261 | 0.3261 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0675 | 0.0741 |
Mycobacterium ulcerans | glutaminase | 0.0299 | 1 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0675 | 0.0741 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0021 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0021 | 0.0232 | 0.0232 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.1295 | 0.1779 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0021 | 0.0232 | 0.0232 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0675 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0453 | 0.0453 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0021 | 0.0232 | 0.0232 |
Echinococcus granulosus | lamin | 0.0028 | 0.0453 | 0.0369 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0453 | 0.0369 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.4624 | 0.4496 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2064 | 0.2064 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.1295 | 0.1779 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0675 | 0.0453 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 11 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.