Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable reductase | 0.0114 | 0.216 | 0.3563 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0196 | 0.0196 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.0483 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0196 | 0.0398 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0061 | 0.0762 | 0.6635 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0196 | 0.0398 |
Brugia malayi | bZIP transcription factor family protein | 0.0167 | 0.3552 | 0.7196 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0114 | 0.216 | 0.3563 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0196 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0196 | 0.0398 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0114 | 0.216 | 0.3563 |
Leishmania major | trypanothione reductase | 0.005 | 0.0483 | 0.336 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.1049 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0196 | 0.0196 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0196 | 0.0398 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0167 | 0.3552 | 0.3552 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0196 | 0.0398 |
Brugia malayi | Pre-SET motif family protein | 0.022 | 0.4936 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.0483 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.0483 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.0483 | 0.336 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.1049 | 0.1049 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0.0483 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0167 | 0.3552 | 0.3552 |
Echinococcus granulosus | geminin | 0.0184 | 0.3987 | 0.3987 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0762 | 0.0762 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.0259 | 0.0259 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0127 | 0.2493 | 0.4167 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0061 | 0.0762 | 0.1543 |
Schistosoma mansoni | jun-related protein | 0.0136 | 0.2732 | 0.2732 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.0483 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.1049 | 0.1049 |
Loa Loa (eye worm) | thioredoxin reductase | 0.005 | 0.0483 | 0.0978 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.0196 | 0.4066 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.0259 | 0.0259 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0114 | 0.216 | 0.3563 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0196 | 0.0398 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0072 | 0.1049 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0127 | 0.2493 | 1 |
Brugia malayi | hypothetical protein | 0.0131 | 0.2612 | 0.5291 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.0483 | 0.336 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0413 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.1049 | 0.1049 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0196 | 0.0398 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0061 | 0.0762 | 0.1026 |
Onchocerca volvulus | 0.0039 | 0.0196 | 0.0342 | |
Onchocerca volvulus | 0.0131 | 0.2612 | 0.4556 | |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0072 | 0.1049 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0196 | 0.0398 |
Schistosoma mansoni | hypothetical protein | 0.0136 | 0.2732 | 0.2732 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0114 | 0.216 | 0.3563 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.3987 | 0.3987 |
Loa Loa (eye worm) | glutathione reductase | 0.005 | 0.0483 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3432 | 0.6953 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0057 | 0.0655 | 0.1327 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0127 | 0.2493 | 0.4167 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.022 | 0.4936 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0196 | 0.0196 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.0483 | 0.0483 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0061 | 0.0762 | 0.0762 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.1049 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0196 | 0.0398 |
Onchocerca volvulus | 0.0039 | 0.0196 | 0.0342 | |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.3987 | 0.3987 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.0483 | 0.0978 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0413 | 1 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.025 | 0.5732 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.0483 | 0.0483 |
Echinococcus granulosus | jun protein | 0.0167 | 0.3552 | 0.3552 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0114 | 0.216 | 0.3563 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.0762 | 1 |
Echinococcus multilocularis | geminin | 0.0184 | 0.3987 | 0.3987 |
Echinococcus multilocularis | jun protein | 0.0167 | 0.3552 | 0.3552 |
Brugia malayi | glutathione reductase | 0.005 | 0.0483 | 0.0978 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0072 | 0.1049 | 0.2125 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0249 | 0.5708 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0061 | 0.0762 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.1049 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.0196 | 0.4066 |
Onchocerca volvulus | 0.025 | 0.5732 | 1 | |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0127 | 0.2493 | 0.4167 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0072 | 0.1049 | 0.2125 |
Onchocerca volvulus | 0.0039 | 0.0196 | 0.0342 | |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0061 | 0.0762 | 0.0762 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0196 | 0.0398 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0196 | 0.0196 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.005 | 0.0483 | 0.052 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0114 | 0.216 | 0.8549 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0196 | 0.0398 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | > 30 uM | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose | ChEMBL. | 19427223 |
EC50 (binding) | > 30 uM | Activation of flag-tagged human recombinant liver glucokinase expressed in Escherichia coli by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose | ChEMBL. | 19427223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.