TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 238.292 | Formula: C12H18FN3O
H donors: 1 H acceptors: 2 LogP: 1.33 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCNC(=O)c1ccc(nc1)[18F])CC
InChi: 1S/C12H18FN3O/c1-3-16(4-2)8-7-14-12(17)10-5-6-11(13)15-9-10/h5-6,9H,3-4,7-8H2,1-2H3,(H,14,17)/i13-1
InChiKey: KDJDPOPMAGYJLH-HSGWXFLFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable DNA polymerase I PolA	0.0178	0.0472	1
Trypanosoma cruzi	mitochondrial DNA polymerase I protein A, putative	0.0052	0.0106	0.0394
Leishmania major	cathepsin L-like protease	0.0022	0.0021	0.004
Echinococcus granulosus	tissue type plasminogen activator	0.0018	0.001	0.1496
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0021	0.1968
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0022	0.0021	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.0021	0.0021
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Schistosoma mansoni	hypothetical protein	0.0038	0.0068	0.081
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0022	0.0022	0.1987
Schistosoma mansoni	hypothetical protein	0.0038	0.0068	0.081
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0021	0.1968
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0022	0.0258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Plasmodium falciparum	5'-3' exonuclease, N-terminal resolvase-like domain, putative	0.0127	0.0323	0.1163
Plasmodium vivax	telomerase reverse transcriptase, putative	0.0951	0.2701	1
Loa Loa (eye worm)	ctsf protein	0.0022	0.0021	0.0251
Onchocerca volvulus		0.0022	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0021	0.0078
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Toxoplasma gondii	DNA polymerase I domain-containing protein	0.0052	0.0106	0.0358
Chlamydia trachomatis	DNA polymerase I	0.0178	0.0472	0.5
Brugia malayi	Trypsin family protein	0.0022	0.0022	0.003
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Trypanosoma brucei	telomerase reverse transcriptase	0.0951	0.2701	1
Onchocerca volvulus		0.0022	0.0022	0.0022
Leishmania major	cathepsin L-like protease	0.0022	0.0021	0.004
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0022	0.0022	0.0258
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0022	0.0021	0.3104
Toxoplasma gondii	RNA-directed DNA polymerase	0.0951	0.2701	1
Leishmania major	cathepsin L-like protease	0.0022	0.0021	0.004
Giardia lamblia	Telomerase catalytic subunit	0.0951	0.2701	0.5
Onchocerca volvulus		0.0022	0.0021	0.0021
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0304	0.0833	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Loa Loa (eye worm)	trypsin family protein	0.0022	0.0022	0.0258
Brugia malayi	Trypsin-like protease protein 5	0.0022	0.0022	0.003
Onchocerca volvulus		0.0018	0.001	0.001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Entamoeba histolytica	DNA-directed DNA polymerase, putative	0.0052	0.0106	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0022	0.0021	0.004
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0022	0.0258
Echinococcus granulosus	cathepsin l1	0.0022	0.0021	0.3104
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0304	0.0833	1
Onchocerca volvulus		0.0022	0.0022	0.0022
Mycobacterium ulcerans	5'-3' exonuclease	0.0127	0.0323	0.6694
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0021	0.0029
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Echinococcus granulosus	transmembrane protease serine 3	0.0022	0.0022	0.3186
Onchocerca volvulus		0.0281	0.077	0.077
Echinococcus granulosus	Mastin	0.0022	0.0022	0.3186
Trypanosoma cruzi	mitochondrial structure specific endonuclease I (SSE-1), putative	0.0127	0.0323	0.1196
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0021	0.1968
Brugia malayi	Trypsin family protein	0.0022	0.0022	0.003
Plasmodium falciparum	telomerase reverse transcriptase	0.0951	0.2701	1
Leishmania major	cathepsin L-like protease	0.0022	0.0021	0.004
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0021	0.0251
Leishmania major	mitochondrial DNA polymerase I protein A, putative	0.0052	0.0106	0.0358
Plasmodium falciparum	plastid replication-repair enzyme	0.0052	0.0106	0.0358
Loa Loa (eye worm)	fibroinase	0.0022	0.0021	0.0251
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0021	0.1968
Echinococcus multilocularis	enteropeptidase	0.0022	0.0022	0.1987
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.0021	0.1891
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0022	0.0022	0.0258
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.0021	0.1891
Echinococcus granulosus	twinkle protein mitochondrial	0.0038	0.0068	1
Entamoeba histolytica	cysteine protease, putative	0.0022	0.0021	0.1968
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0021	0.0029
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0022	0.0022	0.3186
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0022	0.0022	0.0258
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0022	0.0022	0.0258
Echinococcus multilocularis	twinkle protein, mitochondrial	0.0038	0.0068	1
Mycobacterium leprae	PROBABLE DNA POLYMERASE I POLA	0.0178	0.0472	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0018	0.001	0.0121
Schistosoma mansoni	hypothetical protein	0.0022	0.0022	0.0258
Onchocerca volvulus		0.0022	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0304	0.0833	1
Schistosoma mansoni	hypothetical protein	0.0018	0.001	0.0121
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0021	0.1968
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Echinococcus multilocularis	transmembrane protease serine 3	0.0022	0.0022	0.1987
Echinococcus multilocularis	cysteine protease	0.0022	0.0021	0.1891
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0022	0.0022	0.003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0021	0.1968
Leishmania major	cathepsin L-like protease	0.0022	0.0021	0.004
Onchocerca volvulus		0.0022	0.0021	0.0021
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0022	0.0021	0.004
Leishmania major	cysteine peptidase A (CPA)	0.0022	0.0021	0.004
Loa Loa (eye worm)	hypothetical protein	0.0304	0.0833	1
Brugia malayi	Protein kinase domain containing protein	0.0018	0.001	0.0014
Brugia malayi	Kringle domain containing protein	0.0018	0.001	0.0014
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0021	0.1968
Schistosoma mansoni	hypothetical protein	0.0022	0.0022	0.0258
Onchocerca volvulus	Cathepsin F homolog	0.0022	0.0021	0.0021
Onchocerca volvulus	Twinkle protein, mitochondrial homolog	0.0038	0.0068	0.0068
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.0021	0.0029
Treponema pallidum	DNA polymerase I (polA)	0.0178	0.0472	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Echinococcus multilocularis	glycoprotein Antigen 5	0.0022	0.0022	0.1987
Trypanosoma cruzi	cruzipain precursor, putative	0.0022	0.0021	0.0078
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0022	0.0022	0.3186
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0022	0.0022	0.1987
Echinococcus multilocularis	Mastin	0.0022	0.0022	0.1987
Onchocerca volvulus		0.0022	0.0021	0.0021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Trypanosoma cruzi	mitochondrial DNA polymerase I protein A, putative	0.0052	0.0106	0.0394
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0021	0.1968
Trypanosoma cruzi	mitochondrial structure specific endonuclease I (SSE-1), putative	0.0127	0.0323	0.1196
Echinococcus granulosus	glycoprotein Antigen 5	0.0022	0.0022	0.3186
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0021	0.0029
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0021	0.0251
Brugia malayi	Trypsin family protein	0.0304	0.0833	0.1149
Plasmodium vivax	5'-3' exonuclease, N-terminal resolvase-like domain, putative	0.0127	0.0323	0.1163
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0951	0.2701	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0021	0.0078
Brugia malayi	Telomerase reverse transcriptase	0.253	0.7257	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0022	0.0021	0.1891
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0021	0.1968
Leishmania major	cathepsin L-like protease	0.0022	0.0021	0.004
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.0951	0.2701	1
Leishmania major	cathepsin L-like protease	0.0022	0.0021	0.004
Leishmania major	telomerase reverse transcriptase, putative	0.0951	0.2701	1
Onchocerca volvulus		0.0022	0.0021	0.0021
Mycobacterium ulcerans	DNA polymerase I	0.0178	0.0472	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Trypanosoma brucei	mitochondrial DNA polymerase I protein A, putative	0.0052	0.0106	0.0319
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0021	0.0078
Trypanosoma cruzi	cysteine peptidase, putative	0.0022	0.0021	0.0078
Loa Loa (eye worm)	twinkle helicase	0.0038	0.0068	0.081
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	0.0021	0.0251
Trypanosoma brucei	mitochondrial structure specific endonuclease I (SSE-1), putative	0.0127	0.0323	0.1127
Brugia malayi	Trypsin family protein	0.0022	0.0022	0.003
Loa Loa (eye worm)	TK/ROR protein kinase	0.0018	0.001	0.0121
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0021	0.0029
Wolbachia endosymbiont of Brugia malayi	DNA polymerase I	0.0178	0.0472	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0022	0.0258
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0022	0.0021	0.1891
Schistosoma mansoni	cercarial elastase (S01 family)	0.0022	0.0022	0.0258
Entamoeba histolytica	cysteine proteinase, putative	0.0022	0.0021	0.1968
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0022	0.0021	0.3104
Onchocerca volvulus		0.0022	0.0021	0.0021
Plasmodium vivax	plastid replication-repair enzyme, putative	0.0052	0.0106	0.0358
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.0021	0.1968
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Onchocerca volvulus		0.0022	0.0022	0.0022
Onchocerca volvulus		0.0304	0.0833	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0106	0.1277
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.001	0.0037
Plasmodium vivax	vivapain-2	0.0022	0.0021	0.004
Leishmania major	cathepsin L-like protease	0.0022	0.0021	0.004
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0022	0.0022	0.0258
Toxoplasma gondii	helicase, putative	0.0052	0.0106	0.0358
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0021	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0022	0.0258
Leishmania major	mitochondrial structure specific endonuclease I (SSE-1), putative	0.0127	0.0323	0.1163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968
Plasmodium vivax	vivapain-2	0.0022	0.0021	0.004
Toxoplasma gondii	5'-3' exonuclease, N-terminal resolvase family domain-containing protein	0.0062	0.0137	0.047
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0022	0.0022	0.0258
Brugia malayi	hypothetical protein	0.0022	0.0022	0.003
Toxoplasma gondii	cathepsin CPL	0.0022	0.0021	0.004
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0021	0.0251
Brugia malayi	DNA polymerase I family protein	0.0052	0.0106	0.0147
Echinococcus multilocularis	cysteine protease	0.0022	0.0021	0.1891
Echinococcus granulosus	enteropeptidase	0.0022	0.0022	0.3186
Loa Loa (eye worm)	cysteine protease	0.0022	0.0021	0.0251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0022	0.0021	0.1968
Schistosoma mansoni	DNA polymerase I	0.0052	0.0106	0.1277
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0022	0.0021	0.0251
Onchocerca volvulus		0.0022	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0022	0.0258
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0021	0.1968
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0021	0.0029
Onchocerca volvulus		0.0022	0.0021	0.0021
Trichomonas vaginalis	DNA polymerase I, putative	0.0052	0.0106	1
Trypanosoma brucei	mitochondrial DNA polymerase I protein A, putative	0.0052	0.0106	0.0319
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0021	0.1968

Activities

Activity type	Activity value	Assay description	Source	Reference
Drug uptake (ADMET)	= 0.07 %	Biodistribution in lung of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 6 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.13 %	Biodistribution in intestine of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 6 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.17 %	Biodistribution in thyroid of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 6 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.19 %	Biodistribution in stomach of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 6 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.25 %	Biodistribution in lung of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 3 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.38 %	Biodistribution in lung of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 2 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.47 %	Biodistribution in spleen of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 6 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.49 %	Biodistribution in thyroid of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 3 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.52 %	Biodistribution in bone of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 6 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.54 %	Biodistribution in intestine of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 3 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.58 %	Biodistribution in bone of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 2 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.61 %	Biodistribution in thyroid of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 2 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.62 %	Biodistribution in bone of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 3 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.71 %	Biodistribution in intestine of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 2 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.83 %	Biodistribution in stomach of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 3 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 0.89 %	Biodistribution in spleen of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 3 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 1.4 %	Biodistribution in bone of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 1 hr by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 1.5 %	Biodistribution in stomach of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 2 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 1.6 %	Biodistribution in lung of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 1 hr by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 1.8 %	Biodistribution in spleen of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 2 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 2.1 %	Biodistribution in bone of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.5 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 2.1 %	Biodistribution in intestine of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 1 hr by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 2.4 %	Biodistribution in spleen of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 1 hr by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 2.5 %	Biodistribution in thyroid of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.5 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 2.9 %	Biodistribution in lung of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.5 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 3.3 %	Biodistribution in thyroid of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 1 hr by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 3.4 %	Biodistribution in stomach of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 1 hr by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 3.5 %	Biodistribution in bone of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.25 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 3.9 %	Biodistribution in intestine of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.5 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 5.4 %	Biodistribution in intestine of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.25 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 5.5 %	Biodistribution in thyroid of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.25 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 5.6 %	Biodistribution in lung of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.25 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 6.6 %	Biodistribution in stomach of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.5 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 7.2 %	Biodistribution in spleen of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.5 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 8.6 %	Biodistribution in spleen of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.25 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 9.4 %	Biodistribution in stomach of mouse B16F0 cells implanted C57BL/6J mouse assessed per gram of tissue at 0.4 to 5.5 MBq, iv after 0.25 hrs by gamma counter	ChEMBL.	19691348
Drug uptake (ADMET)	= 32.23 % ID/g	Biodistribution in eye of C57BL/6 mouse xenografted with mouse B16F10 cells at 3.7 MBq, iv after 2 hrs by gamma-scintillation counting analysis	ChEMBL.	23301672

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL561174

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1053131