TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 352.879 | Formula: C17H21ClN2O2S
H donors: 1 H acceptors: 1 LogP: 4.63 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(CN1CCCCC1)CO/N=C(/c1cc2c(s1)cccc2)\Cl
InChi: 1S/C17H21ClN2O2S/c18-17(16-10-13-6-2-3-7-15(13)23-16)19-22-12-14(21)11-20-8-4-1-5-9-20/h2-3,6-7,10,14,21H,1,4-5,8-9,11-12H2/b19-17-
InChiKey: JVFLMZQNUVLUAO-ZPHPHTNESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	insulin receptor	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK protein kinase	0.0013	0.0428	0.0428
Brugia malayi	Tensin	0.0047	0.7313	0.7313
Brugia malayi	SH2 domain containing protein	0.0047	0.7313	0.7313
Schistosoma mansoni	tyrosine kinase	0.0061	1	1
Echinococcus multilocularis		0.0047	0.7313	0.7313
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0013	0.0428	0.0428
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0047	0.7313	0.7313
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0061	1	1
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0047	0.7313	0.7313
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/ACK protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/ROR protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine kinase	0.0061	1	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0061	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	1	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0013	0.0428	0.0428
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0013	0.0428	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0047	0.7313	0.7313
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0061	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.5026	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0047	0.7313	0.7313
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Onchocerca volvulus		0.0061	1	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	SH2 motif	0.0047	0.7313	0.7313
Loa Loa (eye worm)	TK protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	1	1
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.6255	0.6255
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK protein kinase	0.0061	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0047	0.7313	0.7313
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0047	0.7313	0.7313
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0061	1	1
Loa Loa (eye worm)	STAT protein	0.0047	0.7313	0.7313
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0047	0.7313	0.7313
Brugia malayi	integrin-linked kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	SH2A	0.0047	0.7313	0.7313
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	integrin linked protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0013	0.0428	0.0428
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	suppressor of cytokine signaling	0.0047	0.7313	0.7313
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0061	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0428	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.6255	0.6255
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0013	0.0428	0.0428
Brugia malayi	SH2 domain containing protein	0.0047	0.7313	0.7313
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0061	1	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Brugia malayi	SH2 domain containing protein	0.0047	0.7313	0.7313
Echinococcus multilocularis	tyrosine protein kinase csk	0.0013	0.0428	0.0428
Echinococcus multilocularis	signal transduction protein lnk realted	0.0047	0.7313	0.7313
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0013	0.0428	0.0428
Brugia malayi	Variant SH3 domain containing protein	0.0047	0.7313	0.7313
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0061	1	1
Echinococcus granulosus	SHC transforming protein 3	0.0047	0.7313	0.7313
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0047	0.7313	0.7192
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	growth factor receptor bound protein 2	0.0047	0.7313	0.7313
Loa Loa (eye worm)	TK/FAK protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0061	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0047	0.7313	0.7313
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0013	0.0428	0.0428
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	SHC transforming protein 3	0.0047	0.7313	0.7313
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	1	1
Giardia lamblia	Protein 21.1	0.0013	0.0428	0.5
Plasmodium falciparum	protein kinase, putative	0.0013	0.0428	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0013	0.0428	0.0428
Echinococcus multilocularis	epidermal growth factor receptor	0.0013	0.0428	0.0428
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0039	0.5539	0.5539
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0047	0.7313	0.7313
Schistosoma mansoni	tensin-related	0.0047	0.7313	0.7313
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	tensin	0.0047	0.7313	0.7313
Brugia malayi	hypothetical protein	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0013	0.0428	0.0428
Schistosoma mansoni	hypothetical protein	0.0013	0.0428	0.0428
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0061	1	1
Plasmodium falciparum	protein kinase, putative	0.0013	0.0428	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0047	0.7313	0.7313
Brugia malayi	Receptor family ligand binding region containing protein	0.0013	0.0428	0.0428
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0013	0.0428	0.0428
Plasmodium falciparum	tyrosine kinase-like protein	0.0013	0.0428	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0013	0.0428	0.0428
Echinococcus granulosus	protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/ALK protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0013	0.0428	0.0428
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0013	0.0428	0.5
Schistosoma mansoni	tensin	0.0047	0.7313	0.7313
Onchocerca volvulus		0.0047	0.7313	0.7192
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0047	0.7313	0.7313
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0047	0.7313	0.7313
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase csk	0.0013	0.0428	0.0428
Echinococcus multilocularis	SH2 motif	0.0047	0.7313	0.7313
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0047	0.7313	0.7313
Echinococcus multilocularis	epidermal growth factor receptor	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0061	1	1
Brugia malayi	Raf kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	protein tyrosine kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0061	1	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0047	0.7313	0.7313
Brugia malayi	SH2 domain containing protein	0.0061	1	1
Echinococcus granulosus	c src tyrosine kinase	0.0061	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0013	0.0428	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0047	0.7313	0.7313
Loa Loa (eye worm)	TK protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0013	0.0428	0.0428
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0013	0.0428	0.0428
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0047	0.7313	0.7313
Schistosoma mansoni	serine/threonine RGC	0.0013	0.0428	0.0428
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0013	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Schistosoma mansoni	adapter molecule crk	0.0047	0.7313	0.7313
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/ABL protein kinase	0.0061	1	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	c src tyrosine kinase	0.0061	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0047	0.7313	0.7313
Loa Loa (eye worm)	hypothetical protein	0.0061	1	1
Brugia malayi	SRC-1	0.0061	1	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0013	0.0428	0.0428
Echinococcus granulosus	kinase suppressor of Ras 1	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0013	0.0428	0.0428
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0047	0.7313	0.7192
Echinococcus granulosus	integrin linked protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Plasmodium falciparum	protein kinase, putative	0.0013	0.0428	0.5
Echinococcus multilocularis	protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0061	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	1	1
Echinococcus multilocularis	SH2 motif	0.0047	0.7313	0.7313
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0061	1	1
Brugia malayi	SH2 domain containing protein	0.0047	0.7313	0.7313
Trypanosoma brucei	protein kinase, putative	0.0013	0.0428	0.5
Loa Loa (eye worm)	TK/Met protein kinase	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus granulosus	receptor type guanylyl cyclase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0047	0.7313	0.7313
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	1	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus granulosus	N chimaerin	0.0047	0.7313	0.7313
Brugia malayi	Variant SH3 domain containing protein	0.0047	0.7313	0.7313
Echinococcus granulosus	natriuretic peptide receptor 1	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Brugia malayi	RhoGAP domain containing protein	0.0047	0.7313	0.7313
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase csk	0.0013	0.0428	0.0428
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0047	0.7313	0.7313
Echinococcus multilocularis	tyrosine protein kinase csk	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	1	1
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0047	0.7313	0.7313
Brugia malayi	Protein kinase domain containing protein	0.0061	1	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0061	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.0047	0.7313	0.7313
Schistosoma mansoni	suppressor of cytokine signaling	0.0047	0.7313	0.7313
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0047	0.7313	0.7313
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0428	0.0428
Toxoplasma gondii	STE kinase	0.0013	0.0428	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0047	0.7313	0.7313
Trypanosoma cruzi	protein kinase, putative	0.0013	0.0428	0.5
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0061	1	1
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	1	1
Plasmodium vivax	protein kinase, putative	0.0013	0.0428	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0061	1	1
Echinococcus granulosus	tyrosine kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0013	0.0428	0.0428
Brugia malayi	SH2 domain containing protein	0.0047	0.7313	0.7313
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0428	0.0428
Entamoeba histolytica	SH2 domain containing protein	0.0047	0.7313	0.7192
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0039	0.5539	0.5539
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0013	0.0428	0.0428
Brugia malayi	Variant SH3 domain containing protein	0.0047	0.7313	0.7313
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	1	1
Echinococcus multilocularis	tensin	0.0047	0.7313	0.7313
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0047	0.7313	0.7313
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0047	0.7313	0.7313
Brugia malayi	hypothetical protein	0.0047	0.7313	0.7313
Echinococcus multilocularis	tyrosine kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Onchocerca volvulus		0.0061	1	1
Echinococcus multilocularis	activin receptor type	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase Srms	0.0061	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0013	0.0428	0.0428
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine kinase	0.0061	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0061	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase HCK	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0047	0.7313	0.7313
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0039	0.5539	0.5539
Loa Loa (eye worm)	TK/DDR protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/EPH protein kinase	0.0013	0.0428	0.0428
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0013	0.0428	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0061	1	1
Schistosoma mansoni	GTPase activating protein	0.0047	0.7313	0.7313
Onchocerca volvulus		0.0061	1	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0047	0.7313	0.7313
Onchocerca volvulus		0.0047	0.7313	0.7192
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Toxoplasma gondii	protein kinase	0.0013	0.0428	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0013	0.0428	0.0428
Trypanosoma cruzi	protein kinase, putative	0.0013	0.0428	0.5
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Brugia malayi	protein-tyrosine kinase	0.0061	1	1
Schistosoma mansoni	tyrosine kinase	0.0061	1	1
Schistosoma mansoni	shc transforming protein	0.0047	0.7313	0.7313
Brugia malayi	Tyrosine-protein kinase PR2	0.0013	0.0428	0.0428
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0039	0.5539	0.5539
Brugia malayi	Protein kinase domain containing protein	0.0061	1	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	hypothetical protein	0.0047	0.7313	0.7313
Echinococcus granulosus	ephrin type A receptor 4 A	0.0013	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Schistosoma mansoni	hypothetical protein	0.0047	0.7313	0.7313
Echinococcus granulosus	hypothetical protein	0.0047	0.7313	0.7313
Plasmodium falciparum	tyrosine kinase-like protein	0.0013	0.0428	0.5
Schistosoma mansoni	tensin	0.0047	0.7313	0.7313
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0061	1	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0013	0.0428	0.0428
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0061	1	1
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0013	0.0428	0.0428
Echinococcus granulosus	activated cdc42 kinase 1	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0047	0.7313	0.7313
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0013	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Brugia malayi	SH2 domain containing protein	0.0061	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	protein kinase	0.0013	0.0428	0.0428
Leishmania major	protein kinase, putative	0.0013	0.0428	0.5
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Brugia malayi	Tyrosine-protein kinase abl-1	0.0061	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0428	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	1	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.4509	0.4509
Leishmania major	hypothetical protein, conserved	0.0013	0.0428	0.5
Echinococcus multilocularis	NCK adaptor protein	0.0047	0.7313	0.7313
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	SH2 domain containing protein 7	0.0047	0.7313	0.7313
Brugia malayi	hypothetical protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0013	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0061	1	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0013	0.0428	0.0428
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.5026	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0013	0.0428	0.0428
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0061	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0013	0.0428	0.5
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0013	0.0428	0.0428
Onchocerca volvulus		0.0047	0.7313	0.7192
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase shark	0.0061	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0013	0.0428	0.0428
Echinococcus granulosus	tensin	0.0047	0.7313	0.7313
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus granulosus	activin receptor type	0.0013	0.0428	0.0428
Giardia lamblia	Kinase, NEK	0.0013	0.0428	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	vav2	0.0047	0.7313	0.7313
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0047	0.7313	0.7313
Echinococcus multilocularis	protein tyrosine kinase	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0061	1	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0013	0.0428	0.0428
Schistosoma mansoni	tensin-related	0.0047	0.7313	0.7313
Loa Loa (eye worm)	SRC-1	0.0061	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0013	0.0428	0.0428
Echinococcus multilocularis	insulin receptor	0.0013	0.0428	0.0428
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0013	0.0428	0.0428
Schistosoma mansoni	ephrin receptor	0.0013	0.0428	0.0428
Loa Loa (eye worm)	SH2 domain-containing protein	0.0047	0.7313	0.7313
Echinococcus multilocularis	N chimaerin	0.0047	0.7313	0.7313
Giardia lamblia	Kinase	0.0013	0.0428	0.5
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	raf serine:threonine protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0061	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Echinococcus granulosus	expressed conserved protein	0.0047	0.7313	0.7313
Echinococcus granulosus	SH2 motif	0.0047	0.7313	0.7313
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0061	1	1
Schistosoma mansoni	ephrin receptor	0.0013	0.0428	0.0428
Onchocerca volvulus		0.0061	1	1
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0061	1	1
Schistosoma mansoni	protein tyrosine kinase	0.0013	0.0428	0.0428
Entamoeba histolytica	protein kinase, putative	0.0047	0.7313	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Echinococcus multilocularis	SH2 domain containing protein 7	0.0047	0.7313	0.7313
Echinococcus multilocularis	activated cdc42 kinase 1	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0013	0.0428	0.0428
Brugia malayi	Variant SH3 domain containing protein	0.0047	0.7313	0.7313
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine kinase	0.0061	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0013	0.0428	0.5
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0061	1	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0047	0.7313	0.7313
Schistosoma mansoni	tyrosine kinase	0.0061	1	1
Brugia malayi	C-terminal src kinase protein 1	0.0013	0.0428	0.0428
Onchocerca volvulus		0.0047	0.7313	0.7192
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0047	0.7313	0.7192
Trypanosoma brucei	Pseudokinase, putative	0.0013	0.0428	0.5
Brugia malayi	hypothetical protein	0.0061	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0013	0.0428	0.0428
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0013	0.0428	0.0428
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0047	0.7313	0.7313
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0047	0.7313	0.7313
Echinococcus granulosus	tyrosine protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0047	0.7313	0.7313
Leishmania major	protein kinase, putative	0.0013	0.0428	0.5
Brugia malayi	SH2 domain containing protein	0.0047	0.7313	0.7313
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0061	1	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0047	0.7313	0.7313
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0047	0.7313	0.7313
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Onchocerca volvulus		0.0047	0.7313	0.7192
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	FL cytokine receptor	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	epidermal growth factor receptor	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0061	1	1
Onchocerca volvulus		0.0047	0.7313	0.7192
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0047	0.7313	0.7313
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0061	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0047	0.7313	0.7313
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0013	0.0428	0.0428
Onchocerca volvulus		0.0061	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0061	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0013	0.0428	0.0428
Giardia lamblia	Kinase, NEK	0.0013	0.0428	0.5
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0013	0.0428	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0013	0.0428	0.0428
Schistosoma mansoni	signal transduction protein lnk-related	0.0047	0.7313	0.7313
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Loa Loa (eye worm)	TK protein kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0013	0.0428	0.0428
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0013	0.0428	0.0428
Schistosoma mansoni	tensin	0.0047	0.7313	0.7313
Echinococcus granulosus	signal transduction protein lnk realted	0.0047	0.7313	0.7313
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Echinococcus granulosus	tyrosine protein kinase shark	0.0061	1	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0047	0.7313	0.7313
Schistosoma mansoni	tyrosine protein kinase	0.0013	0.0428	0.0428
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	0.0428	0.0428
Brugia malayi	SH2 domain containing protein	0.0047	0.7313	0.7313
Loa Loa (eye worm)	TK/FER protein kinase	0.0061	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0061	1	1
Echinococcus granulosus	NCK adaptor protein	0.0047	0.7313	0.7313
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Brugia malayi	ephrin receptor 1 precursor	0.0013	0.0428	0.0428
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0013	0.0428	0.0428
Echinococcus multilocularis	heat shock protein 70	0.0013	0.0428	0.0428
Loa Loa (eye worm)	SH2 domain-containing protein	0.0047	0.7313	0.7313
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0428	0.5
Echinococcus multilocularis	SH2 motif	0.0047	0.7313	0.7313
Schistosoma mansoni	tyrosine kinase	0.0013	0.0428	0.0428
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	activated cdc42 kinase 1	0.0013	0.0428	0.0428
Schistosoma mansoni	protein kinase	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase csk	0.0013	0.0428	0.0428
Schistosoma mansoni	nck2/grb4	0.0047	0.7313	0.7313
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0428	0.0428
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0013	0.0428	0.0428
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0013	0.0428	0.0428
Onchocerca volvulus		0.0061	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0013	0.0428	0.5
Loa Loa (eye worm)	hypothetical protein	0.0047	0.7313	0.7313
Loa Loa (eye worm)	TK/FER protein kinase	0.0013	0.0428	0.0428

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Transcriptional activation of HSF1 in human HeLa cells assessed as granule formation treated 3 hrs before heat shock challenge by immunocytochemical staining	ChEMBL.	19398333
CC50 (ADMET)	= 67.7 uM	Cytotoxicity against human SK-N-SH cells by MTS assay	ChEMBL.	19398333
CC50 (ADMET)	> 80 uM	Cytotoxicity against human HeLa cells by MTS assay	ChEMBL.	19398333
EC50 (binding)		Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challenge measured after 2 hrs by immunocytochemical staining	ChEMBL.	19398333

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL559530

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1053181