Detailed information for compound 1053294

Basic information

Technical information
  • TDR Targets ID: 1053294
  • Name: (1E,4E)-1,5-bis(2-hydroxyphenyl)penta-1,4-die n-3-one
  • MW: 266.291 | Formula: C17H14O3
  • H donors: 2 H acceptors: 3 LogP: 3.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(/C=C/c1ccccc1O)/C=C/c1ccccc1O
  • InChi: 1S/C17H14O3/c18-15(11-9-13-5-1-3-7-16(13)19)12-10-14-6-2-4-8-17(14)20/h1-12,19-20H/b11-9+,12-10+
  • InChiKey: YNVAHBUBGBLIEY-WGDLNXRISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,5-Bis(2-hydroxyphenyl)penta-1,4-dien-3-one
  • 2150-52-9
  • Bis(2-hydroxybenzal)acetone
  • NSC86716

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens jun proto-oncogene No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi bZIP transcription factor family protein Get druggable targets OG5_131442 All targets in OG5_131442
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131442 All targets in OG5_131442
Echinococcus granulosus jun protein Get druggable targets OG5_131442 All targets in OG5_131442
Echinococcus multilocularis jun protein Get druggable targets OG5_131442 All targets in OG5_131442
Echinococcus granulosus Basic leucine zipper bZIP transcription factor Get druggable targets OG5_131442 All targets in OG5_131442
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor Get druggable targets OG5_131442 All targets in OG5_131442
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0029 0.1356 0.1387
Brugia malayi hypothetical protein 0.0029 0.1356 0.1356
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0032 0.1746 1
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0029 0.1356 0.1356
Schistosoma mansoni ephrin receptor 0.0029 0.1356 0.1752
Loa Loa (eye worm) protein kinase domain-containing protein 0.0029 0.1356 0.1387
Echinococcus multilocularis tyrosine protein kinase Srms 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0029 0.1356 0.1356
Echinococcus multilocularis epidermal growth factor receptor 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase ABL1 0.0029 0.1356 0.1356
Echinococcus multilocularis protein kinase 0.0029 0.1356 0.1356
Loa Loa (eye worm) RGC/RGC protein kinase 0.0029 0.1356 0.1387
Loa Loa (eye worm) TK/ACK protein kinase 0.0029 0.1356 0.1387
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0029 0.1356 0.5
Schistosoma mansoni protein kinase 0.0029 0.1356 0.1752
Echinococcus granulosus raf serine:threonine protein kinase 0.0029 0.1356 0.1356
Loa Loa (eye worm) serine/threonine protein kinase 0.0029 0.1356 0.1387
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Echinococcus multilocularis tyrosine protein kinase csk 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus granulosus retinal guanylyl cyclase 2 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK protein kinase 0.0029 0.1356 0.1387
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus multilocularis activated cdc42 kinase 1 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0029 0.1356 0.1356
Brugia malayi SRC-1 0.0029 0.1356 0.1356
Echinococcus granulosus Ankyrin 0.0018 0.0018 0.0018
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.1356 0.1356
Schistosoma mansoni protein tyrosine kinase 0.0029 0.1356 0.1752
Toxoplasma gondii STE kinase 0.0029 0.1356 0.5
Echinococcus multilocularis natriuretic peptide receptor 1 0.0029 0.1356 0.1356
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0029 0.1356 0.1752
Echinococcus granulosus tyrosine kinase 0.0029 0.1356 0.1356
Brugia malayi Furin-like cysteine rich region family protein 0.0029 0.1356 0.1356
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0029 0.1356 1
Echinococcus granulosus jun protein 0.0101 1 1
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0029 0.1356 0.1356
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0029 0.1356 0.1356
Entamoeba histolytica hypothetical protein 0.0032 0.1746 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0029 0.1356 0.1752
Echinococcus multilocularis kinase suppressor of Ras 1 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.1356 0.1356
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/CSK protein kinase 0.0029 0.1356 0.1387
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Brugia malayi Tyrosine-protein kinase abl-1 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/FAK protein kinase 0.0029 0.1356 0.1387
Entamoeba histolytica hypothetical protein 0.0032 0.1746 1
Schistosoma mansoni protein kinase 0.0029 0.1356 0.1752
Trichomonas vaginalis TKL family protein kinase 0.0029 0.1356 1
Loa Loa (eye worm) TK protein kinase 0.0029 0.1356 0.1387
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0029 0.1356 0.1387
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0029 0.1356 0.1356
Schistosoma mansoni protein kinase 0.0029 0.1373 0.1775
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/EPH protein kinase 0.0029 0.1356 0.1387
Brugia malayi SH2 domain containing protein 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Onchocerca volvulus 0.0029 0.1356 0.00000019786
Schistosoma mansoni hypothetical protein 0.0082 0.774 1
Trichomonas vaginalis TKL family protein kinase 0.0029 0.1356 1
Loa Loa (eye worm) TK protein kinase 0.0029 0.1356 0.1387
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase HCK 0.0029 0.1356 0.1356
Plasmodium falciparum protein kinase, putative 0.0029 0.1356 0.5
Brugia malayi hypothetical protein 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase csk 0.0029 0.1356 0.1356
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0029 0.1356 0.1356
Brugia malayi Guanylyl cyclase protein 23 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus multilocularis integrin linked protein kinase 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0029 0.1356 0.1752
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Echinococcus multilocularis tyrosine protein kinase csk 0.0029 0.1356 0.1356
Schistosoma mansoni protein kinase 0.0029 0.1356 0.1752
Loa Loa (eye worm) TK/DDR protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus ephrin type A receptor 4 A 0.0029 0.1356 0.1356
Plasmodium vivax protein kinase, putative 0.0029 0.1356 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0029 0.1356 0.1356
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0101 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.1356 0.1356
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Trypanosoma brucei protein kinase, putative 0.0029 0.1356 0.5
Echinococcus multilocularis tyrosine protein kinase 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Loa Loa (eye worm) RGC/RGC protein kinase 0.0029 0.1356 0.1387
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus multilocularis tyrosine protein kinase Blk 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Loa Loa (eye worm) RGC/RGC protein kinase 0.0029 0.1356 0.1387
Echinococcus multilocularis heat shock protein 70 0.0029 0.1356 0.1356
Leishmania major protein kinase, putative 0.0029 0.1356 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0029 0.1356 0.1387
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK protein kinase 0.0029 0.1356 0.1387
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus tyrosine protein kinase Lyn 0.0029 0.1356 0.1356
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0029 0.1356 0.1356
Schistosoma mansoni serine/threonine RGC 0.0029 0.1356 0.1752
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.1356 0.1752
Toxoplasma gondii protein kinase 0.0029 0.1356 0.5
Entamoeba histolytica protein kinase, putative 0.0032 0.1746 1
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Onchocerca volvulus 0.008 0.7409 1
Brugia malayi Raf kinase 0.0029 0.1356 0.1356
Brugia malayi hypothetical protein 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK protein kinase 0.0029 0.1356 0.1387
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus epidermal growth factor receptor 0.0029 0.1356 0.1356
Echinococcus multilocularis protein kinase 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus multilocularis protein tyrosine kinase 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Loa Loa (eye worm) TK/ALK protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine kinase 0.0029 0.1356 0.1356
Plasmodium falciparum protein kinase, putative 0.0029 0.1356 0.5
Echinococcus granulosus tyrosine kinase 0.0029 0.1356 0.1356
Schistosoma mansoni jun-related protein 0.0082 0.774 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0029 0.1356 0.5
Echinococcus multilocularis jun protein 0.0101 1 1
Echinococcus granulosus protein kinase 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine protein kinase shark 0.0029 0.1373 0.1373
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0029 0.1356 0.1356
Schistosoma mansoni protein kinase 0.0029 0.1356 0.1752
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus granulosus fibroblast growth factor receptor 4 0.0029 0.1356 0.1356
Brugia malayi SH2 domain containing protein 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK protein kinase 0.0029 0.1356 0.1387
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.1356 0.1356
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.1356 0.1752
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus granulosus activin receptor type 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine protein kinase csk 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine kinase 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Schistosoma mansoni protein kinase 0.0029 0.1356 0.1752
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus tyrosine protein kinase Src42A 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Brugia malayi C-terminal src kinase protein 1 0.0029 0.1356 0.1356
Echinococcus multilocularis raf serine:threonine protein kinase 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK protein kinase 0.0029 0.1356 0.1387
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0029 0.1356 0.1752
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0029 0.1356 0.1387
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0029 0.1356 0.1752
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus multilocularis FL cytokine receptor 0.0029 0.1356 0.1356
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.1356 0.1752
Echinococcus granulosus retinal guanylyl cyclase 2 0.0029 0.1356 0.1356
Echinococcus multilocularis insulin receptor 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Trypanosoma cruzi protein kinase, putative 0.0029 0.1356 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Echinococcus granulosus integrin linked protein kinase 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Giardia lamblia Kinase, NEK 0.0029 0.1373 1
Echinococcus multilocularis epidermal growth factor receptor 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/INSR protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0029 0.1356 0.1356
Schistosoma mansoni protein kinase 0.0029 0.1373 0.1775
Echinococcus multilocularis protein KINase family member (kin 25) 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0029 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Entamoeba histolytica protein kinase, putative 0.0029 0.1356 0.0000030691
Echinococcus granulosus kinase suppressor of Ras 1 0.0029 0.1356 0.1356
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.1356 0.1356
Schistosoma mansoni protein kinase 0.0029 0.1356 0.1752
Schistosoma mansoni protein kinase 0.0029 0.1356 0.1752
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Trichomonas vaginalis TKL family protein kinase 0.0029 0.1356 1
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0029 0.1356 0.1356
Trypanosoma brucei Pseudokinase, putative 0.0029 0.1356 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Schistosoma mansoni tyrosine kinase 0.0029 0.1373 0.1775
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase csk 0.0029 0.1356 0.1356
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0029 0.1356 0.1356
Echinococcus granulosus activated cdc42 kinase 1 0.0029 0.1356 0.1356
Brugia malayi bone morphogenetic protein type 1 receptor 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0029 0.1356 0.1356
Loa Loa (eye worm) SRC-1 0.0029 0.1356 0.1387
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine protein kinase Abl 0.0029 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Schistosoma mansoni protein kinase 0.0029 0.1356 0.1752
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0029 0.1356 0.1356
Echinococcus multilocularis transfer RNA-Thr 0.0029 0.1356 0.1356
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0029 0.1356 0.1356
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0029 0.1356 0.1356
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0029 0.1356 0.1387
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus multilocularis Ankyrin 0.0018 0.0018 0.0018
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0029 0.1356 0.1356
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0029 0.1356 0.1387
Trypanosoma brucei Flagellum attachment zone protein 20 0.0029 0.1356 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Brugia malayi hypothetical protein 0.008 0.7409 0.7409
Echinococcus granulosus c src tyrosine kinase 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase 0.0029 0.1356 0.1356
Brugia malayi protein-tyrosine kinase 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.8515 0.8515
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus granulosus tyrosine protein kinase csk 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Schistosoma mansoni ephrin receptor 0.0029 0.1356 0.1752
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0029 0.1356 0.1752
Loa Loa (eye worm) TK protein kinase 0.0029 0.1356 0.1387
Plasmodium falciparum tyrosine kinase-like protein 0.0029 0.1356 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Schistosoma mansoni hypothetical protein 0.0029 0.1356 0.1752
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0029 0.1356 0.5
Echinococcus granulosus tyrosine protein kinase pr2 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase Src64B 0.0029 0.1356 0.1356
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0018 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.1356 0.1752
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0029 0.1356 0.5
Loa Loa (eye worm) hypothetical protein 0.0099 0.9669 1
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Brugia malayi ephrin receptor 1 precursor 0.0029 0.1356 0.1356
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Plasmodium vivax tyrosine kinase-like protein, putative 0.0029 0.1356 0.5
Giardia lamblia Protein 21.1 0.0029 0.1356 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0029 0.1356 0.1356
Entamoeba histolytica ankyrin repeat protein 0.0029 0.1356 0.0000030691
Entamoeba histolytica protein kinase, putative 0.0029 0.1356 0.0000030691
Echinococcus granulosus protein tyrosine kinase 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase shark 0.0029 0.1373 0.1373
Brugia malayi Tyrosine-protein kinase PR2 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine protein kinase HCK 0.0029 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Echinococcus granulosus insulin receptor 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/RYK protein kinase 0.0029 0.1356 0.1387
Brugia malayi integrin-linked kinase 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus granulosus epidermal growth factor receptor 0.0029 0.1356 0.1356
Brugia malayi Receptor family ligand binding region containing protein 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase Srms 0.0029 0.1356 0.1356
Echinococcus multilocularis tyrosine kinase 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Echinococcus multilocularis tyrosine protein kinase csk 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK/ROR protein kinase 0.0029 0.1356 0.1387
Leishmania major protein kinase, putative 0.0029 0.1356 0.5
Echinococcus granulosus receptor type guanylyl cyclase 0.0029 0.1356 0.1356
Trichomonas vaginalis TKL family protein kinase 0.0029 0.1356 1
Toxoplasma gondii protein kinase domain-containing protein 0.0029 0.1356 0.5
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0029 0.1356 0.1356
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0029 0.1356 0.1387
Trypanosoma cruzi protein kinase, putative 0.0029 0.1356 0.5
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0029 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Echinococcus multilocularis tyrosine protein kinase pr2 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.1356 0.5
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0029 0.1356 0.1356
Leishmania major hypothetical protein, conserved 0.0029 0.1356 0.5
Loa Loa (eye worm) TK/Met protein kinase 0.0029 0.1356 0.1387
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0029 0.1356 0.1752
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.1356 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0029 0.1356 0.1387
Echinococcus multilocularis c src tyrosine kinase 0.0029 0.1356 0.1356
Echinococcus multilocularis ephrin type A receptor 4 A 0.0029 0.1356 0.1356
Echinococcus granulosus activated cdc42 kinase 1 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.8515 0.8515
Loa Loa (eye worm) TK/FER protein kinase 0.0029 0.1356 0.1387
Schistosoma mansoni protein kinase 0.0029 0.1356 0.1752
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0029 0.1356 0.1356
Echinococcus granulosus retinal guanylyl cyclase 2 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus multilocularis receptor type guanylyl cyclase 0.0029 0.1356 0.1356
Loa Loa (eye worm) TK protein kinase 0.0029 0.1356 0.1387
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0029 0.1356 0.1356
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356
Echinococcus granulosus natriuretic peptide receptor 1 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus multilocularis activin receptor type 0.0029 0.1356 0.1356
Schistosoma mansoni tyrosine protein kinase 0.0029 0.1356 0.1752
Loa Loa (eye worm) TK/ABL protein kinase 0.0029 0.1356 0.1387
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0029 0.1356 0.5
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.1356 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.1356 0.1356
Plasmodium falciparum protein kinase, putative 0.0029 0.1356 0.5
Schistosoma mansoni tyrosine kinase 0.0029 0.1356 0.1752
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0029 0.1356 0.1356
Echinococcus granulosus tyrosine protein kinase Blk 0.0029 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.0029 0.1356 0.1387
Plasmodium falciparum tyrosine kinase-like protein 0.0029 0.1356 0.5
Entamoeba histolytica hypothetical protein 0.0032 0.1746 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0101 1 1
Brugia malayi Protein kinase domain containing protein 0.0029 0.1356 0.1356

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of tyrosinase ChEMBL. 19359068
IC50 (binding) = 4200 nM Cellular Firefly Luciferase Assay (NFkB) BINDINGDB. No reference
IC50 (binding) = 11700 nM Cellular Firefly Luciferase Assay (AP-1) BINDINGDB. No reference
IC50 (functional) = 10.24 uM Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-stimulated nitric oxide production after 17 to 20 hrs by Griess assay ChEMBL. 19359068

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 19359068

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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