Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y1 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | neuropeptide Y receptor Y1 | 384 aa | 345 aa | 22.0 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0023 | 0.0085 |
Onchocerca volvulus | 0.0036 | 0.1058 | 0.3929 | |
Echinococcus granulosus | serotonin transporter | 0.0073 | 0.2693 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0073 | 0.2693 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | thyroglobulin type-1 repeat family protein | 0.0036 | 0.1058 | 0.1058 |
Onchocerca volvulus | 0.0036 | 0.1058 | 0.3929 | |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0237 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0073 | 0.2693 | 0.2693 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0023 | 0.0085 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.1429 | 0.1429 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.0036 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1167 | 0.1167 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.0036 | 0.1058 | 0.1058 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0073 | 0.2693 | 0.2693 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1611 | 0.598 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0125 | 0.5014 | 0.5014 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0237 | 1 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0073 | 0.2693 | 0.2693 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0023 | 0.0085 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0237 | 1 | 1 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.0036 | 0.1058 | 0.1058 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0237 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.1429 | 0.5305 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0.2693 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2693 | 0.2693 |
Onchocerca volvulus | 0.0073 | 0.2693 | 1 | |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0237 | 1 | 0.5 |
Onchocerca volvulus | 0.0036 | 0.1058 | 0.3929 | |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0237 | 1 | 0.5 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.0036 | 0.1058 | 0.1058 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0073 | 0.2693 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.1611 | 0.598 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2693 | 0.2693 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1058 | 0.1058 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0237 | 1 | 1 |
Loa Loa (eye worm) | thyroglobulin type-1 repeat family protein | 0.0036 | 0.1058 | 0.1058 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0237 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0073 | 0.2693 | 0.2693 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.1429 | 0.5305 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2693 | 0.2693 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.1429 | 0.1429 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0073 | 0.2693 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0023 | 0.0023 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0237 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0237 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0.1058 | 0.3929 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0023 | 0.0085 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0023 | 0.0023 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0023 | 0.0085 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0023 | 0.0085 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0125 | 0.5014 | 0.5014 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1058 | 0.1058 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 17 nM | Displacement of [3H]imipramine from human serotonin transporter expressed in CHO cell membrane by scintillation counting | ChEMBL. | 19596193 |
IC50 (binding) | = 9600 nM | Displacement of [35S]MK499 from human ERG potassium channel expressed in HEK293 cells | ChEMBL. | 19596193 |
Ki (binding) | = 29 nM | Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting | ChEMBL. | 19596193 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.