Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cathepsin D | Starlite/ChEMBL | References |
Homo sapiens | beta-site APP-cleaving enzyme 2 | Starlite/ChEMBL | References |
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | cathepsin D | 412 aa | 339 aa | 28.9 % |
Plasmodium falciparum | plasmepsin V | beta-site APP-cleaving enzyme 2 | 518 aa | 439 aa | 21.9 % |
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.