Detailed information for compound 1055575

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 302.413 | Formula: C21H22N2
  • H donors: 0 H acceptors: 0 LogP: 4.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C(CCn1ccc2c1cccc2)CCn1ccc2c1cccc2
  • InChi: 1S/C21H22N2/c1(6-14-22-16-12-18-8-2-4-10-20(18)22)7-15-23-17-13-19-9-3-5-11-21(19)23/h2-5,8-13,16-17H,1,6-7,14-15H2
  • InChiKey: YYJZJNRCWKBQFQ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus 0.0048 0.7307 0.7192
Plasmodium falciparum tyrosine kinase-like protein 0.0013 0.0409 0.5
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0013 0.0409 0.0409
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Brugia malayi cytokine inducible SH2-containing protein 5 0.0048 0.7307 0.7307
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0013 0.0409 0.0409
Echinococcus granulosus signal transduction protein lnk realted 0.0048 0.7307 0.7307
Plasmodium vivax protein kinase, putative 0.0013 0.0409 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0013 0.0409 0.0409
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0409 0.5
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0013 0.0409 0.0409
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0013 0.0409 0.5
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0048 0.7307 0.7307
Onchocerca volvulus 0.0061 1 1
Echinococcus multilocularis protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Brugia malayi hypothetical protein 0.0061 1 1
Schistosoma mansoni tensin-related 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/INSR protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0061 1 1
Entamoeba histolytica SH2 domain containing protein 0.0048 0.7307 0.7192
Schistosoma mansoni serine/threonine RGC 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine protein kinase 0.0013 0.0409 0.0409
Brugia malayi integrin-linked kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/FER protein kinase 0.0061 1 1
Echinococcus granulosus expressed conserved protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/FER protein kinase 0.0061 1 1
Brugia malayi SH2 domain containing protein 0.0048 0.7307 0.7307
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/EPH protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0061 1 1
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Echinococcus multilocularis insulin receptor 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/ABL protein kinase 0.0061 1 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0048 0.7307 0.7192
Loa Loa (eye worm) RGC/RGC protein kinase 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0013 0.0409 0.5
Brugia malayi Sex muscle abnormal protein 5 0.0048 0.7307 0.7307
Plasmodium vivax tyrosine kinase-like protein, putative 0.0013 0.0409 0.5
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) RGC/RGC protein kinase 0.0013 0.0409 0.0409
Giardia lamblia Kinase, NEK 0.0013 0.0409 0.5
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase 0.0013 0.0409 0.0409
Plasmodium falciparum protein kinase, putative 0.0013 0.0409 0.5
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0061 1 1
Leishmania major protein kinase, putative 0.0013 0.0409 0.5
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) STAT protein 0.0048 0.7307 0.7307
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0061 1 1
Trypanosoma cruzi protein kinase, putative 0.0013 0.0409 0.5
Loa Loa (eye worm) TK/ACK protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0061 1 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0409 0.0409
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Echinococcus granulosus integrin linked protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase csk 0.0013 0.0409 0.0409
Echinococcus multilocularis 0.0048 0.7307 0.7307
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0013 0.0409 0.0409
Brugia malayi Receptor family ligand binding region containing protein 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase csk 0.0013 0.0409 0.0409
Echinococcus multilocularis SH2 domain containing protein 7 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK protein kinase 0.0013 0.0409 0.0409
Brugia malayi Furin-like cysteine rich region family protein 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0013 0.0409 0.0409
Brugia malayi SRC-1 0.0061 1 1
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Echinococcus multilocularis N chimaerin 0.0048 0.7307 0.7307
Brugia malayi SH2 domain containing protein 0.0048 0.7307 0.7307
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0061 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 1 1
Brugia malayi Protein kinase domain containing protein 0.0061 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Echinococcus granulosus growth factor receptor bound protein 2 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/CSK protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0013 0.0409 0.0409
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0409 0.5
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase csk 0.0013 0.0409 0.0409
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Onchocerca volvulus 0.0048 0.7307 0.7192
Loa Loa (eye worm) SH2 domain-containing protein 0.0048 0.7307 0.7307
Echinococcus multilocularis tyrosine protein kinase csk 0.0013 0.0409 0.0409
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0048 0.7307 0.7307
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0013 0.0409 0.0409
Brugia malayi C-terminal src kinase protein 1 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus granulosus SH2 domain containing adapter protein F 0.0048 0.7307 0.7307
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0409 0.5
Schistosoma mansoni tyrosine kinase 0.0061 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/Met protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.5598 0.5598
Brugia malayi tRNA modification GTPase TrmE family protein 0.0048 0.7307 0.7307
Entamoeba histolytica protein kinase, putative 0.0048 0.7307 0.7192
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 1 1
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0048 0.7307 0.7307
Plasmodium vivax tyrosine kinase-like protein, putative 0.0013 0.0409 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.7307 0.7307
Echinococcus granulosus SH2 motif 0.0048 0.7307 0.7307
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Onchocerca volvulus 0.0061 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Giardia lamblia Kinase, NEK 0.0013 0.0409 0.5
Schistosoma mansoni tyrosine kinase 0.0061 1 1
Schistosoma mansoni hypothetical protein 0.0048 0.7307 0.7307
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0061 1 1
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Schistosoma mansoni vav2 0.0048 0.7307 0.7307
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase HCK 0.0013 0.0409 0.0409
Echinococcus granulosus c src tyrosine kinase 0.0061 1 1
Brugia malayi ephrin receptor 1 precursor 0.0013 0.0409 0.0409
Echinococcus granulosus activated cdc42 kinase 1 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis epidermal growth factor receptor 0.0013 0.0409 0.0409
Brugia malayi SH2 domain containing protein 0.0048 0.7307 0.7307
Echinococcus granulosus hypothetical protein 0.0048 0.7307 0.7307
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 1 1
Echinococcus multilocularis protein kinase 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis integrin linked protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0048 0.7307 0.7307
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0013 0.0409 0.0409
Onchocerca volvulus 0.0048 0.7307 0.7192
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0013 0.0409 0.0409
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.5598 0.5598
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0061 1 1
Brugia malayi Variant SH3 domain containing protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) RGC/RGC protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni nck2/grb4 0.0048 0.7307 0.7307
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0048 0.7307 0.7307
Echinococcus multilocularis raf serine:threonine protein kinase 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0061 1 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0048 0.7307 0.7307
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0048 0.7307 0.7307
Schistosoma mansoni tensin 0.0048 0.7307 0.7307
Echinococcus granulosus SH2 domain containing protein 7 0.0048 0.7307 0.7307
Loa Loa (eye worm) hypothetical protein 0.0034 0.4558 0.4558
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0048 0.7307 0.7307
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0048 0.7307 0.7307
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0013 0.0409 0.0409
Brugia malayi STAT protein, DNA binding domain containing protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0409 0.0409
Brugia malayi Tyrosine-protein kinase PR2 0.0013 0.0409 0.0409
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.5598 0.5598
Echinococcus multilocularis kinase suppressor of Ras 1 0.0013 0.0409 0.0409
Schistosoma mansoni protein tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0061 1 1
Echinococcus granulosus receptor type guanylyl cyclase 0.0013 0.0409 0.0409
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0409
Trypanosoma brucei Flagellum attachment zone protein 20 0.0013 0.0409 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase HCK 0.0013 0.0409 0.0409
Loa Loa (eye worm) SRC-1 0.0061 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 1 1
Brugia malayi protein-tyrosine kinase 0.0061 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0061 1 1
Echinococcus multilocularis FL cytokine receptor 0.0013 0.0409 0.0409
Onchocerca volvulus 0.0061 1 1
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0013 0.0409 0.0409
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0061 1 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0048 0.7307 0.7192
Echinococcus granulosus tensin 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/ROR protein kinase 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK protein kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK protein kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0061 1 1
Schistosoma mansoni tensin-related 0.0048 0.7307 0.7307
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0061 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.6322 0.6322
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0013 0.0409 0.0409
Giardia lamblia Kinase 0.0013 0.0409 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0061 1 1
Brugia malayi SH2 domain containing protein 0.0061 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 1 1
Echinococcus granulosus SH2 motif 0.0048 0.7307 0.7307
Trypanosoma cruzi protein kinase, putative 0.0013 0.0409 0.5
Echinococcus granulosus tyrosine kinase 0.0061 1 1
Echinococcus multilocularis activin receptor type 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Brugia malayi bone morphogenetic protein type 1 receptor 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Echinococcus granulosus epidermal growth factor receptor 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/FER protein kinase 0.0061 1 1
Plasmodium falciparum protein kinase, putative 0.0013 0.0409 0.5
Loa Loa (eye worm) TK protein kinase 0.0061 1 1
Echinococcus multilocularis tyrosine protein kinase 0.0013 0.0409 0.0409
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0013 0.0409 0.0409
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0013 0.0409 0.0409
Echinococcus multilocularis epidermal growth factor receptor 0.0013 0.0409 0.0409
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0013 0.0409 0.0409
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0013 0.0409 0.0409
Trypanosoma brucei Pseudokinase, putative 0.0013 0.0409 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Schistosoma mansoni adapter molecule crk 0.0048 0.7307 0.7307
Echinococcus multilocularis NCK adaptor protein 0.0048 0.7307 0.7307
Echinococcus multilocularis activated cdc42 kinase 1 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.6322 0.6322
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase Srms 0.0061 1 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0061 1 1
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0048 0.7307 0.7307
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0048 0.7307 0.7307
Brugia malayi Raf kinase 0.0013 0.0409 0.0409
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Brugia malayi Tensin 0.0048 0.7307 0.7307
Echinococcus multilocularis tyrosine protein kinase csk 0.0013 0.0409 0.0409
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/DDR protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0013 0.0409 0.0409
Onchocerca volvulus 0.0061 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 1 1
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase Src42A 0.0061 1 1
Schistosoma mansoni hypothetical protein 0.0048 0.7307 0.7307
Schistosoma mansoni suppressor of cytokine signaling 0.0048 0.7307 0.7307
Loa Loa (eye worm) RGC/RGC protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0013 0.0409 0.0409
Echinococcus granulosus activin receptor type 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0048 0.7307 0.7307
Echinococcus multilocularis tyrosine protein kinase Abl 0.0061 1 1
Echinococcus multilocularis SHC transforming protein 3 0.0048 0.7307 0.7307
Plasmodium falciparum protein kinase, putative 0.0013 0.0409 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase ABL1 0.0061 1 1
Schistosoma mansoni SH2A 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/FER protein kinase 0.0061 1 1
Onchocerca volvulus 0.0048 0.7307 0.7192
Echinococcus granulosus retinal guanylyl cyclase 2 0.0013 0.0409 0.0409
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis SH2 motif 0.0048 0.7307 0.7307
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Echinococcus multilocularis SH2 motif 0.0048 0.7307 0.7307
Plasmodium falciparum tyrosine kinase-like protein 0.0013 0.0409 0.5
Brugia malayi SH2 domain containing protein 0.0048 0.7307 0.7307
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis growth factor receptor bound protein 2 0.0048 0.7307 0.7307
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Brugia malayi Immunoglobulin I-set domain containing protein 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Echinococcus granulosus insulin receptor 0.0013 0.0409 0.0409
Echinococcus multilocularis SH2 motif 0.0048 0.7307 0.7307
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0048 0.7307 0.7192
Schistosoma mansoni tensin 0.0048 0.7307 0.7307
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0013 0.0409 0.0409
Echinococcus granulosus retinal guanylyl cyclase 2 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase Src64B 0.0061 1 1
Echinococcus granulosus suppressor of cytokine signaling 6 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/ALK protein kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tensin 0.0048 0.7307 0.7307
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Schistosoma mansoni signal transduction protein lnk-related 0.0048 0.7307 0.7307
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/FER protein kinase 0.0061 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.0048 0.7307 0.7307
Echinococcus granulosus protein tyrosine kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/FER protein kinase 0.0061 1 1
Echinococcus multilocularis c src tyrosine kinase 0.0061 1 1
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0013 0.0409 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0048 0.7307 0.7307
Brugia malayi Tyrosine-protein kinase abl-1 0.0061 1 1
Brugia malayi Protein kinase domain containing protein 0.0061 1 1
Brugia malayi SH2 domain containing protein 0.0048 0.7307 0.7307
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus granulosus raf serine:threonine protein kinase 0.0013 0.0409 0.0409
Brugia malayi hypothetical protein 0.0048 0.7307 0.7307
Echinococcus granulosus tyrosine protein kinase pr2 0.0013 0.0409 0.0409
Echinococcus granulosus activated cdc42 kinase 1 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis natriuretic peptide receptor 1 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase Lyn 0.0061 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) SH2 domain-containing protein 0.0048 0.7307 0.7307
Echinococcus granulosus tyrosine protein kinase csk 0.0013 0.0409 0.0409
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.5598 0.5598
Brugia malayi Variant SH3 domain containing protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0061 1 1
Brugia malayi hypothetical protein 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase shark 0.0061 1 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0048 0.7307 0.7307
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0048 0.7307 0.7307
Brugia malayi SH2 domain containing protein 0.0048 0.7307 0.7307
Echinococcus multilocularis receptor type guanylyl cyclase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/EGFR protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/FER protein kinase 0.0061 1 1
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Echinococcus granulosus protein kinase 0.0013 0.0409 0.0409
Echinococcus granulosus kinase suppressor of Ras 1 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Toxoplasma gondii protein kinase domain-containing protein 0.0013 0.0409 0.5
Echinococcus granulosus fibroblast growth factor receptor 4 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/FER protein kinase 0.0061 1 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0048 0.7307 0.7307
Echinococcus granulosus tyrosine protein kinase Blk 0.0061 1 1
Schistosoma mansoni tyrosine kinase 0.0061 1 1
Schistosoma mansoni hypothetical protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Onchocerca volvulus 0.0048 0.7307 0.7192
Echinococcus granulosus tyrosine protein kinase csk 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0061 1 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/FAK protein kinase 0.0013 0.0409 0.0409
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Echinococcus granulosus natriuretic peptide receptor 1 0.0013 0.0409 0.0409
Echinococcus granulosus retinal guanylyl cyclase 2 0.0013 0.0409 0.0409
Onchocerca volvulus 0.0061 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0048 0.7307 0.7307
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0048 0.7307 0.7307
Brugia malayi Protein kinase domain containing protein 0.0013 0.0409 0.0409
Echinococcus granulosus SHC transforming protein 3 0.0048 0.7307 0.7307
Echinococcus multilocularis transfer RNA-Thr 0.0013 0.0409 0.0409
Brugia malayi Variant SH3 domain containing protein 0.0048 0.7307 0.7307
Onchocerca volvulus 0.0048 0.7307 0.7192
Schistosoma mansoni GTPase activating protein 0.0048 0.7307 0.7307
Echinococcus multilocularis tyrosine kinase 0.0013 0.0409 0.0409
Schistosoma mansoni ephrin receptor 0.0013 0.0409 0.0409
Schistosoma mansoni shc transforming protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) serine/threonine protein kinase 0.0013 0.0409 0.0409
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.508 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.7307 0.7307
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 1 1
Schistosoma mansoni tensin 0.0048 0.7307 0.7307
Loa Loa (eye worm) SH2 domain-containing protein 0.0048 0.7307 0.7307
Loa Loa (eye worm) protein kinase domain-containing protein 0.0013 0.0409 0.0409
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0061 1 1
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Brugia malayi RhoGAP domain containing protein 0.0048 0.7307 0.7307
Trypanosoma brucei protein kinase, putative 0.0013 0.0409 0.5
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0048 0.7307 0.7307
Loa Loa (eye worm) TK/FER protein kinase 0.0061 1 1
Leishmania major protein kinase, putative 0.0013 0.0409 0.5
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0048 0.7307 0.7307
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK protein kinase 0.0013 0.0409 0.0409
Toxoplasma gondii STE kinase 0.0013 0.0409 0.5
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0013 0.0409 0.0409
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0013 0.0409 0.0409
Onchocerca volvulus 0.0061 1 1
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Brugia malayi hypothetical protein 0.0013 0.0409 0.0409
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0048 0.7307 0.7307
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.7307 0.7307
Echinococcus multilocularis protein tyrosine kinase 0.0013 0.0409 0.0409
Brugia malayi SH2 domain containing protein 0.0048 0.7307 0.7307
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase shark 0.0061 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.7307 0.7307
Leishmania major hypothetical protein, conserved 0.0013 0.0409 0.5
Schistosoma mansoni ephrin receptor 0.0013 0.0409 0.0409
Toxoplasma gondii protein kinase 0.0013 0.0409 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0061 1 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0013 0.0409 0.0409
Echinococcus multilocularis ephrin type A receptor 4 A 0.0013 0.0409 0.0409
Brugia malayi Guanylyl cyclase protein 23 0.0013 0.0409 0.0409
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis heat shock protein 70 0.0013 0.0409 0.0409
Echinococcus multilocularis tensin 0.0048 0.7307 0.7307
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0048 0.7307 0.7307
Echinococcus granulosus ephrin type A receptor 4 A 0.0013 0.0409 0.0409
Brugia malayi SH2 domain containing protein 0.0061 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0013 0.0409 0.5
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0061 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.508 1
Brugia malayi Protein kinase domain containing protein 0.0061 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0013 0.0409 0.0409
Giardia lamblia Protein 21.1 0.0013 0.0409 0.5
Loa Loa (eye worm) TK/RYK protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine kinase 0.0061 1 1
Schistosoma mansoni protein kinase 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Echinococcus granulosus tyrosine protein kinase Srms 0.0061 1 1
Schistosoma mansoni suppressor of cytokine signaling 0.0048 0.7307 0.7307
Loa Loa (eye worm) hypothetical protein 0.0013 0.0409 0.0409
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK protein kinase 0.0013 0.0409 0.0409
Echinococcus granulosus N chimaerin 0.0048 0.7307 0.7307
Schistosoma mansoni tyrosine kinase 0.0061 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.7307 0.7307
Echinococcus granulosus tyrosine kinase 0.0061 1 1
Echinococcus granulosus NCK adaptor protein 0.0048 0.7307 0.7307
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0013 0.0409 0.0409
Echinococcus multilocularis protein KINase family member (kin 25) 0.0013 0.0409 0.0409
Schistosoma mansoni tyrosine kinase 0.0013 0.0409 0.0409
Loa Loa (eye worm) TK/FER protein kinase 0.0013 0.0409 0.0409
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0061 1 1
Brugia malayi Variant SH3 domain containing protein 0.0048 0.7307 0.7307

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 52 uM Inhibition of human CDK4/ Cyclin D1 catalytic subunit expressed in Sf9 insect cells assessed as GST-RB152 fusion protein phosphorylation-associated depletion in ATP level by luminescence assay ChEMBL. 19632122
IC50 (binding) = 950 uM Inhibition of human CDK2/ Cyclin A catalytic subunit expressed in Sf9 insect cells assessed as histone H1 phosphorylation-associated depletion in ATP level by luminescence assay ChEMBL. 19632122

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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