Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 5 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 502 aa | 458 aa | 24.4 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | 0.00248392 | 0 | 0.5 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.138682 | 1 | 0.5 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.138682 | 1 | 0.5 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.138682 | 1 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.00248392 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.138682 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.138682 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.00248392 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.00248392 | 0 | 0.5 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.138682 | 1 | 0.5 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.138682 | 1 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0500044 | 0.348907 | 0.348907 |
Brugia malayi | Bm-MIF-1, identical | 0.138682 | 1 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.138682 | 1 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.138682 | 1 | 0.5 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.138682 | 1 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0500044 | 0.348907 | 0.348907 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0275 uM | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. | ChEMBL. | No reference |
IC50 (functional) | = 0.028 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen TcVI extracellular trypomastigotes forms transfected with beta-galactosidase gene infected in rat L6 cells assessed as inhibition of parasite growth after 4 days | ChEMBL. | 23462713 |
IC50 (ADMET) | = 1 uM | Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylation | ChEMBL. | 23462713 |
IC90 (functional) | = 0.0825 uM | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 23462713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.