Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | transporter, cation channel family protein | 0.0055 | 0.0516 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0433 | 0.6469 |
Schistosoma mansoni | voltage-gated cation channel | 0.0158 | 0.1799 | 0.2747 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0064 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0281 | 0.0596 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0281 | 0.0819 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0281 | 0.0596 |
Echinococcus multilocularis | geminin | 0.0539 | 0.6547 | 0.6525 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0281 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0433 | 0.1012 |
Onchocerca volvulus | 0.0036 | 0.0281 | 0.5 | |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0158 | 0.1799 | 0.1746 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0158 | 0.1799 | 0.1746 |
Echinococcus multilocularis | zinc finger transcription factor gli2 | 0.0311 | 0.3708 | 0.3668 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0281 | 0.4809 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0055 | 0.0516 | 0.1239 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0281 | 0.0819 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0516 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1799 | 0.4759 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0281 | 0.0596 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0281 | 0.043 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0281 | 0.4809 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0281 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0064 | 0.0098 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0064 | 0.0098 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0158 | 0.1799 | 0.1746 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0158 | 0.1799 | 0.2675 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0281 | 0.0596 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0281 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0231 | 0.2715 | 1 |
Loa Loa (eye worm) | calcium channel | 0.0158 | 0.1799 | 0.4759 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0158 | 0.1799 | 0.1746 |
Schistosoma mansoni | hypothetical protein | 0.0539 | 0.6547 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0281 | 0.0819 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0281 | 0.0596 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0281 | 0.0819 |
Schistosoma mansoni | hypothetical protein | 0.0539 | 0.6547 | 1 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0055 | 0.0516 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0281 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0281 | 0.0819 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0311 | 0.3708 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0158 | 0.1799 | 0.2675 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0064 | 0.0098 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0281 | 0.0819 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0433 | 0.1012 |
Loa Loa (eye worm) | zinc finger protein | 0.0311 | 0.3708 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0281 | 0.0596 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0158 | 0.1799 | 0.2675 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0281 | 0.5 |
Echinococcus granulosus | geminin | 0.0539 | 0.6547 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0281 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0281 | 0.0819 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0281 | 0.0596 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0158 | 0.1799 | 0.1746 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0281 | 0.4809 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0281 | 0.0819 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0281 | 0.0596 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0281 | 1 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0055 | 0.0516 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0281 | 0.0219 |
Onchocerca volvulus | 0.0036 | 0.0281 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0281 | 0.0596 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0281 | 0.0335 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0281 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0281 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0281 | 0.0596 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0281 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0281 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0281 | 1 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0158 | 0.1799 | 0.1746 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0158 | 0.1799 | 0.4759 |
Echinococcus granulosus | zinc finger transcription factor gli2 | 0.0311 | 0.3708 | 0.5621 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0281 | 0.0819 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0281 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0281 | 0.043 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0281 | 1 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0055 | 0.0516 | 0.0696 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0158 | 0.1799 | 0.2675 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0281 | 0.0819 |
Onchocerca volvulus | 0.0036 | 0.0281 | 0.5 | |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0281 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0281 | 0.0596 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0281 | 0.0596 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0158 | 0.1799 | 0.2747 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0158 | 0.1799 | 0.2747 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0064 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 6.2 % | Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of iNOS protein expression at 10 uM after 16 hrs by immunoblot analysis relative to control | ChEMBL. | 19433363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.