TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.418 | Formula: C20H16N2O2S
H donors: 2 H acceptors: 1 LogP: 4.81 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: C[C@@H]1CNc2c(C(=O)N1)sc1c2c2cc(oc2cc1)c1ccccc1
InChi: 1S/C20H16N2O2S/c1-11-10-21-18-17-13-9-15(12-5-3-2-4-6-12)24-14(13)7-8-16(17)25-19(18)20(23)22-11/h2-9,11,21H,10H2,1H3,(H,22,23)/t11-/m1/s1
InChiKey: HJSVRZBFKFCGAZ-LLVKDONJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase-activated protein kinase 2	Starlite/ChEMBL	References
Homo sapiens	cyclin-dependent kinase 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	Cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02090 cyclin-dependent kinase 5, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_131483	All targets in OG5_131483
Leishmania braziliensis	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Trypanosoma brucei	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium hominis	cdc2-like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium berghei	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Theileria parva	cell division control protein 2 related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cell division protein kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Babesia bovis	cell division control protein 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	map kinase activated protein kinase protein 2	Get druggable targets OG5_131483	All targets in OG5_131483
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	protein kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative	Get druggable targets OG5_131483	All targets in OG5_131483
Trypanosoma brucei gambiense	cell division related protein kinase 2, putative,CDC2-related protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02087 cyclin-dependent kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Neospora caninum	CMGC kinase, CDK family TgPK2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	Cdc2-like CDK2/CDC28 like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	protein kinase Crk2	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	MAP kinase activated protein kinase 2	Get druggable targets OG5_131483	All targets in OG5_131483
Leishmania major	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 3	305 aa	303 aa	32.0 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase-activated protein kinase 2	370 aa	303 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0054	0.0054
Echinococcus multilocularis	G protein coupled receptor 139	0.0021	0.0054	0.0054
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0218	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0021	0.0054	0.0054
Brugia malayi	Serotonin receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0054	0.0054
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0021	0.0054	0.0054
Echinococcus multilocularis	orexin receptor type 2	0.0021	0.0054	0.0054
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	cyclin dependent kinase 5	0.0053	0.1633	0.1633
Loa Loa (eye worm)	melatonin receptor type 1A	0.0021	0.0054	0.0054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0021	0.0054	0.0054
Echinococcus granulosus	7TM GPCR rhodopsin	0.0021	0.0054	0.0054
Echinococcus multilocularis	neuropeptide s receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0021	0.0054	0.0054
Brugia malayi	AKH receptor	0.0021	0.0054	0.0054
Brugia malayi	putative neuropeptide receptor	0.0021	0.0054	0.0054
Brugia malayi	larval opioid receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	growth hormone secretagogue receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	sex peptide receptor	0.0021	0.0054	0.0054
Plasmodium vivax	protein kinase Crk2	0.0053	0.1633	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0054	0.0054
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0054
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0021	0.0054	1
Onchocerca volvulus		0.0021	0.0054	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0053	0.1633	0.1633
Echinococcus granulosus	g-protein coupled receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.1633	0.1633
Brugia malayi	Dopamine receptor protein 2	0.0021	0.0054	0.0054
Schistosoma mansoni	neuropeptide f receptor 76f	0.0021	0.0054	0.0054
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0053	0.1633	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0054	0.0054
Giardia lamblia	Kinase, CMGC CDK	0.0053	0.1633	0.5
Brugia malayi	G-protein coupled receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	serotonin receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	allatostatin A receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0054	0.0054
Echinococcus multilocularis	cyclin dependent kinase 1	0.0053	0.1633	0.1633
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0054	0.0054
Plasmodium falciparum	protein kinase 5	0.0053	0.1633	0.5
Echinococcus granulosus	somatostatin receptor	0.0021	0.0054	0.0054
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0054
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.1633	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0054	0.0054
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0021	0.0054	0.0054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Brugia malayi	Dopamine receptor protein 1	0.0021	0.0054	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0054	0.0054
Echinococcus granulosus	neuropeptide receptor A26	0.0021	0.0054	0.0054
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	opsin-like receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	amine GPCR	0.0021	0.0054	0.0054
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0054	0.0054
Echinococcus multilocularis	neuropeptide receptor A26	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0218	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	g-protein coupled receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	cyclin dependent kinase 1	0.0053	0.1633	0.1633
Trypanosoma cruzi	cdc2-related kinase 3	0.0053	0.1633	0.5
Echinococcus granulosus	fmrfamide receptor	0.0021	0.0054	0.0054
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0021	0.0054	0.0054
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0021	0.0054	0.0054
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0021	0.0054	0.0054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Schistosoma mansoni	amine GPCR	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Echinococcus granulosus	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	serotonin receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0021	0.0054	0.0054
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1577	0.1577
Onchocerca volvulus		0.0021	0.0054	1
Onchocerca volvulus		0.0021	0.0054	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Brugia malayi	putative neuropeptide receptor NPR1	0.0021	0.0054	0.0054
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0054	0.0054
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	sex peptide receptor	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	opsin-like receptor	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0054	0.0054
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Echinococcus granulosus	cyclin dependent kinase 1	0.0053	0.1633	0.1633
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	myosin xvIII	0.0021	0.0054	0.0054
Echinococcus granulosus	cyclin dependent kinase	0.0053	0.1633	0.1633
Brugia malayi	ORL1-like opioid receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Entamoeba histolytica	cell division protein kinase 2, putative	0.0053	0.1633	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Giardia lamblia	Kinase, CMGC CDK	0.0053	0.1633	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0021	0.0054	0.0054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0054	0.0054
Brugia malayi	sulfakinin receptor protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	histamine h1 receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0054	0.0054
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0054	0.0054
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	amine GPCR	0.0021	0.0054	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0054	0.0054
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0054	0.0054
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0053	0.1633	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	G protein coupled receptor 139	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Brugia malayi	neuropeptide F receptor	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0054	0.0054
Trypanosoma cruzi	cdc2-related kinase 1	0.0053	0.1633	0.5
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	cyclin dependent kinase	0.0053	0.1633	0.1633
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0021	0.0054	0.0054
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	amine GPCR	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0021	0.0054	1
Brugia malayi	Dopamine receptor	0.0021	0.0054	0.0054
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0021	0.0054	0.0054
Brugia malayi	cell division control protein 2 homolog	0.0053	0.1633	0.1633
Trypanosoma brucei	cdc2-related kinase 1	0.0053	0.1633	0.5
Brugia malayi	RE15519p	0.0021	0.0054	0.0054
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Entamoeba histolytica	cell division protein kinase 2, putative	0.0053	0.1633	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0021	0.0054	0.0054
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0054	0.0054
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.1633	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.1633	0.5
Schistosoma mansoni	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus granulosus	orexin receptor type 2	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0053	0.1633	0.1633
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0054	0.0054
Brugia malayi	neuropeptide F receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Echinococcus granulosus	serotonin receptor	0.0021	0.0054	0.0054
Brugia malayi	G protein-coupled receptor F59B2.13	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0053	0.1633	0.1633
Brugia malayi	G protein-coupled receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0053	0.1633	0.1633
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Brugia malayi	G-protein coupled receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0218	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0021	0.0054	0.0054
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	TYRA-2 protein	0.0021	0.0054	0.0054
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0021	0.0054	0.0054
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0054	0.0054
Trypanosoma cruzi	cdc2-related kinase 3	0.0053	0.1633	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0021	0.0054	0.0054
Trypanosoma cruzi	cdc2-related kinase 1	0.0053	0.1633	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	adenoreceptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.1633	0.1633
Brugia malayi	Melatonin receptor type 1A	0.0021	0.0054	0.0054
Brugia malayi	GnHR receptor homolog	0.0021	0.0054	0.0054
Schistosoma mansoni	opsin-like receptor	0.0021	0.0054	0.0054
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0053	0.1633	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0054	0.0054
Onchocerca volvulus		0.0021	0.0054	1
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0021	0.0054	0.0054
Brugia malayi	follicle stimulating hormone receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	7tm_1 domain containing protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0021	0.0054	0.0054
Brugia malayi	Serotonin receptor	0.0021	0.0054	0.0054
Echinococcus multilocularis	somatostatin receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	cyclin dependent kinase 5	0.0053	0.1633	0.1633
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0054	0.0054
Trypanosoma brucei	cdc2-related kinase 3	0.0053	0.1633	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0054	0.0054
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0054	0.0054
Echinococcus granulosus	allatostatin A receptor	0.0021	0.0054	0.0054
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0054
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Brugia malayi	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0021	0.0054	0.0054
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0054	0.0054
Schistosoma mansoni	serine/threonine protein kinase	0.0218	1	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0021	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0054	0.0054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0054	0.0054
Schistosoma mansoni	amine GPCR	0.0021	0.0054	0.0054
Brugia malayi	Protein kinase domain containing protein	0.0053	0.1633	0.1633

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.15 uM	Inhibition of MK2	ChEMBL.	19616942
IC50 (binding)	= 0.25 uM	Inhibition of CDK2	ChEMBL.	19616942
IC50 (binding)	= 6.8 uM	Inhibition of MK2 in human U937 cells assessed as blockade of LPS-stimulated TNFalpha production	ChEMBL.	19616942

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL562194

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1059151