Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glycosyl hydrolases family 2, sugar binding domain containing protein | 0.0061 | 0.0492 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0835 | 0.191 |
Loa Loa (eye worm) | carboxylesterase | 0.0069 | 0.0835 | 0.191 |
Brugia malayi | Muscleblind-like protein | 0.0149 | 0.437 | 1 |
Entamoeba histolytica | beta-galactosidase, putative | 0.0117 | 0.2967 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.0835 | 0.191 |
Loa Loa (eye worm) | beta-glucuronidase | 0.0056 | 0.0286 | 0.0655 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0173 | 0.5442 | 0.5308 |
Echinococcus granulosus | muscleblind protein | 0.0149 | 0.437 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.437 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0149 | 0.437 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.505 | 1 |
Brugia malayi | manba-prov protein | 0.0056 | 0.0286 | 0.0655 |
Brugia malayi | Beta-glucuronidase precursor | 0.0056 | 0.0286 | 0.0655 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0835 | 0.191 |
Trichomonas vaginalis | beta-galactosidase, putative | 0.0173 | 0.5442 | 0.5308 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.0835 | 0.1151 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0069 | 0.0835 | 0.191 |
Loa Loa (eye worm) | glycosyl hydrolase family 2 | 0.0061 | 0.0492 | 0.1127 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.437 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.0835 | 0.191 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0149 | 0.437 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.