Detailed view for Bm1_45340

Basic information

TDR Targets ID: 233870
Brugia malayi, manba-prov protein
Source Database / ID:  GenBank

pI: 8.5067 | Length (AA): 900 | MW (Da): 104903 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02836   Glycosyl hydrolases family 2, TIM barrel domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0043169   cation binding  
GO:0003824   catalytic activity  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

Other glycan degradation (KEGG)
Lysosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 897 2je8 (A) 28 864 26.00 0 1 1.24787 0.05
32 894 4cvu (A) 38 938 25.00 0 1 1.20689 -0.09
32 727 5n6u (A) 10 654 34.00 0 1 1.06283 0.23
343 582 2cks (A) 139 387 13.00 0 0.52 0.299667 -0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129300)

Species Accession Gene Product
Arabidopsis thaliana AT1G09010   mannosylglycoprotein endo-beta-mannosidase
Brugia malayi Bm1_45340   manba-prov protein
Candida albicans CaO19.2838   similar to bacterial beta-mannosidase precursor
Candida albicans CaO19.10356   similar to bacterial beta-mannosidase precursor
Caenorhabditis elegans CELE_C33G3.4   Protein C33G3.4
Dictyostelium discoideum DDB_G0275917   hypothetical protein
Drosophila melanogaster Dmel_CG12582   CG12582 gene product from transcript CG12582-RG
Echinococcus granulosus EgrG_000789900   beta mannosidase
Echinococcus multilocularis EmuJ_000789900   beta mannosidase
Homo sapiens ENSG00000109323   mannosidase, beta A, lysosomal
Loa Loa (eye worm) LOAG_00317   manba-prov protein
Mus musculus ENSMUSG00000028164   mannosidase, beta A, lysosomal
Oryza sativa 4338683   Os05g0391500
Schistosoma japonicum Sjp_0009600   ko:K01192 beta-mannosidase [EC3.2.1.25], putative
Schistosoma mansoni Smp_137150   beta-mannosidase
Schmidtea mediterranea mk4.006794.00   Probable beta-mannosidase
Schmidtea mediterranea mk4.006794.01   Probable beta-mannosidase
Schmidtea mediterranea mk4.006794.02   Probable beta-mannosidase
Trichomonas vaginalis TVAG_483760   beta-mannosidase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Beta-mannosidase Compounds References
Homo sapiens mannosidase, beta A, lysosomal Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0077 0.2715 0.2858
0.0168 0.489 0.5566
0.0246 0.6821 0.8674
0.0285 0.5711 0.7113
0.0468 0.3211 0.336
0.0174 0.2925 0.2851
0.0422 0.2731 0.2731
0.0301 0.89 0.89
0.0331 0.961 0.961
0.0948 0.2717 0.3369
0.0312 0.3205 1
0.0312 0.2668 0.2584
0.1151 0.3227 0.3384
0.0577 0.3102 0.3161
0.0757 0.317 0.3298
0.0275 0.96 0.96
0.0158 0.3133 0.3274
0.0683 0.3229 0.3379
0.0274 0.973 0.973
0.1151 0.2769 0.3364
0.0171 0.2759 0.2903
0.049 0.3232 0.3382
0.0266 0.3639 0.44
0.0318 0.3129 0.3233
0.1112 0.3226 0.3384
0.0503 0.3234 0.3375
0.1139 0.3221 0.3378
0.0284 0.3286 0.7486
0.0578 0.3235 0.3379
0.0308 0.3197 1
0.122 0.3227 0.3385
0.0416 0.3164 0.332
0.0331 0.2978 0.2969
0.0586 0.3227 0.3382
0.0275 0.9609 0.9609
0.0305 0.3083 0.3082
0.1151 0.2769 0.3364
0.1096 0.3226 0.3383
0.0882 0.3222 0.338
0.0081 0.3177 0.3292
0.0482 0.3224 0.3312
0.0422 0.2731 0.2731
0.123 0.3224 0.338
0.0496 0.3216 0.3373
0.0422 0.2731 0.2731
0.0404 0.3195 0.3351
0.0396 0.3006 0.3157
0.0331 0.9597 0.9597
0.028 0.9786 0.9786
0.0901052 0.388478 0.470017
0.0252 0.2564 0.3285
0.0248 0.3091 0.3245
0.0405 0.3043 0.318
0.0286 0.4101 0.5179
0.112 0.3226 0.3383
0.0331 0.9597 0.9597
0.0416 0.253 0.3371
0.1047 0.3225 0.3382
0.0166 0.3097 0.3251
0.0286 0.295 0.3737
0.0081 0.3177 0.3292
0.0079 0.2824 0.2824
0.0717 0.2733 0.3363
0.0268585 0.293798 0.293409
0.1231 0.3222 0.3379
0.122 0.3227 0.3384
0.0274 0.973 0.973
0.0168 0.2664 0.2664
0.1065 0.3226 0.3383
0.0253 0.3017 0.3329
0.1105 0.3227 0.3384
0.0161 0.2963 0.3113
0.0284 0.3286 0.7486
0.0683 0.3229 0.3379
0.112 0.3226 0.3383
0.1141 0.3227 0.3384
0.114 0.3226 0.3383
0.019 0.2632 0.5966
0.1149 0.3232 0.3389
0.0129 0.3467 1
0.0343 0.2598 0.2099
0.0322 0.2622 0.2689
0.0948 0.2717 0.3369
0.12 0.3227 0.3385
0.114 0.3226 0.3383
0.0721 0.3217 0.3374
0.0265 0.2768 0.3903
0.0416 0.3164 0.332
0.0262 0.3073 0
0.0637 0.3086 0.3133
0.0292 0.4843 0.5605
0.0405 0.3043 0.318
0.0158 0.2976 0.3118
0.0422 0.2731 0.2731
0.0265 0.2768 0.3903
0.123 0.3224 0.338
0.0248 0.3091 0.3245
0.0742 0.3108 0.3172
0.0793 0.3121 0.3247
0.0077 0.2715 0.2858
0.0669 0.3207 0.3364
0.0948 0.2717 0.3369
0.024 0.2853 0.2846
0.0304 0.3072 1
0.024 0.2796 0.3175
0.0717 0.2733 0.3363
0.1067 0.3226 0.3383

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_45340 (Brugia malayi), manba-prov protein
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